anti-MYD88 (MYD88) 抗体产品概述

Full name:
anti-Myeloid Differentiation Primary Response Gene (88) 抗体 (MYD88)
在www.antibodies-online.cn可供272 Myeloid Differentiation Primary Response Gene (88) (MYD88) 抗体的35不同的供货商。 再加上,我们可以发MYD88 试剂盒 (44)MYD88 蛋白 (26)和数多这个蛋白质的别的产品。 总共363 MYD88产品已列进来了。
别名:
CG2078, Dmel\\CG2078, DmMyd88, dMyd88, EP(2)2535, GB12344, irak-2, kra, LD20892, MGC84928, myd88, myd88d, Myd88F, NV10640, XMyD88, zgc:103541

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  1. Human Polyclonal MYD88 Primary Antibody for EIA, WB - ABIN401364 : Adachi, Kawai, Takeda, Matsumoto, Tsutsui, Sakagami, Nakanishi, Akira: Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. in Immunity 1998 (PubMed)
    Show all 5 references for 401364

  2. Human Polyclonal MYD88 Primary Antibody for IF (p), IHC (p) - ABIN736881 : Lu, Liu, Gu, Ge, Wu, Ze-Ji, Qiu, Zhang, Chao, Yu: Gene Expression Profiles Underlying Selective T-Cell-Mediated Immunity Activity of a Chinese Medicine Granule on Mice Infected with Influenza Virus H1N1. in Evidence-based complementary and alternative medicine : eCAM 2014 (PubMed)
    Show all 5 references for 736881

  3. Human Polyclonal MYD88 Primary Antibody for ICC, IF - ABIN446974 : Mijares, Wangdi, Sokol, Homer, Medzhitov, Kazmierczak: Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)
    Show all 2 references for 446974

  4. Human Monoclonal MYD88 Primary Antibody for FACS, IF - ABIN2453996 : Choi, Kim, Lee, Kim: MYD88 expression and L265P mutation in diffuse large B-cell lymphoma. in Human pathology 2013 (PubMed)
    Show all 2 references for 2453996

  5. Human Polyclonal MYD88 Primary Antibody for EIA, WB - ABIN453754 : Bannon, Davies, Collett, Warhurst: Potentiation of flagellin responses in gut epithelial cells by interferon-gamma is associated with STAT-independent regulation of MyD88 expression. in The Biochemical journal 2009 (PubMed)
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  6. Human Polyclonal MYD88 Primary Antibody for FACS, IHC (p) - ABIN652460 : Deng, Yuan, Guo, Zhu, Pan, Liu: Efficacy of atorvastatin on hippocampal neuronal damage caused by chronic intermittent hypoxia: involving TLR4 and its downstream signaling pathway. in Respiratory physiology & neurobiology 2015 (PubMed)
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  7. Human Polyclonal MYD88 Primary Antibody for WB - ABIN809502 : Abe, Hirasaka, Kagawa, Kohno, Ochi, Utsunomiya, Sakai, Ohno, Teshima-Kondo, Okumura, Oarada, Maekawa, Terao, Mills, Nikawa: Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice. in Diabetes 2013 (PubMed)

  8. Dog (Canine) Polyclonal MYD88 Primary Antibody for WB - ABIN2786657 : Dhiman, Ovsyannikova, Vierkant, Ryan, Pankratz, Jacobson, Poland: Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results. in Vaccine 2008 (PubMed)

  9. Human Polyclonal MYD88 Primary Antibody for IHC, ELISA - ABIN185362 : Li, Qin: Modulation of Toll-interleukin 1 receptor mediated signaling. in Journal of molecular medicine (Berlin, Germany) 2005 (PubMed)

更多抗MYD88的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.

  2. propose that dMyD88 is the functional homolog of TIRAP (显示 TIRAP 抗体) and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors

  3. DmMyD88 encodes an essential component of the Toll (显示 TLR4 抗体) pathway in dorsoventral pattern formation.

  4. We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.

  5. both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle (显示 IRAK1 抗体).

Zebrafish Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Fish IRF6 (显示 IRF6 抗体) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1 (显示 TBK1 抗体), suggesting that differences in the IRF6 (显示 IRF6 抗体) regulation pattern exist between lower and higher vertebrates.

  2. DrIRF1 works in concert with MyD88 to activate zebrafish IFNvarphi3 but not IFNvarphi1. These results provide insights into the evolving function of IRF1 (显示 IRF1 抗体) as a positive IFN regulator.

  3. MyD88 signaling has an important protective role during early pathogenesis.

  4. MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity.

Human Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. Here the authors show that MAL (显示 MAL 抗体) TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 (显示 TLR4 抗体) TIR domains and induce formation of MyD88 assemblies.

  2. data show that in pericytes, MyD88 and IRAK4 (显示 IRAK4 抗体) are key regulators of 2 major injury responses: inflammatory and fibrogenic.

