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The addition of nanomolar concentration of TRAF2 in GUVs also seems to exert a mechanical action.
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 (显示 CRTC2 ELISA试剂盒) signalling
destabilization of TRAF2 by miR-17 reduced the ability of TRAF2 to associate with cIAP2 (显示 BIRC3 ELISA试剂盒), resulting in the downregulation of TNF-alpha (显示 TNF ELISA试剂盒)-induced NF-kappaBp65, c-Jun (显示 JUN ELISA试剂盒), and STAT3 (显示 STAT3 ELISA试剂盒) nuclear translocation and the production of IL-6 (显示 IL6 ELISA试剂盒), IL-8 (显示 IL8 ELISA试剂盒), MMP-1 (显示 MMP1 ELISA试剂盒), and MMP-13 (显示 MMP13 ELISA试剂盒) in human rheumatoid arthritis synovial fibroblasts.
HOXA1 (显示 HOXA1 ELISA试剂盒)-mediated activation of NF-kappaB (显示 NFKB1 ELISA试剂盒) is non-transcriptional and the RBCK1 (显示 RBCK1 ELISA试剂盒) and TRAF2 influences on NF-kappaB (显示 NFKB1 ELISA试剂盒) are epistatic to HOXA1 (显示 HOXA1 ELISA试剂盒)
RIPK1 (显示 RIPK1 ELISA试剂盒) collaborates with TRAF2 to inhibit murine and human hepatocarcinogenesis.
Data suggest that TRAF2 (TNF receptor-associated factor 2) negatively regulates (1) TNFR1- (tumor necrosis factor binding protein 1 (显示 TNFRSF1A ELISA试剂盒))-induced apoptosis, (2) TNFR2 (显示 TNFRSF1B ELISA试剂盒)- (tumor necrosis factor (显示 TNF ELISA试剂盒) receptor type 2)-induced non-canonical NFkappaB (显示 NFKB1 ELISA试剂盒) signaling, and (3) TNF- (tumor necrosis factor (显示 TNF ELISA试剂盒))-induced necroptosis. [REVIEW]
Study presents the characterization of the peptide binding preferences of TRAFs 2, 3, and 5 using deep mutational scanning. The three TRAF (显示 TRAF1 ELISA试剂盒) proteins demonstrated different preferences for binding to members of the CD40 (显示 CD40 ELISA试剂盒) library, and three peptides from that library individually showed striking differences in affinity for the three TRAFs.
The data demonstrate a novel and unexpected function of BIG1 (显示 CNTN3 ELISA试剂盒) that regulates TNFR1 (显示 TNFRSF1A ELISA试剂盒) signaling by targeting TRAF2.
TRAF2 expression was increased in gastric cancer patients as a result of DNA hypomethylation.
Data show that when death receptor 5 (DR5 (显示 TNFRSF10B ELISA试剂盒)) is suppressed, caspase-8 (显示 CASP8 ELISA试剂盒) may recruit and stabilize TNF receptor-associated factor 2 (TRAF2) to form a metastasis and invasion signaling complex, resulting in activation of ERK (显示 EPHB2 ELISA试剂盒) signaling.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒)-regulated apoptosis and the p53 (显示 TP53 ELISA试剂盒)/PCNA (显示 PCNA ELISA试剂盒)- and ATM (显示 ATM ELISA试剂盒)/ATR (显示 ATR ELISA试剂盒)-Chk1 (显示 CHEK1 ELISA试剂盒)/2-controlled DNA-damage response pathways.
Traf2 mediates the pro-survival pathway in the heart by suppressing necroptotic signaling.
Targeting TRAF2 may be useful as a therapeutic approach for immunosuppression-free islet allograft survival that avoids the thromboembolic complications associated with the use of anti-CD40L (显示 CD40LG ELISA试剂盒) antibodies.
Celastrol promotes Nur77 (显示 NR4A1 ELISA试剂盒) migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2. Ubiquitinated Nur77 (显示 NR4A1 ELISA试剂盒) then interacts with p62/SQSTM1 (显示 SQSTM1 ELISA试剂盒), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
this study shows that TRAF2 and TRAF5 (显示 TRAF5 ELISA试剂盒) work as important regulators of the IL-6R signaling needed for Th17 development
Keratinocyte-specific deletion of Traf2, but not Sphk1 (显示 SPHK1 ELISA试剂盒) deficiency, disrupted TNF (显示 TNF ELISA试剂盒) mediated NF-kappaB (显示 NFKB1 ELISA试剂盒) and MAP kinase (显示 MAPK1 ELISA试剂盒) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
TRAF2 functions as a key activator of MST1 (显示 MST1 ELISA试剂盒) in oxidative stress-induced (显示 SQSTM1 ELISA试剂盒) intracellular signaling processes.
Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages.
NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1 (显示 TRAF1 ELISA试剂盒)), TNF receptor-associated factor 2 (TRAF2), cellular inhibitor of apoptosis (cIAP2 (显示 BIRC3 ELISA试剂盒)), and Ferritin heavy chain (FTH1 (显示 FTH1 ELISA试剂盒)) were increased following Losartan treatment
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
, conjugal transfer protein TraF
, E3 ubiquitin-protein ligase TRAF2
, tumor necrosis factor type 2 receptor associated protein 3
, tumor necrosis factor type 2 receptor-associated protein 3
, TRAF family member-associated NFKB activator
, TNF receptor-associated factor 2