anti-IKBKG (IKBKG) 抗体产品概述

Full name:
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma 抗体 (IKBKG)
在www.antibodies-online.cn可供339 Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) 抗体的31不同的供货商。 再加上,我们可以发IKBKG 试剂盒 (16)IKBKG 蛋白 (11)和数多这个蛋白质的别的产品。 总共384 IKBKG产品已列进来了。
别名:
1110037D23Rik, AI848108, AI851264, AMCBX1, AW124339, CG16910, dIKK, dIKK-gamma, Dmel\\CG16910, DmIKK-gamma, dmIKKgamma, FIP-3, FIP3, Fip3p, fj33c07, IKBKG, IKBKG_1, IKBKG_2, IKK, IKK-gamma, IKKg, IKKgamma, IKK[g], IKK[[gamma]], IP, IP1, IP2, IPD2, Kenny, Key, MGC97885, Nemo, wu:fj33c07, ZC2HC9, zgc:113492

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引用最多的anti-IKBKG 抗体

  1. Human Monoclonal IKBKG Primary Antibody for SimWes, WB - ABIN252501 : Wunderlich, Luedde, Singer, Schmidt-Supprian, Baumgartl, Schirmacher, Pasparakis, Brüning: Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 7 references for 252501

  2. Human Monoclonal IKBKG Primary Antibody for WB - ABIN387828 : Mooster, Cancrini, Simonetti, Rossi, Di Matteo, Romiti, Di Cesare, Notarangelo, Geha, McDonald: Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. in The Journal of allergy and clinical immunology 2010 (PubMed)
    Show all 6 references for 387828

  3. Human Monoclonal IKBKG Primary Antibody for FACS, WB - ABIN252492 : Harhaj, Sun: IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for 252492

  4. Human Monoclonal IKBKG Primary Antibody for IHC (p), IP - ABIN567775 : Iha, Kibler, Yedavalli, Peloponese, Haller, Miyazato, Kasai, Jeang: Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling. in Oncogene 2003 (PubMed)
    Show all 2 references for 567775

  5. Human Polyclonal IKBKG Primary Antibody for ELISA, WB - ABIN1534228 : Xiao, Sun: Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein. in Oncogene 2000 (PubMed)

  6. Human Polyclonal IKBKG Primary Antibody for IF, ELISA - ABIN1532742 : Rothwarf, Zandi, Natoli, Karin: IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. in Nature 1998 (PubMed)

  7. Cow (Bovine) Polyclonal IKBKG Primary Antibody for WB - ABIN2779232 : Hai, Yeung, Wood, Wei, Yamaoka, Gatalica, Jeang, Brasier: An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation. in Journal of virology 2006 (PubMed)

  8. Cow (Bovine) Polyclonal IKBKG Primary Antibody for WB - ABIN2779233 : Salminen, Suuronen, Huuskonen, Kaarniranta: NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes? in Biochemical and biophysical research communications 2008 (PubMed)

更多抗IKBKG的相互作用对抗体

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Authors show that NEMO stabilizes HIFalpha via direct interaction and independently of NF-kappaB (显示 NFKB1 抗体) signaling in vitro. NEMO prolongs tumor cell survival via regulation of apoptosis and activation of epithelial-to-mesenchymal transition, facilitating tumor metastasis.

  2. The results demonstrate the the first example of father-to-daughter transmission of IP in which a pathogenic mutation in IKBKG has been demonstrated

  3. Molluscum contagiosum virus MC005 inhibited NF-kappaB (显示 NFKB1 抗体) proximal to the IkappaB kinase (显示 CHUK 抗体) (IKK (显示 CHUK 抗体)) complex, and unbiased affinity purification revealed that MC005 interacts with the IKK (显示 CHUK 抗体) subunit NEMO (NF-kappaB (显示 NFKB1 抗体) essential modulator).

  4. These data suggest that molluscum contagiosum virus MC159 competitively binds to NEMO to prevent cIAP1 (显示 BIRC2 抗体)-induced NEMO polyubiquitination.

  5. High IKBKG expression is associated with multiple myeloma.

  6. Our findings shed light on the nature of the interaction between NEMO and poly-ubiquitin, suggesting that NEMO is differentially regulated by poly-ubiquitin chain length and that this regulation occurs via a modulation of the available equilibrium of conformational states, rather than gross structural change

  7. FADD (显示 FADD 抗体), as well as NEMO, is a substrate for LUBAC ubiquitin ligase (E3) complex, composed of the HOIP (显示 RNF31 抗体), HOIL-1L (显示 RBCK1 抗体), and SHARPIN (显示 SHARPIN 抗体) subunits.

  8. Consistent with experimental evidence, the zinc ion is essential for mechanical stabilization of the functional, folded conformation of NEMO.

  9. Autoubiquitination of TRIM26 (显示 TRIM26 抗体) links TBK1 (显示 TBK1 抗体) to NEMO in RLR (显示 DHX58 抗体)-mediated innate antiviral immune response

  10. Herein, our simulations of the zinc finger NEMO (2JVX) using multiple simulations of length 15, 30, 1000, and 3000 ns are analyzed to provide clarity on this point.

