TNFRSF1A 蛋白 (TNFRSF1A)产品概述

Full name:
Tumor Necrosis Factor Receptor Superfamily, Member 1A 蛋白 (TNFRSF1A)
在www.antibodies-online.cn可供69 Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) 蛋白的18不同的供货商。 再加上,我们可以发TNFRSF1A 抗体 (451)TNFRSF1A 试剂盒 (59)和数多这个蛋白质的别的产品。 总共604 TNFRSF1A产品已列进来了。
别名:
CD120a, FPF, MS5, p55, p55-R, p60, TBP1, TNF-alphaR1, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNFalpha-R1, TNFAR, Tnfr-2, Tnfr1, TNFR1-d2, TNFR55, TNFR60, TNFR I, TNFRI, TNFRp55, TNFRSF1A, wu:fj65b10, xtnfr1, zgc:85914
列出全部蛋白 基因 基因ID UniProt
TNFRSF1A 7132 P19438
TNFRSF1A 21937 P25118
TNFRSF1A 25625 P22934

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引用最多的TNFRSF1A 蛋白

  1. Human TNFRSF1A Protein expressed in Escherichia coli (E. coli) - ABIN1047844 : Gray, Barrett, Chantry, Turner, Feldmann: Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 5 references for 1047844

  2. Human TNFRSF1A Protein expressed in Human Cells - ABIN2003515 : Banner, DArcy, Janes, Gentz, Schoenfeld, Broger, Loetscher, Lesslauer: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. in Cell 1993 (PubMed)
    Show all 5 references for 2003515

  3. Rat (Rattus) TNFRSF1A Protein expressed in Human Cells - ABIN2009259 : Chan, Chun, Zheng, Siegel, Bui, Lenardo: A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. in Science (New York, N.Y.) 2000 (PubMed)
    Show all 5 references for 2009259

  4. Mouse (Murine) TNFRSF1A Protein expressed in Human Cells - ABIN2007897 : Lewis, Tartaglia, Lee, Bennett, Rice, Wong, Chen, Goeddel: Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 5 references for 2007897

  5. Human TNFRSF1A Protein expressed in HEK-293 Cells - ABIN2181839 : Jiang, Woronicz, Liu, Goeddel: Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 references for 2181839

  6. Human TNFRSF1A Protein expressed in Escherichia coli (E. coli) - ABIN1098686 : Dunbar, Song, Guo, Wu, Donner: Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Show all 2 references for 1098686

更多TNFRSF1A互动伙伴

Human Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. Since mumps virus SH coimmunoprecipitated with tumor necrosis factor receptor 1 (TNFR1), RIP1 (显示 UQCRFS1 蛋白), and IRAK1 (显示 IRAK1 蛋白), we hypothesize that SH exerts its NF-kappaB (显示 NFKB1 蛋白) activation inhibitory function by interacting with TNFR1, interleukin-1 receptor type 1 (IL-1R1), and TLR3 (显示 TLR3 蛋白) complexes in the plasma membrane of infected cells.

  2. a specific link between the penetrance of the TNFRSF1A mutation and the observed T cell phenotype, is reported.

  3. Collectively, this study provides more insights into RELT (显示 RELT 蛋白) expression, RELT (显示 RELT 蛋白) family member function, and the mechanism of RELT (显示 RELT 蛋白)-induced death.

  4. Burkholderia cenocepacia BcaA binds to tumor necrosis factor receptor 1.

  5. In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression

  6. TNFRSF1A variants were identified in 10 tumor necrosis factor (显示 TNF 蛋白) receptor-associated periodic syndrome patients from 10 independent families. The T61I variant was found in patients, while the V136M and S321I variants were found in 1 patient each. All the patients were heterozygous for the variants. Among the healthy controls, 7 of 363 individuals were heterozygous for the T61I variant.

