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interaction of TNFR1 with TNFR2 (显示 TNFRSF1B 蛋白) determines the biological characters of hypopharyngeal squamous cell carcinoma and TNFR1 may dominate this process
The highest levels of TNFR1 are independently associated with progression of renal disease and death in type 2 diabetic nephropathy.
High plasma levels of TNFR1 and TNFR2 (显示 TNFRSF1B 蛋白) were associated with incident intracerebral hemorrhage.
Renal clear cell carcinoma cells cells express increased amounts of RIPK1 (显示 RIPK1 蛋白) and RIPK3 (显示 RIPK3 蛋白) and are poised to undergo necroptosis in response to TNFR1 signaling.
TRIM28 (显示 TRIM28 蛋白) acts as a central factor in controlling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1 and -2 and VEGF receptor 2 in endothelial cells
Since mumps virus SH coimmunoprecipitated with tumor necrosis factor receptor 1 (TNFR1), RIP1 (显示 UQCRFS1 蛋白), and IRAK1 (显示 IRAK1 蛋白), we hypothesize that SH exerts its NF-kappaB (显示 NFKB1 蛋白) activation inhibitory function by interacting with TNFR1, interleukin-1 receptor type 1 (IL-1R1), and TLR3 (显示 TLR3 蛋白) complexes in the plasma membrane of infected cells.
a specific link between the penetrance of the TNFRSF1A mutation and the observed T cell phenotype, is reported.
Collectively, this study provides more insights into RELT (显示 RELT 蛋白) expression, RELT (显示 RELT 蛋白) family member function, and the mechanism of RELT (显示 RELT 蛋白)-induced death.
Burkholderia cenocepacia BcaA binds to tumor necrosis factor receptor 1.
In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression
TNF-alpha (显示 TNF 蛋白) signaling through TNFR1 is an important mechanism involved in obesity-associated defective thermogenesis.
This work uncovers a dichotomy of function for TNFR2 (显示 TNFRSF1B 蛋白) in myeloid cells, with microglial TNFR2 (显示 TNFRSF1B 蛋白) providing protective signals to contain disease and monocyte/macrophagic TNFR2 (显示 TNFRSF1B 蛋白) driving immune activation and experimental autoimmune encephalomyelitis initiation.
The deficiency of TNFRp55 promoted the development of endometriosis.
TNFalpha (显示 TNF 蛋白) enhanced murine NK cell IFNgamma production via TNFR2 (显示 TNFRSF1B 蛋白) in vitro
TNFR2 (显示 TNFRSF1B 蛋白) sensitizes macrophages for endogenous TNF (显示 TNF 蛋白)-induced TNFR1-mediated necroptosis
this study shows that epithelial TNFR1 signaling promotes mucosal repair in inflammatory bowel disease
HACE1 (显示 HACE1 蛋白) controls TNF (显示 TNF 蛋白)-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1-RIP3 kinase-necroptosis pathway.
impaired TNF (显示 TNF 蛋白)/TNFR2 (显示 TNFRSF1B 蛋白) signaling enhances Th2 and Th17 polarization and aggravates allergic airway inflammation.
TNFR2 (显示 TNFRSF1B 蛋白) activation exerted beneficial effects on OPA1 expression in an aortic constriction model.
Following activation by transmembrane TNF (显示 TNF 蛋白), TNFR2 (显示 TNFRSF1B 蛋白) initiates pathways that drive oligodendrocytes into a reparative mode contributing to remyelination following disease
Retinal ischemia results in increased expression of TNF-alpha (显示 TNF 蛋白) and its receptors (TNF-R1 and TNF-R2 (显示 TNFRSF1B 蛋白)).
These results suggest that TNF-alpha (显示 TNF 蛋白) sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII (显示 TNFRSF1B 蛋白) are present in the luteal cells of the bovine corpus luteum.
The expression and cellular localization of tumor necrosis factor-alpha (TNF (显示 TNF 蛋白)) and its receptors (TNFRI and TNFRII (显示 TNFRSF1B 蛋白)) mRNAs and proteins, were determined.
The upregulation of TNFRI mRNA expression by IFNG (显示 IFNG 蛋白) suggests that TNF (显示 TNF 蛋白) and IFNG (显示 IFNG 蛋白) synergistically affect the death of luteal endothelial cells resulting in acute luteolysis
TNF (显示 TNF 蛋白) binding induces release of AIP1 (DAB2IP (显示 DAB2IP 蛋白)) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD (显示 TRADD 蛋白), RIP1 (显示 RALBP1 蛋白), TRAF2 (显示 TRAF2 蛋白), and AIPl.
Targeted gene knockdown of TNFRSF1B (显示 TNFRSF1B 蛋白) in zebrafish embryos results in the induction of a caspase-8 (显示 CASP8 蛋白), caspase-2 (显示 CASP2 蛋白) and P53 (显示 TP53 蛋白)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (显示 CASP3 蛋白).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
, tumor necrosis factor binding protein 1
, tumor necrosis factor receptor 1A isoform beta
, tumor necrosis factor receptor superfamily member 1A
, tumor necrosis factor receptor type 1
, tumor necrosis factor-alpha receptor
, TNF receptor alpha chain
, tumor necrosis factor receptor 1
, tumor necrosis factor receptor type I
, p55 TNF receptor
, tumor necrosis factor receptor p60
, TNF Receptor 1 (TR1)
, tumor necrosis factor type I
, tumor necrosis factor receptor superfamily, member 1A
, tumor necrosis factor receptor superfamily member 1A-like