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specificity of PDZ domain (显示 INADL ELISA试剂盒) and the molecular origin
The findings suggest a new role for STEF in Focal adhesion disassembly and cell migration through microtubules-mediated mechanisms.
STEF is an activator of cortical neuronal migration.
Extracellular and intracellular information is integrated by STEF to modulate the balance of Rho GTPase (显示 RACGAP1 ELISA试剂盒) activities in the growth cone and control growth cone behavior.
Phosphorylation of STEF by Rho-kinase (显示 ROCK2 ELISA试剂盒) exerts the inhibitory effect on the function of STEF.
Results describe the purification, crystallization and X-ray data collection of the Tiam1 and Tiam2 PH-CC-Ex regions.
Tiam2/Rac (显示 AKT1 ELISA试剂盒) are key components of EphB2 (显示 EPHB2 ELISA试剂盒) trans-endocytosis and are important for cell repulsion.
Results provide evidence that Sp1 (显示 PSG1 ELISA试剂盒) positively controls TIAM2S transcription and that Sp1 (显示 PSG1 ELISA试剂盒)-mediated transcriptional activation is essential for TIAM2S ectopic expression in liver cancer cells.
Knockdown of TIAM2 could up-regulate the expression of E-cadherin (显示 CDH1 ELISA试剂盒).
TIAM2 expression was undetectable in normal human liver but was induced in all HCC (显示 FAM126A ELISA试剂盒) cell lines and in 86% (78/91) of HCC (显示 FAM126A ELISA试剂盒) biopsies.
stef gene expressed in a stage- and region-specific manner in the mouse brain
STEF protein is a guanine nucleotide exchange factor that specifically activates Rac1 in vitro and in cultured cells, which may lead to changes in the actin cytoskeletal network.
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.
T-cell lymphoma invasion and metastasis 2
, T-lymphoma invasion and metastasis-inducing protein 2-like
, RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1
, SIF and TIAM1-like exchange factor
, T-cell lymphoma invasion and metastasis 2; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1
, T-lymphoma invasion and metastasis-inducing protein 2