  7. Voxel-based morphometry was used to analyse the associations between TNFRSF1A (rs4149576 and rs4149577) and grey matter structure. Highly significant genotypic associations with striatal volume but not the hippocampus were seen. Specifically, for rs4149576, G homozygotes were associated with reduced caudate nucleus volumes relative to A homozygotes and heterozygotes. Reduced caudate volumes were observed in C homozygotes

  8. Circulating TNFR1 and 2 were shown to be associated with cardiovascular disease, independent of age, sex, inflammatory markers, and other cardiovascular disease risk factors, in the chronic kidney disease patients

  9. Infection with C. trachomatis disturbs TNFR1 signalling specifically at the level of receptor internalization.

  10. Data suggest that TRAF2 (TNF receptor-associated factor 2 (显示 TRAF2 蛋白)) negatively regulates (1) TNFR1- (tumor necrosis factor binding protein 1)-induced apoptosis, (2) TNFR2 (显示 TNFRSF1B 蛋白)- (tumor necrosis factor (显示 TNF 蛋白) receptor type 2)-induced non-canonical NFkappaB (显示 NFKB1 蛋白) signaling, and (3) TNF- (tumor necrosis factor (显示 TNF 蛋白))-induced necroptosis. [REVIEW]

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. impaired TNF (显示 TNF 蛋白)/TNFR2 (显示 TNFRSF1B 蛋白) signaling enhances Th2 and Th17 polarization and aggravates allergic airway inflammation.

  2. TNFR2 (显示 TNFRSF1B 蛋白) activation exerted beneficial effects on OPA1 expression in an aortic constriction model.

  3. Following activation by transmembrane TNF (显示 TNF 蛋白), TNFR2 (显示 TNFRSF1B 蛋白) initiates pathways that drive oligodendrocytes into a reparative mode contributing to remyelination following disease

  4. The apoptotic signals through TNFR1 appear critical for the pathogenesis of pulmonary emphysema.

  5. In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression

  6. TNFR1 signaling in myeloid-derived cells is a critical mediator of both the detrimental and the protective functions of TNF (显示 TNF 蛋白) in T cell-induced hepatitis and bacterial infection, respectively.

  7. TNF (显示 TNF 蛋白) plays an inhibitory role in modulating myocardial SDF-1 (显示 CXCL12 蛋白) production and blockade of TNF (显示 TNF 蛋白) signaling by ablation of TNFR1 and TNFR2 (显示 TNFRSF1B 蛋白) genes increased SDF-1 (显示 CXCL12 蛋白) expression in the heart. These data expand on TNF (显示 TNF 蛋白) signaling-initiated mechanisms in myocardium, which may lend a more complete understanding of SDF-1 (显示 CXCL12 蛋白) and TNFR-derived actions in hopes of advancing ischemic heart injury treatments.

  8. Results suggest that elevated TNF (显示 TNF 蛋白) in the heart, via TNFR1 and TNFR2 (显示 TNFRSF1B 蛋白), restrains cardiomyocyte differentiation of resident cardiac stem cells and may enhance adrenergic activation, both effects that would reduce the effectiveness of endogenous cardiac repair and the response to exogenous stem cell therapy, while promoting adverse cardiac remodeling.

  9. Suggest an atheroprotective role of ADAM17 (显示 ADAM17 蛋白), which might be mediated by cleaving membrane-bound TNFalpha (显示 TNF 蛋白) and TNFR2 (显示 TNFRSF1B 蛋白), thereby preventing overactivation of endogenous TNFR2 (显示 TNFRSF1B 蛋白) signaling in cells of the vasculature.

  10. Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord, they initiate expression of the cytokine TNFalpha (显示 TNF 蛋白). This induction coincides with ensheathment of these axons by associated glia via a TNF (显示 TNF 蛋白) receptor 2 (TNFR2 (显示 TNFRSF1B 蛋白))-mediated process.

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. Retinal ischemia results in increased expression of TNF-alpha (显示 TNF 蛋白) and its receptors (TNF-R1 and TNF-R2 (显示 TNFRSF1B 蛋白)).

