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Human Polyclonal SGCB Primary Antibody for IHC, IHC (p) - ABIN4284180
Pozsgai, Griffin, Heller, Mendell, Rodino-Klapac: β-Sarcoglycan gene transfer decreases fibrosis and restores force in LGMD2E mice. in Gene therapy 2016
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subcellular localization of dScgbeta dramatically changes during mitosis through possible association with tubulin (显示 TUBB 抗体); these observations point to a complex role of sarcoglycans in non-muscle tissues.
Clinical severity of limb-girdle muscular dystrophy type 2Emay be predicted by SGCB gene mutation and sarcoglycan (显示 SGCD 抗体) protein expression.
Defective assembly of sarcoglycan (显示 SGCD 抗体) complex in patients with beta-sarcoglycan gene mutations
beta-sarcoglycan and SPATA18 (显示 SPATA18 抗体) may have a role in limb-girdle muscular dystrophy type 2E
While the quantity of beta-sarcoglycan was nearly normal (显示 EEF1G 抗体) in the limb girdle muscular dystrophy (LGMD)2E carrier, the levels of dysferlin (显示 DYSF 抗体) protein were reduced to 50% of controls in the carriers of LGMD2B (显示 DYSF 抗体).
These data suggest that formation of the beta-delta-core may promote the export and deposition of sarcoglycan (显示 SGCD 抗体) subcomplexes at the plasma membrane, and therefore identifies a mechanism for sarcoglycan (显示 SGCD 抗体) transport.
The limb-girdle muscular dystrophy patients with beta-sarcoglycan deficient LGMD2E do not enable an accurate prediction of the genotype.
this study shows that the serglycin (显示 SRGN 抗体)-deficient mice are more susceptible to Trichinella spiralis infection and display an unbalanced immune response
beta-Sarcoglycan deficiency reduces atherosclerotic plaque formation in ApoE (显示 APOE 抗体)-knockout mouse model.
Data suggest that serglycin (显示 SRGN 抗体) proteoglycans play a role in extravasation as well as colonization and growth of metastatic cells.
serglycin (显示 SRGN 抗体) deficient mice exhibited elevated concentrations of serum LDL after feeding high-fat diet for 20 weeks.
serglycin (显示 SRGN 抗体) plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin (显示 PRF1 抗体) and granzyme B (显示 Gzmb 抗体), whereas granzyme A (显示 GZMA 抗体) is unaffected
In Sgcb-null mice, severe morphological disruption was present from 4 weeks in both quadriceps and diaphragm, and included conspicuous deposition of extracellular matrix components.
Wild-type mast cells efficiently degraded exogenous or endogenously produced IL-13 (显示 IL13 抗体) upon degranulation,whereas serglycin (显示 SRGN 抗体) -/- mast cells completely lacked this ability.
Dopamine storage increased during mast cell maturation from bone marrow precursors, and was dependent on the presence of serglycin (显示 SRGN 抗体).
Cells lacking mouse mast cell protease 6 (显示 TPSB2 抗体) exhibited similar defects in apoptosis as observed in serglycin (显示 SRGN 抗体)(-/-) cells, indicating that the pro-apoptotic function of serglycin (显示 SRGN 抗体) is due to downstream effects of proteases that are complex-bound to serglycin (显示 SRGN 抗体)
The PRG-1 (显示 PTGR1 抗体) transcription is initiated at multiple transcription start site and no influence on expression in vivo by Nex1 (显示 NEUROD6 抗体) deficiency.
This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.
43 kDa dystrophin-associated glycoprotein
, beta-sarcoglycan(43kD dystrophin-associated glycoprotein)
, limb girdle muscular dystrophy 2E (non-linked families)
, sarcoglycan, beta (43kD dystrophin-associated glycoprotein)
, sarcoglycan beta
, SarcoGlycaN family member (sgn-1)