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demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 (显示 GRK5 蛋白) and GRK6, both of which regulate Src (显示 SRC 蛋白) and IGF-IR signaling and have been implicated in cancer.
Genetic variation in OXTR (显示 OXTR 蛋白) and GRK6 is associated with the amount of oxytocin required as well as the duration of labor and risk for cesarean delivery among women undergoing induction of labor near term.
This work demonstrates the importance of GRK6 in regulation of hematopoietic stem cell self-renewal and reveals its potential role in participation of stress response.
Decreased expression of GRK6 may serve as an independent predictor of overall survival in lung adenocarcinoma.
The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene.
Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese
these results indicate that GRK6 complexes with AGS3 (显示 GPSM1 蛋白)-Galphai2 (显示 GNAI2 蛋白) to regulate CXCR2 (显示 CXCR2 蛋白)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.
GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4.
results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma
Downregulation of GRK6 expression enhances CXCR4 (显示 CXCR4 蛋白) signaling and promoted medulloblastoma cell migration.
GRK6-mediated OXTR (显示 OXTR 蛋白) desensitization in labor is necessary for normal uterine contractile patterns and optimal fetal outcome.
GRK6 directly phosphorylates Nfkbia (显示 NFKBIA 蛋白) at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha (显示 TNF 蛋白)-induced NF-kappaappaB signaling.
data demonstrate that GRK6 plays a feedback regulatory role in CXCR2 (显示 CXCR2 蛋白)-mediated tumor development, invasion and metastasis
G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance.
Chemokine receptor CXCR2 (显示 CXCR2 蛋白) interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis.
Results identify GRK5 (显示 GRK5 蛋白)/6 as novel kinases for the single transmembrane receptor LRP6 (显示 LRP6 蛋白) during Wnt (显示 WNT2 蛋白) signaling.
Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity.
In the absence of GRK6, the G-CSF (显示 CSF3 蛋白)-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF (显示 CSF3 蛋白), significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
G protein-coupled receptor kinase 6
, G protein-coupled receptor kinase 6-like
, g protein-coupled receptor kinase GRK6
, G-protein coupled receptor kinase 6