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PHLPP1 抗体

(PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].
PHLPP1 抗体  (AA 1508-1717) PHLPP1 抗体  (AA 1508-1717) PHLPP1 抗体 (AA 1508-1717) (ABIN6145573)

PHLPP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

PHLPP1 抗体 PHLPP1 抗体 PHLPP1 抗体 (ABIN7130610)

PHLPP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

PHLPP1 抗体  (C-Term) PHLPP1 抗体  (C-Term) PHLPP1 抗体 (C-Term) (ABIN6264947)

PHLPP1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

PHLPP1 抗体 by 适用

Find PHLPP1 抗体 for a variety of species such as anti-Human PHLPP1, anti-Mouse PHLPP1, anti-Rat PHLPP1. The species listed below are among those available. Click on a link to go to the corresponding products.

PHLPP1 抗体 by 应用范围

Find PHLPP1 抗体 validated for a specific application such as WB, ELISA, IHC, IF. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PHLPP1 抗体 by 抗体来源

Find PHLPP1 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

PHLPP1 抗体 by 抗原表位

Find PHLPP1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

PHLPP1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal PHLPP1 抗体. Click on a link to go to the corresponding products.

PHLPP1 抗体 by 克隆

Find PHLPP1 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

PHLPP1 抗体 by 标记

Find PHLPP1 抗体 with a specific conjugate such as Alexa Fluor 488, Alexa Fluor 555, Alexa Fluor 594. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular PHLPP1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN6145573
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7130610
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6264947
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN1804212
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF
Validations
  • (1)
Cat. No. ABIN7264821
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF, IP
Validations
Cat. No. ABIN7117369
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
Cat. No. ABIN2764065
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, ICC
Validations
Cat. No. ABIN6991746
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
Cat. No. ABIN1840456
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
Cat. No. ABIN2884713
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ICC
Validations
Cat. No. ABIN603650
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN392310
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, EIA
Validations
  • (1)
Cat. No. ABIN1449987
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, EIA
Validations
  • (1)
Cat. No. ABIN360194
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application
Validations
Cat. No. ABIN6902519
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our PHLPP1 抗体

Dai, Zhang, Cheng, Yang, Chen, Liu, Wang, Yang, Jiang: "RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells." in: Carcinogenesis, (2018) (PubMed).

Fatima, Wagstaff, Loveland, Jans: "Interactome of the negative regulator of nuclear import BRCA1-binding protein 2." in: Scientific reports, Vol. 5, pp. 9459, (2015) (PubMed).

Huang, Chuang, Chou, Wang, Lee, Yang, Chiu, Kapuriya, Wang, Kulp, Chen: "Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1." in: Science signaling, Vol. 6, Issue 267, pp. ra19, (2013) (PubMed).

Liu, Stevens, Gao: "mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6510-20, (2011) (PubMed).

Warfel, Niederst, Stevens, Brennan, Frame, Newton et al.: "Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein ..." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19777-88, (2011) (PubMed).

Liu, Yang, Bu, Liu, Ding, Li, Jia: "Cell-type-specific regulation of raft-associated Akt signaling." in: Cell death & disease, Vol. 2, pp. e145, (2011) (PubMed).

Cleveland-Donovan, Maile, Tsiaras, Tchkonia, Kirkland, Boney: "IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects." in: Endocrinology, Vol. 151, Issue 8, pp. 3752-63, (2010) (PubMed).

Mistafa, Ghalali, Kadekar, Högberg, Stenius et al.: "Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN ..." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27900-10, (2010) (PubMed).

Hirano, Nakamura, Yokota, Ono, Shigeno, Fujisawa, Shinjo, Ohnishi et al.: "Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt ..." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 22155-65, (2009) (PubMed).

Brognard, Niederst, Reyes, Warfel, Newton: "Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 15215-23, (2009) (PubMed).

Aliases for PHLPP1 抗体

PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) 抗体
PH domain and leucine rich repeat protein phosphatase 1 (phlpp1) 抗体
PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1) 抗体
AI836256 抗体
mKIAA0606 抗体
PHLPP 抗体
Phlpp 抗体
PLEKHE1 抗体
Plekhe1 抗体
SCOP 抗体
Scop 抗体
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