anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) 抗体产品概述

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anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like 抗体 (NEDD4L)
在www.antibodies-online.cn可供65 Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) 抗体的16不同的供货商。 再加上,我们可以发Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like 蛋白 (6)和数多这个蛋白质的别的产品。 总共76 Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like产品已列进来了。
别名:
1300012C07Rik, hNEDD4-2, NEDD4, Nedd4-2, NEDD4.2, Nedd4b, RSP5
列出全部抗体 基因 基因ID UniProt
NEDD4L 23327 Q96PU5
NEDD4L 291553  
NEDD4L 83814  

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  1. Human Polyclonal NEDD4L Primary Antibody for EIA, WB - ABIN953641 : Zhou, Kabra, Olson, Piper, Snyder: Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways. in The Journal of biological chemistry 2010 (PubMed)
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  2. Cow (Bovine) Polyclonal NEDD4L Primary Antibody for WB - ABIN2774731 : Raikwar, Thomas: Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. in American journal of physiology. Renal physiology 2008 (PubMed)

更多抗Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like的相互作用对抗体

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. evidence implicating E3 ubiquitin ligase (显示 MUL1 抗体) NEDD4L in the pathogeny of periventricular nodular heterotopia

  2. This study demonstrated that it is possible to downregulate Kv1.3 (显示 KCNA3 抗体) channel density through activation of an E3 ubiquitin ligase (显示 MUL1 抗体) and that inhibition of the protease pathway or mutation of the Nedd4-2 catalytic site prevents Kv1.3 (显示 KCNA3 抗体) modulation.

  3. These findings provide evidence that Nedd4-2 is up-regulated in response to endoplasmic reticulum stress by the spliced form of X-box binding protein 1 (显示 XBP1 抗体) and that this is important in the induction of an appropriate autophagic response.

  4. both Nedd4-1 (显示 NEDD4 抗体) and Nedd4-2 are important regulators for hOAT1 (显示 SLC22A6 抗体) ubiquitination, expression, and function

  5. USP36 (显示 USP36 抗体) actions extend beyond TrkA (显示 NTRK1 抗体) because the presence of USP36 (显示 USP36 抗体) interferes with Nedd4-2-dependent Kv7.2 (显示 KCNQ2 抗体)/3 channel regulation.

  6. NEDD4L negatively regulates PIK3CA (显示 PIK3CA 抗体) protein levels via ubiquitination and is required for the maintenance of PI3K (显示 PIK3CA 抗体)-AKT (显示 AKT1 抗体) signaling pathway.

  7. overexpression of miR (显示 MLXIP 抗体)-93 in lung cancer cells promoted TGF-b-induced EMT (显示 ITK 抗体) through downregulation of NEDD4L. The analysis of publicly available gene expression array datasets indicates that low NEDD4L expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR (显示 MLXIP 抗体)-93 in lung tumorigenesis and metastasis.

  8. the regulation of Nedd4L protein expression may play a role in the development of ovarian cancers.

  9. Propose regulation of placental SNAT2 (显示 SLC38A2 抗体)/LAT1 (显示 LAT 抗体) ubiquitination by mTORC1 and Nedd4-2.

  10. Overexpression of Nedd4-2 enhanced hOAT4 (显示 SLC22A9 抗体) ubiquitination, and inhibited hOAT4 (显示 SLC22A9 抗体) transport activity.

Xenopus laevis Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. these findings suggest that regulation of Dvl (显示 DVL2 抗体) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.

  2. Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (显示 TMPRSS5 抗体)-activated kinase promotes ENaC (显示 SCNN1A 抗体)-Nedd4-2 interaction, inhibiting ENaC (显示 SCNN1A 抗体) by increasing Nedd4-2-dependent ENaC (显示 SCNN1A 抗体) retrieval from the plasma membrane.

  3. results indicate that AMPK (显示 PRKAA2 抗体) inhibits KCNQ1 (显示 KCNQ1 抗体) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.

  4. This study suggested that Nedd4-regulated PTEN (显示 PTEN 抗体) is a key regulator of terminal arborization in vivo.

  5. ENaC-beta (显示 SCNN1B 抗体) regulation that occurs through IKKbeta (显示 IKBKB 抗体)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (显示 SGK1 抗体) and protein kinase A target site.

Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. Tmbim1 (显示 TMBIM1 抗体) promoted the lysosomal degradation of toll-like receptor 4 (显示 TLR4 抗体) by cooperating with the ESCRT endosomal sorting complex to facilitate MVB formation, and the ubiquitination of Tmbim1 (显示 TMBIM1 抗体) by the E3 ubiquitin ligase (显示 MUL1 抗体) Nedd4l was required for this process.

  2. These findings provide evidence that Nedd4-2 is up-regulated in response to endoplasmic reticulum stress by the spliced form of X-box binding protein 1 (显示 XBP1 抗体) and that this is important in the induction of an appropriate autophagic response.

  3. These results identify NKCC1 (显示 SLC12A2 抗体) as a novel target for Nedd4L-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (显示 SCNN1A 抗体)).

  4. Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (显示 NEDD4 抗体)-2 (Nedd4-2)-mediated AMPA (显示 GRIA3 抗体) receptor GluA1 (显示 GRIA1 抗体) ubiquitination.

  5. USP36 (显示 USP36 抗体) actions extend beyond TrkA (显示 NTRK1 抗体) because the presence of USP36 (显示 USP36 抗体) interferes with Nedd4-2-dependent Kv7.2 (显示 KCNQ2 抗体)/3 channel regulation.

  6. These findings elucidate a critical role of Mdm2 (显示 MDM2 抗体)-p53 (显示 TP53 抗体)-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.

  7. We identified glutamate (显示 GRIN1 抗体) receptor subunit 1 (GluA1 (显示 GRIA1 抗体)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2

  8. The short isoform of the ubiquitin ligase (显示 RNF123 抗体) NEDD4L is a CREB (显示 CREB1 抗体) target gene in hepatocytes.

  9. Nedd4-2-mediated ubiquitination of beta-ENaC (显示 SCNN1B 抗体) leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.

  10. The first physiological evidence for an essential function of Nedd4-2 in regulating voltage-gated sodium channels in the central nervous system.

Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) 抗原简介

Antigen Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L)

  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L) 抗体
  • NEDD4L (LOC776799) 抗体
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (nedd4l) 抗体
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (Nedd4l) 抗体
  • neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l) 抗体
  • 1300012C07Rik 抗体
  • hNEDD4-2 抗体
  • NEDD4 抗体
  • Nedd4-2 抗体
  • NEDD4.2 抗体
  • Nedd4b 抗体
  • RSP5 抗体

Protein level used designations for NEDD4L

E3 ubiquitin-protein ligase NEDD4-like , E3 ubiquitin-protein ligase NEDD4-like protein , ubiquitin-protein ligase Rsp5 , neural precursor cell expressed, developmentally down-regulated 4 , NEDD4.2 , neural precursor cell expressed, developmentally down-regulated gene 4b

GENE ID SPECIES
100054395 Equus caballus
100172429 Pongo abelii
776799 Gallus gallus
23327 Homo sapiens
399396 Xenopus laevis
510003 Bos taurus
291553 Rattus norvegicus
100512083 Sus scrofa
476189 Canis lupus familiaris
83814 Mus musculus
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