Pig (Porcine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Porcine deltacoronavirus nsp5 (显示 SPECC1 抗体), the 3C-like protease, inhibits interferon-beta (显示 IFNB1 抗体) production through the cleavage of NEMO.

  2. Nsp4 interfered with the NF-kappaB (显示 NFKB1 抗体) signaling pathway through the cleavage of IKBKG at the E349-S350 site, leading to the downregulation of IFN-beta (显示 IFNB1 抗体) production.

  3. Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling.

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. lymphocyte-specific deletion of IKK2 (显示 IKBKB 抗体) or NEMO aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.

  2. Whereas Parkin (显示 PARK2 抗体) has been reported to positively regulate the expression of OPA1 (显示 MED12 抗体) through NEMO, herein we found that PARK2 (显示 PARK2 抗体) overexpression did not modify the expression of OPA1 (显示 MED12 抗体).

  3. prevents colon inflammation by NF-kappaB (显示 NFKB1 抗体)-independent functions

  4. Thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span.

  5. SENP1 (显示 SENP1 抗体) deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB (显示 NFKB1 抗体) activity, cytokine production and pancreatic inflammation.

  6. Crucial functions of inflammatory TAK1 (显示 NR2C2 抗体)-NEMO signaling in protecting the brain endothelium and maintaining normal brain function.

  7. Data show that NEMO protein prevents hepatocarcinogenesis by inhibiting receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1 (显示 RIPK1 抗体)) kinase activity-driven hepatocyte apoptosis.

  8. Data show that the in utero death of NF-NF (显示 NFASC 抗体)-kappaB (显示 NFKB1 抗体) essential modulator (NEMO) and cylindromatosis protein double mutant mice is mediated by TNF (显示 TNF 抗体) receptor 1 (TNFR1 (显示 TNFRSF1A 抗体)) signaling and can be rescued by TNFR1 (显示 TNFRSF1A 抗体) deficiency.

  9. signaling through NEMO might not only be involved in the production of NF-kappaB (显示 NFKB1 抗体) proinflammatory chemokines but also regulates podocyte dynamics independently of NF-kappaB (显示 NFKB1 抗体)

  10. The stability of the NEMO coiled coil is maintained by strong interhelix interactions in the region centered on residue 54.

IKBKG 抗原简介

Antigen Summary

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

Alternative names and synonyms associated with IKBKG

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (ikbkg) 抗体
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG) 抗体
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (LOC782205) 抗体
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG_1) 抗体
  • kenny (key) 抗体
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (Ikbkg) 抗体
  • inhibitor of kappaB kinase gamma (Ikbkg) 抗体
  • 1110037D23Rik 抗体
  • AI848108 抗体
  • AI851264 抗体
  • AMCBX1 抗体
  • AW124339 抗体
  • CG16910 抗体
  • dIKK 抗体
  • dIKK-gamma 抗体
  • Dmel\\CG16910 抗体
  • DmIKK-gamma 抗体
  • dmIKKgamma 抗体
  • FIP-3 抗体
  • FIP3 抗体
  • Fip3p 抗体
  • fj33c07 抗体
  • IKBKG 抗体
  • IKBKG_1 抗体
  • IKBKG_2 抗体
  • IKK 抗体
  • IKK-gamma 抗体
  • IKKg 抗体
  • IKKgamma 抗体
  • IKK[g] 抗体
  • IKK[[gamma]] 抗体
  • IP 抗体
  • IP1 抗体
  • IP2 抗体
  • IPD2 抗体
  • Kenny 抗体
  • Key 抗体
  • MGC97885 抗体
  • Nemo 抗体
  • wu:fj33c07 抗体
  • ZC2HC9 抗体
  • zgc:113492 抗体

Protein level used designations for IKBKG

NF-kappa-B essential modulator , ikky , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 1 , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 2 , NF-kappa-B essential modulator-like , CG16910-PA , CG16910-PB , key-PA , key-PB , I-kappa-B kinase subunit gamma , IKKAP1 , IKKG , IkB kinase gamma subunit , NF-kappa-B essential modifier , NFkappaB essential modulator , ikB kinase subunit gamma , ikB kinase-associated protein 1 , incontinentia pigmenti , inhibitor of nuclear factor kappa-B kinase subunit gamma , I-kappa-B kinase gamma , IKK-gamma , NEMO , NF-kappa B essential modulator , inhibitor of kappaB kinase gamma , mFIP-3

GENE ID SPECIES
541530 Danio rerio
701237 Macaca mulatta
735069 Xenopus laevis
743415 Pan troglodytes
782205 Bos taurus
100137553 Papio anubis
100145270 Xenopus (Silurana) tropicalis
100470223 Ailuropoda melanoleuca
37967 Drosophila melanogaster
8517 Homo sapiens
612576 Canis lupus familiaris
100127355 Sus scrofa
281855 Bos taurus
100328905 Oryctolagus cuniculus
309295 Rattus norvegicus
16151 Mus musculus
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