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Human EGFR ELISA Kit for Cell ELISA - ABIN1981827
Hubbard, Wei, Ellis, Hendrickson: Crystal structure of the tyrosine kinase domain of the human insulin receptor. in Nature 1995
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Human EGFR ELISA Kit for Cell ELISA - ABIN1981825
Hackel, Zwick, Prenzel, Ullrich: Epidermal growth factor receptors: critical mediators of multiple receptor pathways. in Current opinion in cell biology 1999
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Human EGFR ELISA Kit for Sandwich ELISA - ABIN411266
Achmad, Hanaoka, Yoshioka, Yamamoto, Tominaga, Araki, Ohshima, Oriuchi, Endo: Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography. in Cancer science 2012
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Human EGFR ELISA Kit for Sandwich ELISA - ABIN417184
Russo: Increased Epidermal Growth Factor Receptor (EGFR) Associated with Hepatocyte Growth Factor (HGF) and Symptom Severity in Children with Autism Spectrum Disorders (ASDs). in Journal of central nervous system disease 2014
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Human EGFR ELISA Kit for Sandwich ELISA - ABIN625223
Maurya, Rai, Rai, Deshpande, Jain, Mudiam, Prabhakar, Bandyopadhyay: Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling. in Toxicological sciences : an official journal of the Society of Toxicology 2012
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Human EGFR ELISA Kit for Cell ELISA - ABIN1981821
Wang, Patil, Li, Humphrey, Brattain, Howell: Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. in Oncogene 2002
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Human EGFR ELISA Kit for Sandwich ELISA - ABIN624965
Maramotti, Paci, Miccichè, Ciarrocchi, Cavazza, De Bortoli, Vaghi, Formisano, Canovi, Sgarbi, Bongarzone: Soluble epidermal growth factor receptor isoforms in non-small cell lung cancer tissue and in blood. in Lung cancer (Amsterdam, Netherlands) 2012
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Human EGFR ELISA Kit for Cell ELISA - ABIN1981823
Biscardi, Maa, Tice, Cox, Leu, Parsons: c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. in The Journal of biological chemistry 1999
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Human EGFR ELISA Kit for Cell ELISA - ABIN1981829
Kanai, Konda, Nakajima, Izumi, Kanda, Nanakin, Kubohara, Chiba: Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. in Oncogene 2003
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Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (显示 ERBB2 ELISA试剂盒)).
Graf (显示 ARHGAP26 ELISA试剂盒) functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro (显示 CXCL1 ELISA试剂盒) is antagonized by EGFR signaling, which inhibits Gro (显示 CXCL1 ELISA试剂盒)-dependent repression via p-ERK (显示 MAPK1 ELISA试剂盒) mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam (显示 STAM ELISA试剂盒) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (显示 TGFb ELISA试剂盒) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (显示 MAPK8 ELISA试剂盒) signaling
Loss of Usp5 (显示 USP5 ELISA试剂盒) results in upregulation of Notch (显示 NOTCH1 ELISA试剂盒) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (显示 AKT1 ELISA试剂盒)/ERK (显示 MAPK1 ELISA试剂盒) pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Study demonstrated that IGF-I (显示 IGF1 ELISA试剂盒) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 (显示 PGRMC1 ELISA试剂盒) signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper (显示 GPER ELISA试剂盒).
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
EGFR gene amplification and mutations are rare in triple-negative breast cancer (TNBC), the latter of no apparent clinical relevance. Surrogate markers of EGFR-related chromosomal aberrations and combined EGFR/p53 (显示 TP53 ELISA试剂盒) IHC phenotypes appear to be associated with favorable prognosis in patients with operable TNBC receiving conventional adjuvant chemotherapy.
EGFR gene copy number is a biomarker for response to EGFR-tyrosine kinase (显示 TXK ELISA试剂盒) inhibitor therapy in patients with advanced non-small-cell lung cancer.
Osimertinib reduces PD-L1 (显示 CD274 ELISA试剂盒) mRNA expression and induces its protein degradation, suggesting that osimertinib may reactivate the immune activity of T cells in the tumor microenvironment in EGFR-mutated NSCLC patients.
There is a higher incidence of brain metastases for patients with EGFR+ metastatic non-small cell lung cancer, even when adjusted for differences in survival, compared to EGFR wild type.
EGFR expression was associated with shorter cancer-specific overall survival. Our finding suggests EGFR is a useful prognostic marker of patients with distal extrahepatic bile duct (EBD (显示 DEFB1 ELISA试剂盒)) carcinoma.
