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report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling nodes TRAF2 (显示 TRAF2 ELISA试剂盒), TRAF3 (显示 TRAF3 ELISA试剂盒), IKKalpha (显示 CHUK ELISA试剂盒), NIK, and NF-kappaB2/p100 (显示 CUX1 ELISA试剂盒); also provide a differential interactome of NIK mutants that cause immunodeficiency
OLFM1 (显示 OLFM1 ELISA试剂盒) is a negative regulator of non-canonical NF-kappaB (显示 NFKB1 ELISA试剂盒) signalling by interacting with and inhibiting NIK. Thus, OLFM1 (显示 OLFM1 ELISA试剂盒) may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (显示 CALR ELISA试剂盒)) patients.
Results reveal that endothelial Map4k4 (显示 MAP4K4 ELISA试剂盒) is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.
of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 (显示 MAP4K4 ELISA试剂盒) gene is associated with T2DM in a Chinese Han population, and MAP4K4 (显示 MAP4K4 ELISA试剂盒) gene variants may contribute to the risk toward the development of T2DM
The expression of OTUD7B and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM (显示 ODZ1 ELISA试剂盒) stage. high OTUD7B/low NIK index can predict an good prognosis.
Interactions between MAP4K4 (显示 MAP4K4 ELISA试剂盒) gene variants and environmental factors may contribute to MAP4K4 (显示 MAP4K4 ELISA试剂盒) attenuation in T cells, leading to non-obese T2D.
MAP4K4 (显示 MAP4K4 ELISA试剂盒) promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells
NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.
miR (显示 MLXIP ELISA试剂盒)-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4 (显示 MAP4K4 ELISA试剂盒)
The results of the present study suggested that inhibition of MAP4K4 (显示 MAP4K4 ELISA试剂盒) may be a therapeutic strategy for gastric cancer.
NIK (显示 MAP4K4 ELISA试剂盒) pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity.
this study demonstrates that although NIK (显示 MAP4K4 ELISA试剂盒) is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells
Using a novel conditional mutant of NIK (显示 MAP4K4 ELISA试剂盒), the authors could show in vivo that NIK (显示 MAP4K4 ELISA试剂盒) signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.
NIK (显示 MAP4K4 ELISA试剂盒) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (显示 TNFRSF1A ELISA试剂盒)/RIP1 (显示 RALBP1 ELISA试剂盒)-dependent cell death independently of the alternative NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway.
This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.
results assign NIK (显示 MAP4K4 ELISA试剂盒)-induced alternative NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined
NIK (显示 MAP4K4 ELISA试剂盒), and thus probably the noncanonical NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 (显示 CD8A ELISA试剂盒) T cells after exposure to licensing stimuli.
Deletion of NIK (显示 MAP4K4 ELISA试剂盒) in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF (显示 TNFSF13B ELISA试剂盒).
We identify NIK (显示 MAP4K4 ELISA试剂盒) as a critical negative regulator of beta cell function, as pharmacological NIK (显示 MAP4K4 ELISA试剂盒) activation results in impaired glucose-stimulated insulin (显示 INS ELISA试剂盒) secretion in mouse and human islets.
the NIK (显示 MAP4K4 ELISA试剂盒) in thymic stroma may be critically involved in the differentiation of most NKT (显示 CTSL1 ELISA试剂盒) cell subsets (although the level of NIK (显示 MAP4K4 ELISA试剂盒) dependence may vary among the subsets), and also the NIK (显示 MAP4K4 ELISA试剂盒) in NKT (显示 CTSL1 ELISA试剂盒)-alphabeta cells may be dispensable for their effector function.
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
, serine/threonine protein-kinase
, serine/threonine-protein kinase NIK
, NF kappa B-inducing kinase
, Nfkb inducing kinase
, protein kinase
, mitogen-activated protein kinase kinase kinase 14