  3. Data indicate that 64 patients (57.1%) carried the myeloid differentiation factor 88 protein (MYD88) L265P mutation and 14 patients (12.5%) carried the chemokine (C-X-C motif) receptor 4 (CXCR4) WHIM (显示 CXCR4 抗体)-like mutation.

  4. HCK (显示 HCK 抗体) represents a novel target for therapeutic development in MYD88-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88.

  5. We found an that enhanced expression of the TLR4 (显示 TLR4 抗体)-MyD88-NF-kB pathway occurs in GDM placentae, which positively correlates with heightened local IR in placentae and higher maternal hyperglycemia. The TLR4 (显示 TLR4 抗体)/MyD88/NF-kB pathway may play a potential role in the development of IR in placentae of GDM.

  6. We found that over-expression of CRNDE in astrocytes increased the expression of key factors in the toll (显示 TLR4 抗体)-like receptor signaling pathway, especially toll-like receptor-3 (显示 TLR3 抗体)-mediated MyD88-independent pathway.We speculated that CRNDE might trigger inflammation to regulate tumorigenesis and tumor development through the toll (显示 TLR4 抗体)-like receptor pathway

  7. Data suggest that, in monocytes and macrophages, the interleukin-1B- (IL1B (显示 IL1B 抗体))-stimulated trans-autophosphorylation of IRAK4 (interleukin-1 receptor-associated kinase 4 (显示 IRAK4 抗体)) is initiated by MYD88-induced dimerization of IRAK4 (显示 IRAK4 抗体). In contrast, IRAK1 (interleukin-1 receptor-associated kinase 1 (显示 IRAK1 抗体)) is inactive in unstimulated monocytes/macrophages and is converted to an active protein kinase (显示 CDK7 抗体) in response to IL1B (显示 IL1B 抗体).

  8. our data suggest a new role of MyD88 in the development of glucose intolerance and hepatic steatosis.

  9. In patient population from Southeast Serbia Myd 88 L265 mutation was not responsible for the development of diffuse large B-cell non Hodgkin lymphoma.

  10. FSTL1 (显示 FSTL1 抗体) displays anti-inflammatory effects against oxidized low-density lipoprotein-induced pro-inflammatory cytokine production via a mechanism that involves the TLR4 (显示 TLR4 抗体)/MyD88/NF-kappaB (显示 NFKB1 抗体) and MAPK (显示 MAPK1 抗体) signaling pathways.

Pig (Porcine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. These results suggest that porcine circovirus 2 induces IL-8 (显示 IL8 抗体) secretion via the TLR2 (显示 TLR2 抗体)/MyD88/NF-kappaB (显示 NFKB1 抗体) signalling pathway.

  2. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88.

  3. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.

Cow (Bovine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. L. rhamnosus GR-1 ameliorates the E. coli-induced disruption of cellular ultrastructure, subsequently reducing the percentage of bovine endometrial epithelial cells apoptosis and limiting inflammatory responses, partly via attenuation of MyD88-dependent and MyD88-independent pathway activation

  2. Modulated cytokine expression in Bovine viral diarrhea virus type 2 infected macrophages was associated with decreased MyD88 expression.

  3. The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis.

  4. MyD88 plays a functional role in transducing LPS (显示 IRF6 抗体) signaling from TLR-4 (显示 TLR4 抗体) to downstream effector molecules involved in NF-kappaB (显示 NFKB1 抗体) activation

Atlantic Salmon (Salmo salar) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. MyD88 interacts with interferon (显示 IFNA 抗体) regulatory factor (IRF) 3 (显示 IRF3 抗体) and IRF7 (显示 IRF7 抗体) in Atlantic salmon (Salmo salar)

  2. the salmon MyD88 was cloned and its expression was analysed.

Mouse (Murine) Myeloid Differentiation Primary Response Gene (88) (MYD88) interaction partners

  1. These data show that the normal distribution of surface glycosylation requires IL-1R, but not MyD88, and is not sufficient to prevent bacterial binding.

  2. data show that in pericytes, MyD88 and IRAK4 (显示 IRAK4 抗体) are key regulators of 2 major injury responses: inflammatory and fibrogenic.

  3. TLR4 (显示 TLR4 抗体) agonist MPLA potently induced MyD88-dependent signaling. Neutrophil recruitment after multiple injections of MPLA was reliant on MyD88-dependent signaling. MPLA treatment induced expansion of myeloid progenitors in bone marrow and upregulation of CD11b (显示 ITGAM 抗体) and shedding of L-selectin (显示 SELL 抗体) by neutrophils, all of which were attenuated in MyD88-deficient mice.

