anti-MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) 抗体产品概述

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anti-MCF.2 Cell Line Derived Transforming Sequence-Like 抗体 (MCF2L)
在www.antibodies-online.cn可供54 MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) 抗体的12不同的供货商。 再加上,我们可以发MCF.2 Cell Line Derived Transforming Sequence-Like 蛋白 (4)MCF.2 Cell Line Derived Transforming Sequence-Like 试剂盒 (3)和数多这个蛋白质的别的产品。 总共64 MCF.2 Cell Line Derived Transforming Sequence-Like产品已列进来了。
别名:
ARHGEF14, C130040G20Rik, Dbs, GP330, mcf 2l, MCF2L, mKIAA0362, NV11503, Ost
列出全部抗体 基因 基因ID UniProt
MCF2L 100361711  
MCF2L 4036 P98164
MCF2L 17207  

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Human MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) interaction partners

  1. we discovered one novel locus (LRP2 (显示 LRP2 抗体); most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).

  2. miR (显示 MLXIP 抗体)-148b directly down-regulates renal megalin (显示 LRP2 抗体) expression.

  3. Exocytosis-mediated urinary C-megalin (显示 LRP2 抗体) excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin (显示 LRP2 抗体)-mediated lysosomal dysfunction in proximal tubules.

  4. The studies suggest that impaired endocytosis of megalin (显示 LRP2 抗体)/cubilin (显示 CUBN 抗体) ligands, hemoglobin (显示 HBB 抗体) and albumin (显示 ALB 抗体), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.

  5. VDR (显示 CYP27B1 抗体) and MEGALIN (显示 LRP2 抗体) gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.

  6. the main role for placental megalin (显示 LRP2 抗体) is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin (显示 LRP2 抗体) in the cytotrophoblasts.

  7. specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2 (显示 LRP2 抗体)/Akt (显示 AKT1 抗体) pathway

  8. abundances of megalin (显示 LRP2 抗体) and Dab2 (显示 DAB2 抗体) (p = 0.046) were reduced in infected placentas from women with LBW deliveries

  9. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (显示 LRP2 抗体) and TSPYL2 (显示 TSPYL2 抗体) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability

  10. A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis.

Mouse (Murine) MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) interaction partners

  1. the PH domain of Dbs has a role in regulating Rho GTPase (显示 RACGAP1 抗体) activation

  2. the PH domain of Dbs has two roles in the regulation of DH domain function, one for GTPase (显示 RACGAP1 抗体) association and activation in vitro and one for phosphoinositide binding and GTPase (显示 RACGAP1 抗体) interaction in vivo, that together promote Dbs association with membranes.

  3. Dbs is activated by Rac1 at the pleckstrin (显示 PLEK 抗体) homology domain

  4. Dbs has the potential to promote proliferation of immature thymocytes, but also sensitizes immature thymocytes to deletion.

  5. Crystal structure of the DH/PH fragment of Dbs without bound GTPase (显示 RACGAP1 抗体)

  6. the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein

  7. Dbs transformation is associated with increased phosphorylation of myosin light chain and stress fiber formation, both of which occur in a ROCK-dependent manner

MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) 抗原简介

Antigen Summary

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Alternative names and synonyms associated with MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L)

  • MCF.2 cell line derived transforming sequence-like (MCF2L) 抗体
  • MCF.2 cell line derived transforming sequence-like (LOC100361711) 抗体
  • MCF.2 cell line derived transforming sequence-like (mcf2l.2) 抗体
  • MCF.2 cell line derived transforming sequence-like (mcf2l) 抗体
  • low density lipoprotein receptor-related protein 2 (LRP2) 抗体
  • MCF.2 cell line derived transforming sequence-like (Mcf2l) 抗体
  • mcf.2 transforming sequence-like (Mcf2l) 抗体
  • ARHGEF14 抗体
  • C130040G20Rik 抗体
  • Dbs 抗体
  • GP330 抗体
  • mcf 2l 抗体
  • MCF2L 抗体
  • mKIAA0362 抗体
  • NV11503 抗体
  • Ost 抗体

Protein level used designations for MCF2L

guanine nucleotide exchange factor DBS , MCF.2 cell line derived transforming sequence-like , coagulation factor VII , guanine nucleotide exchange factor DBS-like , Heymann nephritis antigen homolog , LRP-2 , calcium sensor protein , glycoprotein 330 , low-density lipoprotein receptor-related protein 2 , megalin , DBL's big sister , MCF2 transforming sequence-like protein , MCF2-transforming sequence-like protein , OST oncogene , mcf.2 transforming sequence-like , Ost gamma , exchange factor for RhoA and Cdc42 , guanine nucleotide exchange factor OSTIII

GENE ID SPECIES
418748 Gallus gallus
452678 Pan troglodytes
485555 Canis lupus familiaris
505595 Bos taurus
100122691 Nasonia vitripennis
100361711 Rattus norvegicus
100380200 Xenopus (Silurana) tropicalis
100549760 Meleagris gallopavo
100559055 Anolis carolinensis
100606412 Nomascus leucogenys
4036 Homo sapiens
23263 Homo sapiens
117020 Rattus norvegicus
17207 Mus musculus
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