MET/T790M-positive patients are at higher risk of acquired resistance to EGFR-Tyrosine kinase (显示 TXK ELISA试剂盒) inhibitors, and have a worse Post-progression survival than patients with only MET overexpression or the T790M mutation alone. Clinical trials are needed to determine the best treatment for patients with both MET overexpression and the EGFR T790M mutation.
the EGFR/STAT3 (显示 STAT3 ELISA试剂盒) pathway contributed to CDDP-induced CEBPD (显示 CEBPD ELISA试剂盒) expression in UCUB cells. Gefitinib and S3I-201 treatment significantly reduced the expression of CEBPD (显示 CEBPD ELISA试剂盒) and enhanced the sensitivity of CDDP-resistant UCUB cells to CDDP and paclitaxel
EGFR rs11506105 is strongly associated with treatment responses in Iranian patients with chronic hepatitis C.
EGR1 (显示 EGR1 ELISA试剂盒) is a key player in the transcriptional control of miR (显示 MLXIP ELISA试剂盒)-203a, and that miR (显示 MLXIP ELISA试剂盒)-203a acts as an anti-oncogene (显示 RAB1A ELISA试剂盒) to suppress HCC (显示 FAM126A ELISA试剂盒) tumorigenesis by targeting HOXD3 (显示 HOXD3 ELISA试剂盒) through EGFR-related cell signaling pathways.
The long noncoding RNA CAR intergenic 10 bound and stabilized transcription factor Y-box-binding protein 1 (YB-1 (显示 YBX1 ELISA试剂盒)), leading to up-regulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells.
These results suggest that EphA2/Efna1/Egfr genes, linked to a possible control by miR-200a and miR-26b, could be proposed as novel CRC prognostic biomarkers. Moreover, EphA2 could be linked to a mechanism of resistance to cetuximab alternative to KRAS mutations.
These results collectively suggest that sustained activation of Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling.
Epidermal growth factor receptor (EGFR) signaling enhances miR (显示 MLXIP ELISA试剂盒)-29 expression in glioblastoma cells via upregulation of Sterol regulatory element binding protein 1 (显示 SREBF1 ELISA试剂盒)
YAP (显示 YAP1 ELISA试剂盒) accumulated in nuclei of mammary glands in ErbB2 (显示 ERBB2 ELISA试剂盒)/EGFR-transgenic mice, suggesting that EGFR signaling affects YAP (显示 YAP1 ELISA试剂盒) in vivo similar to cell culture. ErbB2 (显示 ERBB2 ELISA试剂盒)/EGFR-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Findings suggest that sEGFR might be a biomarker for evaluating insulin (显示 INS ELISA试剂盒) resistance or a therapeutic target of liraglutide.
Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR-ligands by differentially activating ADAM17 (显示 ADAM17 ELISA试剂盒) or ADAM10 (显示 ADAM10 ELISA试剂盒).
Data suggest that simultaneous inhibition of mTOR (显示 FRAP1 ELISA试剂盒) and EGFR or MEK (显示 MDK ELISA试剂盒) may be more effective in treating colon cancer.
Data indicate alpha-P85 (显示 ECM1 ELISA试剂盒) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR) expression and cell malignant transformation via nucleolin (显示 NCL ELISA试剂盒)-dependent mechanism.
through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers.
OLIG2 (显示 OLIG2 ELISA试剂盒) modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR) or platelet-derived growth factor receptor alpha (显示 PDGFRA ELISA试剂盒).
this study shows that anemonin may ameliorate LPS (显示 IRF6 ELISA试剂盒)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 (显示 SDC4 ELISA试剂盒) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF (显示 EGF ELISA试剂盒) induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (显示 NOS1 ELISA试剂盒)-derived nitric oxide.
EGFR, VEGFR (显示 KDR ELISA试剂盒) and FGFR (显示 FGFR2 ELISA试剂盒) are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF (显示 EGF ELISA试剂盒) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (显示 EGF ELISA试剂盒) and its receptor on the uterine artery and the region supplying these vessels.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (显示 EGF ELISA试剂盒) (human recombinant EGF (显示 EGF ELISA试剂盒)) alone or with EGF (显示 EGF ELISA试剂盒) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (显示 EGF ELISA试剂盒) on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src (显示 SRC ELISA试剂盒) and PI3K to amplify the oxytocin signaling to increase the output of PGF (显示 PGF ELISA试剂盒)(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF (显示 EGF ELISA试剂盒)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF (显示 EGF ELISA试剂盒)) and EGF (显示 EGF ELISA试剂盒) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP (显示 MMP14 ELISA试剂盒) has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF (显示 EGF ELISA试剂盒) and HGF (显示 HGF ELISA试剂盒) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1