PRKACA 蛋白 (PRKACA)产品概述

Full name:
Protein Kinase A, alpha 蛋白 (PRKACA)
在www.antibodies-online.cn可供18 Protein Kinase A, alpha (PRKACA) 蛋白的7不同的供货商。 再加上,我们可以发PRKACA 抗体 (113)PRKACA 试剂盒 (12)和数多这个蛋白质的别的产品。 总共150 PRKACA产品已列进来了。
别名:
Calpha, Cs-PKA, PKA, PKACA, PKCA1, PKCD, PRKAR1
列出全部蛋白 基因 基因ID UniProt
PRKACA 18747 P05132
PRKACA 5566 P17612
PRKACA 25636  

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引用最多的PRKACA 蛋白

  1. Human PRKACA Protein expressed in Baculovirus infected Insect Cells - ABIN411950 : Taskén, Solberg, Zhao, Hansson, Jahnsen, Siciliano: The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1. in Genomics 1997 (PubMed)
    Show all 3 references for 411950

  2. Human PRKACA Protein expressed in Wheat germ - ABIN1316219 : Loilome, Yooyuen, Namwat, Sithithaworn, Puapairoj, Kano, Noguchi, Miwa, Yongvanit: PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group. in Tumour biology 2012 (PubMed)

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Mouse (Murine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. study identifies a new role of Dual-AKAP1 (显示 AKAP1 蛋白) in regulating mitochondrial trafficking through Miro-2 (显示 RHOT2 蛋白), and supports a model in which PINK1 (显示 PINK1 蛋白) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity

  2. Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)

  3. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH (显示 SHH 蛋白) signaling through regulation of GLI3 (显示 GLI3 蛋白) processing.

  4. this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor (显示 CSF1R 蛋白) DNA methylation (显示 HELLS 蛋白) resulting in macrophage maturation

  5. these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf (显示 SNRPE 蛋白)-dependent p38 MAPK (显示 MAPK14 蛋白) signaling cascade.

  6. These data indicate that LPA increases CCN2 (显示 CTGF 蛋白) expression through the activation of PKC and PKA. Thus, the regulatory functions of the PKC and PKA pathways are implicated in the LPA-induced increase in CCN2 (显示 CTGF 蛋白) expression

  7. PKA phosphorylates the ATPase inhibitory factor 1 (显示 ATPIF1 蛋白) and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.

  8. Data suggest PRKAR1A (显示 PRKAR1A 蛋白) contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics.

  9. Data (including data from studies in transgenic mice) suggest that constitutive activation of Prkaca in osteoblasts is sufficient to increase bone mass, favorably modify bone architecture, and improve mechanical properties of bone.

  10. Lin28a (显示 LIN28A 蛋白) protects against DCM through PKA/ROCK2 (显示 ROCK2 蛋白) dependent pathway.

Human Protein Kinase A, alpha (PRKACA) interaction partners

  1. PRKACA mutations are present in cortisol-producing adenomas and bilateral adrenal macronodular hyperplasia. PRKACA mutation is associated with more severe autonomous cortisol secretion.

  2. Dual co-expression of human fetal Tau with PKA in Escherichia coli results in multisite Tau phosphorylation including also naturally occurring sites which were not previously considered in the context of 14-3-3 (显示 YWHAQ 蛋白) binding. Tau protein co-expressed with PKA displays tight functional interaction with 14-3-3 (显示 YWHAQ 蛋白) isoforms of a different type.

  3. This review will discuss the effects of PKA phosphorylation on wild-type CFTR (显示 CFTR 蛋白), the consequences of cystic fibrosis (显示 S100A8 蛋白) mutations on PKA phosphorylation, and the development of therapies that target PKA-mediated signaling. [review]

  4. This interaction is promoted by EPAC1 (显示 RAPGEF3 蛋白) activation, triggering its translocation to the plasma membrane and binding to NHERF1 (显示 SLC9A3R1 蛋白). Our findings identify a new CFTR (显示 CFTR 蛋白)-interacting protein and demonstrate that cAMP activates CFTR (显示 CFTR 蛋白) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1 (显示 RAPGEF3 蛋白).

  5. The inhibitory effects of BMP4 (显示 BMP4 蛋白) on PDGF (显示 PDGFA 蛋白)-induced cell proliferation, collagen synthesis, and calpain-2 (显示 CAPN2 蛋白) activation are impaired in pulmonary artery smooth muscle cells from pulmonary arterial hypertension patient.

  6. description of PRKACA mutations in 2 cases of primary aldosteronism (PA) patients: a novel variant (p.His88Asp) in a case of sudden onset of PA and a mutation (p.Leu206Arg) in context of hypokalemic aggravation of long-term hypertension; these genetic alterations were not found in a subsequent series of 120 aldosterone-producing adenomas and thereby appear to be very rare events

  7. PKA signaling is pivotal in pigmentation process itself in cultured melanoma cells, while the importance of Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling should be emphasized in the context of development and differentiation

  8. Studies indicate a functional interaction between leucine-rich repeat kinase 2 (LRRK2 (显示 LRRK2 蛋白)) and protein kinase A (PKA) cross-talk in neuron and microglia.

  9. Studies indicate the importance of the AKAP79 (显示 AKAP5 蛋白)/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (显示 CA1 蛋白) region of the hippocampus.

  10. GPER enhances melanogenesis via PKA by upregulating microphthalmia-related transcription factor-tyrosinase (显示 TYR 蛋白) in melanoma

Pig (Porcine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (显示 PRKCZ 蛋白)

  2. we demonstrate that PKA, PKC (显示 FYN 蛋白) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (显示 GSK3a 蛋白) phosphorylation which subsequently controls cell motility.

Cow (Bovine) Protein Kinase A, alpha (PRKACA) interaction partners

  1. PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1

  2. Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.

  3. structural basis of selectivity for protein kinase A in complex with Rho-kinase (显示 ROCK1 蛋白) inhibitors by x-ray crystallography

  4. Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.

蛋白简介PRKACA

蛋白简介

Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.

Alternative names and synonyms associated with PRKACA

  • protein kinase, cAMP dependent, catalytic, alpha (Prkaca)
  • protein kinase, cAMP-dependent, catalytic, alpha (PRKACA)
  • protein kinase, cAMP-dependent, catalytic, alpha (Prkaca)
  • protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B)
  • Calpha 蛋白
  • Cs-PKA 蛋白
  • PKA 蛋白
  • PKACA 蛋白
  • PKCA1 蛋白
  • PKCD 蛋白
  • PRKAR1 蛋白

Protein level used designations for Protein Kinase A, alpha 蛋白 (PRKACA)

PKA C-alpha , cAMP-dependent protein kinase catalytic subunit alpha , sperm cAMP-dependent protein kinase catalytic subunit , protein kinase A catalytic subunit , protein kinase, cAMP-dependent, catalytic, alpha , C-alpha subunit , protein kinase A , cAMP-dependent protein kinase catalytic subunit C alpha , protein kinase A alpha , cAMP-dependent protein kinase type I-beta regulatory subunit

GENE ID SPECIES
18747 Mus musculus
5566 Homo sapiens
397652 Sus scrofa
282322 Bos taurus
443094 Ovis aries
25636 Rattus norvegicus
403556 Canis lupus familiaris
5575 Homo sapiens
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