Cow (Bovine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. These results suggest that TNF-alpha (显示 TNF 蛋白) sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII (显示 TNFRSF1B 蛋白) are present in the luteal cells of the bovine corpus luteum.

  2. The expression and cellular localization of tumor necrosis factor-alpha (TNF (显示 TNF 蛋白)) and its receptors (TNFRI and TNFRII (显示 TNFRSF1B 蛋白)) mRNAs and proteins, were determined.

  3. The upregulation of TNFRI mRNA expression by IFNG (显示 IFNG 蛋白) suggests that TNF (显示 TNF 蛋白) and IFNG (显示 IFNG 蛋白) synergistically affect the death of luteal endothelial cells resulting in acute luteolysis

  4. TNF (显示 TNF 蛋白) binding induces release of AIP1 (DAB2IP (显示 DAB2IP 蛋白)) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD (显示 TRADD 蛋白), RIP1 (显示 RALBP1 蛋白), TRAF2 (显示 TRAF2 蛋白), and AIPl.

Zebrafish Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. Targeted gene knockdown of TNFRSF1B (显示 TNFRSF1B 蛋白) in zebrafish embryos results in the induction of a caspase-8 (显示 CASP8 蛋白), caspase-2 (显示 CASP2 蛋白) and P53 (显示 TP53 蛋白)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (显示 CASP3 蛋白).

蛋白简介TNFRSF1A

蛋白简介

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

Alternative names and synonyms associated with TNFRSF1A

  • tumor necrosis factor receptor superfamily, member 1A (tnfrsf1a)
  • tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)
  • tumor necrosis factor receptor superfamily, member 1a (Tnfrsf1a)
  • tumor necrosis factor receptor superfamily, member 1A (Tnfrsf1a)
  • tumor necrosis factor receptor superfamily, member 1a (tnfrsf1a)
  • CD120a 蛋白
  • FPF 蛋白
  • MS5 蛋白
  • p55 蛋白
  • p55-R 蛋白
  • p60 蛋白
  • TBP1 蛋白
  • TNF-alphaR1 蛋白
  • TNF-R 蛋白
  • TNF-R-I 蛋白
  • TNF-R1 蛋白
  • TNF-R55 蛋白
  • TNFalpha-R1 蛋白
  • TNFAR 蛋白
  • Tnfr-2 蛋白
  • Tnfr1 蛋白
  • TNFR1-d2 蛋白
  • TNFR55 蛋白
  • TNFR60 蛋白
  • TNFR I 蛋白
  • TNFRI 蛋白
  • TNFRp55 蛋白
  • TNFRSF1A 蛋白
  • wu:fj65b10 蛋白
  • xtnfr1 蛋白
  • zgc:85914 蛋白

Protein level used designations for TNFRSF1A

tumor necrosis factor receptor 1 , tumor necrosis factor receptor p60 , tumor necrosis factor receptor superfamily member 1A , tumor necrosis factor type I , tumor necrosis factor receptor superfamily, member 1A , tumor necrosis factor receptor superfamily member 1A-like , TNF-R1 , TNF-RI , TNFR-I , tumor necrosis factor binding protein 1 , tumor necrosis factor receptor 1A isoform beta , tumor necrosis factor receptor type 1 , tumor necrosis factor-alpha receptor , TNF receptor alpha chain , TNF-alpha-R1 , p60 , tumor necrosis factor receptor type I , p55 , p55 TNF receptor , TNF Receptor 1 (TR1) , TNFR1

GENE ID SPECIES
100137626 Xenopus laevis
100144930 Xenopus (Silurana) tropicalis
403634 Canis lupus familiaris
466934 Pan troglodytes
493957 Felis catus
722033 Macaca mulatta
100059548 Equus caballus
100135698 Ovis aries
100397418 Callithrix jacchus
7132 Homo sapiens
21937 Mus musculus
25625 Rattus norvegicus
397020 Sus scrofa
282527 Bos taurus
418325 Gallus gallus
100713890 Cavia porcellus
406471 Danio rerio
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