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Net1 promotes the angiogenesis in cervical squamous cell carcinomas and siRNA targeting of Net1 can effectively reduce angiogenesis and inhibit tumor growth via VEGF signaling.
AMPK (显示 PRKAA1 ELISA试剂盒) phosphorylation of the RHOA (显示 RHOA ELISA试剂盒) guanine nucleotide exchange factor (显示 RASGRF1 ELISA试剂盒) NET1A inhibits extracellular matrix degradation, an early step in cell invasion
Net1 (显示 SLC6A2 ELISA试剂盒) mRNA and protein levels in non-small cell lung cancer tissues were significantly elevated compared with those in their corresponding nontumor tissues.
Simultaneous silencing of NET-1 (显示 SLC6A2 ELISA试剂盒) and survivin (显示 BIRC5 ELISA试剂盒) using one-chain-double-target siRNA thus provides an advantageous alternative in the development of therapeutics for skin squamous cell carcinoma .
These data indicate that Net1A acetylation regulates its subcellular localization to impact on RhoA activity and actin cytoskeletal organization.
NET1 (显示 SLC6A2 ELISA试剂盒) was associated with comorbidity of oppositional defiant disorder and symptoms in Attention-deficit/hyperactivity disorder probands
Net1A plays a plays a previously unrecognized, Rho GTPase (显示 RACGAP1 ELISA试剂盒)-independent role in controlling ATM (显示 ATM ELISA试剂盒) activity and downstream signaling after DNA damage to impact cell survival.
The overexpression of NET-1 (显示 SLC6A2 ELISA试剂盒) in tumor cells may be closely related to the malignant phenotype of skin squamous cell carcinoma including proliferation, invasion and tumor growth.
NET1 (显示 SLC6A2 ELISA试剂盒) expression is elevated in OAC and its pre-malignant phenotype, Barrett's oesophagus. NET1 (显示 SLC6A2 ELISA试剂盒) promotes OAC cell invasion and proliferation.
NET-1 and VEGF silencing play a key role in inhibiting hepatocellular cell proliferation, promoting apoptosis, and reducing angiogenesis.
Data identify for the first time a role for NET1 in vivo and indicate that NET1 expression is essential for the proliferation and differentiation of mammary epithelial cells in the developing mammary gland.
NET1 has roles in stimulating cytoskeletal reorganization and in transforming cells
PAK1 (显示 PAK1 ELISA试剂盒) negatively regulates the activity of NET1
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
neuroepithelial cell transforming gene 1
, neuroepithelial cell-transforming gene 1 protein
, neuroepithelial cell transforming 1
, Rho guanine nucleotide exchange factor (GEF) 8
, guanine nucleotide regulatory protein (oncogene)
, neuroepithelioma transforming gene 1
, p65 Net1 proto-oncogene protein
, small GTP-binding protein regulator
, Net1 homolog
, rho guanine nucleotide exchange factor 8