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Data suggest that MCP1/CCL2 (显示 CCL2 ELISA试剂盒) induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 inhibition suppresses MCP1 (显示 CCL2 ELISA试剂盒)-induced VSMC migration and proliferation. (ARHGEF1 = Rho guanine nucleotide exchange factor 1; RAC1 = Rac (显示 AKT1 ELISA试剂盒) family small GTPase (显示 RACGAP1 ELISA试剂盒) 1; CCL2 (显示 CCL2 ELISA试剂盒) = C-C motif chemokine ligand 2 (显示 CXCL2 ELISA试剂盒))
Data indicate that the crystal structure of PDZ-RhoGEF (显示 ARHGEF11 ELISA试剂盒) PDZ domain (显示 INADL ELISA试剂盒) in complex with the CXC chemokine receptor (显示 CXCR4 ELISA试剂盒) 2 (CXCR2 (显示 CXCR2 ELISA试剂盒)) C-terminal PDZ (显示 INADL ELISA试剂盒) binding motif.
We have reported here for the first time a reduced activity of both Rac1 and Cdc42 (显示 CDC42 ELISA试剂盒) in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1, ARHGEF1, and ARHGAP36 (显示 ARHGAP36 ELISA试剂盒)
contactin-1 (显示 CNTN1 ELISA试剂盒) displayed the ability to phosphorylate the RhoA (显示 RHOA ELISA试剂盒) activator p115 RhoGEF
The novel role for p115RhoGEF in regulation of epithelial plasticity is dependent on Rho-DRF (显示 MPO ELISA试剂盒) signaling module.
Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).
Modification of p115RhoGEF at Serine(330) regulates its RhoGEF (显示 ARHGEF11 ELISA试剂盒) activity.
The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac1 signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex.
High GEF1 expression is associated with metastasis of pancreatic cancer.
Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain.
Arhgef1 controls the process of neurite formation in newborn cortical neurons derived from neural progenitor cells
these findings reveal that Arhgef1 functions as a negative regulator of neurite outgrowth through regulating RhoA-cofilin pathway and actin dynamics.
Upon beta(2)AR activation, both betaArrestin2 and p115RhoGEF translocate to the plasma membrane, with concomitant activation of RhoA (显示 RHOA ELISA试剂盒) and formation of focal adhesions and stress fibers.
Thromboxane receptor (显示 TBXA2R ELISA试剂盒) signaling is required for fibronectin (显示 FN1 ELISA试剂盒)-induced matrix metalloproteinase 9 (显示 MMP9 ELISA试剂盒) production by human and murine macrophages and is attenuated by the Arhgef1 molecule.
Results show that PKC-alpha phosphorylation of p115RhoGEF mediates TNF-alpha signaling to RhoA, and that this plays a critical role in signaling F-actin rearrangement and barrier dysfunction in endothelial cells.
lsc/p115 (显示 ARHGAP4 ELISA试剂盒) deficiency results in impaired neuronal innervation and in motor dysfunction recapitulating several aspects of esophageal achalasia.
These data demonstrate that Arhgef1 regulates alpha5beta1-mediated MMP expression by macrophages and that loss of Arhgef1 by leukocytes leads to pulmonary pathology.
results show that control of RhoA (显示 RHOA ELISA试剂盒) signaling through Arhgef1 is central to the development of angiotensin II-dependent hypertension and identify Arhgef1 as a potential target for the treatment of hypertension
First, Lsc homo-oligomerizes and is negatively regulated through domains in its C terminus; and second, functionally distinct isoforms of Lsc lacking these domains are present in the spleen.
Lsc is essential for mediating TXA(2 (显示 TBXA2R ELISA试剂盒) )signaling involved in apoptosis and actin organization and suggest that TXA(2 (显示 TBXA2R ELISA试剂盒)) regulates thymic cellularity via Lsc.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
rho guanine nucleotide exchange factor (GEF) 1
, Rho guanine nucleotide exchange factor (GEF) 1
, rho guanine nucleotide exchange factor 1-like
, 115 kDa guanine nucleotide exchange factor
, 115-kD protein
, Lsc homolog
, rho guanine nucleotide exchange factor 1
, lbc's second cousin
, lymphoid blast crisis like 2
, lymphoid blast crisis-like 2