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the L341V mutation limits the critical step of SQSTM1 recruitment to the phagophore
Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ubiquitin (Ub) homeostasis, a condition termed as Ub(+) stress, that is intrinsic to Ub overexpression, heat shock or prolonged proteasomal inhibition by bortezomib, a chemotherapeutic drug.
LC3 (显示 MAP1LC3A ELISA试剂盒) and p62/SQSTM1 have roles in early-stage non-small cell lung cancer
LC3B and p62 have roles in autophagy in esophageal adenocarcinoma
ALS (显示 IGFALS ELISA试剂盒)-FTLD associated mutations of SQSTM1 disrupt Keap1 (显示 KEAP1 ELISA试剂盒) binding and disable Nrf2 (显示 GABPA ELISA试剂盒) signaling.
analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 (显示 MAP1LC3A ELISA试剂盒) using a combination of fluorescence microscopy-based biophysical approaches in living cells
ENC1 interacts with the phosphorylated p62 (显示 GTF2H1 ELISA试剂盒) to impair autophagic degradation of mutant huntingtin (显示 HTT ELISA试剂盒) protein aggregates.
CAL (显示 FBLIM1 ELISA试剂盒) suppresses the expression of pro-inflammatory cytokines via p62 (显示 GTF2H1 ELISA试剂盒)/Nrf2 (显示 GABPA ELISA试剂盒)-linked HO-1 (显示 HMOX1 ELISA试剂盒) induction in RASFs.
Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.
casein kinase 1 (显示 CSNK1A1 ELISA试剂盒) phosphorylates the SQSTM1 S349 residue when harmful proteins accumulate under HSF1 (显示 HSF1 ELISA试剂盒) stress
this study proved that SYVN1 (显示 SYVN1 ELISA试剂盒) enhances SERPINA1 (显示 SERPINA1 ELISA试剂盒)(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1 (显示 SERPINA1 ELISA试剂盒)(E342K)/ATZ cytotoxicity.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3 (显示 MAP1LC3A ELISA试剂盒)-II/Map1lc3 (显示 MAP1LC3B ELISA试剂盒) in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (显示 GTF2H1 ELISA试剂盒) and down-regulates Lc3 (显示 MAP1LC3A ELISA试剂盒)-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3 (显示 MAP1LC3A ELISA试剂盒)-II/Map1lc3 (显示 MAP1LC3B ELISA试剂盒) = microtubule-associated protein (显示 SPAG5 ELISA试剂盒) 1-light chain 3)
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
SQSTM1 dynamically associates with DNA damage foci (DDF) and regulates DNA repair.
Thyroid hormone (显示 PTH ELISA试剂盒) promotes selective autophagy via induction of DAPK2 (显示 DAPK2 ELISA试剂盒)-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
serine 351 phosphorylation of p62 (显示 GTF2H1 ELISA试剂盒) did not enhance its binding to Keap1 (显示 KEAP1 ELISA试剂盒) or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (显示 NFE2L2 ELISA试剂盒)) transcription factor in this neuronal context. Nrf2 (显示 NFE2L2 ELISA试剂盒) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (显示 NFE2L2 ELISA试剂盒) gene
Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.
Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
, sqstm1 protein
, EBI3-associated protein of 60 kDa
, EBI3-associated protein p60
, oxidative stress induced like
, phosphotyrosine independent ligand for the Lck SH2 domain p62
, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
, ubiquitin-binding protein p62
, oxidative stress induced
, PKC-zeta-interacting protein
, protein kinase C-zeta-interacting protein