  4. Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3 (显示 TLR3 抗体)/7/9 in macrophages; macrophages deficient for Tlr3 (显示 TLR3 抗体)/7/9, Unc93b1 (显示 UNC93B1 抗体), or MyD88 fail to undergo L. major-induced autophagy. (TLR = Toll (显示 TLR4 抗体)-like receptor; Unc93b1 (显示 UNC93B1 抗体) = unc-93 (显示 UNC93B1 抗体) homolog B1; MyD88 = myeloid differentiation primary response gene 88)

  5. MyD88 inhibitor ST2825 attenuates acute cardiac rejection and promotes donor-specific hyporesponsiveness in stringent skin transplant models

  6. MyD88 has a divergent requirement for cell survival in non-Tregs and Tregs, and a yet-to-be defined survival-independent requirement for Treg function during the response to alloantigen

  7. The aim of this study was to examine the role of the common TLR adaptor protein myeloid-differentiation factor (MyD) 88 in lung epithelium during host defense against K. pneumoniae-induced pneumonia.

  8. TLR2 (显示 TLR2 抗体), TLR4 (显示 TLR4 抗体) AND MyD88 mediate allergic airway disease (AAD) and Streptococcus pneumoniae-induced suppression of AAD.

  9. miR (显示 MLXIP 抗体)-23a-5p modulated the innate host defense by promoting mycobacteria survival and inhibiting the activation of autophagy against Mycobacterium tuberculosis through TLR2 (显示 TLR2 抗体)/MyD88/NF-kappaB (显示 NFKB1 抗体) pathway by targeting TLR2 (显示 TLR2 抗体).

  10. results indicate that the R753Q polymorphism alters TLR2 (显示 TLR2 抗体) signaling competence, leading to impaired MyD88-TLR2 (显示 TLR2 抗体) assembly, reduced phosphorylation of IRAK-1 (显示 IRAK1 抗体), diminished activation of MAPKs and NF-kappaB (显示 NFKB1 抗体), and deficient induction of cytokines in macrophages infected with M. smegmatis.

MYD88 抗原简介

Antigen Summary

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with MYD88

  • myeloid differentiation primary response 88 (MYD88) 抗体
  • interleukin-1 receptor-associated kinase 2 (irak2) 抗体
  • interleukin-1 receptor-associated kinase 2 (IRAK2) 抗体
  • interleukin-1 receptor-associated kinase 2 (LOC100228175) 抗体
  • myeloid differentiation primary response gene (88) (myd88-b) 抗体
  • myeloid differentiation primary response gene 88 (Myd88) 抗体
  • CG2078 gene product from transcript CG2078-RB (Myd88) 抗体
  • myeloid differentiation primary response 88 (Myd88) 抗体
  • myeloid differentiation primary response gene (88) (MYD88) 抗体
  • myeloid differentiation primary response gene (88) (myd88) 抗体
  • myeloid differentiation primary response factor 88 (Myd88) 抗体
  • myeloid differentiation primary response 88 (myd88) 抗体
  • MyD88 adaptor (myd88) 抗体
  • myeloid differentiation factor 88 (myd88) 抗体
  • myeloid differentiation response protein 88 (myd88) 抗体
  • myeloid differentiation primary response gene 88 (myd88) 抗体
  • CG2078 抗体
  • Dmel\\CG2078 抗体
  • DmMyd88 抗体
  • dMyd88 抗体
  • EP(2)2535 抗体
  • GB12344 抗体
  • irak-2 抗体
  • kra 抗体
  • LD20892 抗体
  • MGC84928 抗体
  • myd88 抗体
  • myd88d 抗体
  • Myd88F 抗体
  • NV10640 抗体
  • XMyD88 抗体
  • zgc:103541 抗体

Protein level used designations for MYD88

myeloid differentiation primary response gene (88) , myeloid differentiation primary response protein MyD88 , interleukin-1 receptor-associated kinase-like 2 , interleukin-1 receptor-associated kinase 2 , myeloid differentiation primary response protein MyD88-B , Toll/IL-1 receptor binding protein MyD88-B , CG2078-PA , CG2078-PB , Myd88-PA , Myd88-PB , Myd88F , krapfen , myeloid differentiation primary response gene 88 , myeloid differentiation primary response factor 88 , zMyD88 , myeloid differentiation factor 88 , myeloid differentiation primary response protein 88 , myeloid differentiation response protein 88

GENE ID SPECIES
4615 Homo sapiens
493227 Xenopus (Silurana) tropicalis
416118 Gallus gallus
100228175 Taeniopygia guttata
734302 Xenopus laevis
17874 Mus musculus
35956 Drosophila melanogaster
301059 Rattus norvegicus
396646 Sus scrofa
403145 Danio rerio
413194 Apis mellifera
420420 Gallus gallus
444881 Bos taurus
460269 Pan troglodytes
477024 Canis lupus familiaris
549591 Xenopus (Silurana) tropicalis
678682 Ovis aries
696494 Macaca mulatta
100118553 Nasonia vitripennis
100134853 Takifugu rubripes
100136123 Oncorhynchus mykiss
100169859 Salmo salar
100305041 Ictalurus punctatus
100616081 Amphimedon queenslandica
575153 Strongylocentrotus purpuratus
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