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Gbetagamma signaling controls the polarization of zebrafish primordial germ cells by regulating Rac (显示 AKT1 ELISA试剂盒) activity.
We show that targeted knockdown of the G protein gng2 gene (Ggamma2) blocks the normal angiogenic process in developing zebrafish embryos. Moreover, loss of gng2 function inhibits the ability of VEGF to promote the angiogenic sprouting of blood vessels.
High GNG2 expression is associated with alcoholic hepatitis.
G-protein betagamma subunits are positive regulators of Kv7.4 (显示 KCNQ4 ELISA试剂盒) and native vascular Kv7 channel activity.
Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Data indicate that endogenous mTOR (显示 FRAP1 ELISA试剂盒) interacts with Gbetagamma.
increased protein expression level of GNG2 alone inhibits proliferation of malignant melanoma cells in vitro and in vivo
presence of Gng2 and Netrin-G2 immunoreactive elements in the insular cortex, but not in the putamen, suggests a possible common ontogeny of the claustrum and insula
Gbetagamma inhibits Epac (显示 RAPGEF3 ELISA试剂盒)-induced Ca 2 (显示 CA2 ELISA试剂盒)+ elevation in melanoma cells. Cross talk of Ca 2 (显示 CA2 ELISA试剂盒)+ signaling between Gbetagamma & Epac (显示 RAPGEF3 ELISA试剂盒) plays a major role in melanoma cell migration.
Data implicate the domain I-II linker region as an important contributor to voltage dependent Gbeta1/Ggamma2 modulation of Cav2.2 (显示 CACNA1B ELISA试剂盒) calcium channels.
Data show that activation of PLCbeta(2) by alpha(q) and beta1gamma2 differ from activation by Rac2 (显示 RAC2 ELISA试剂盒) and from each other.
Data show that G protein inhibition of N-type calcium channels is critically dependent on two separate but adjacent approximately 20-amino acid regions of the Gbeta (显示 SUCLG2 ELISA试剂盒) subunit, as examined with Gbetas 1 and 5 and Ggamma2.
determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits
It was concluded that GIRK2 (显示 KCNJ6 ELISA试剂盒), through its dual responsiveness to G protein beta (显示 GNB3 ELISA试剂盒)-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity.
signaling pathway by which G(i)-coupled receptor specifically induces Rac (显示 AKT1 ELISA试剂盒) and Cdc42 (显示 CDC42 ELISA试剂盒) activation through direct interaction of Gbetagamma with FLJ00018.
This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules.
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
, guanine nucleotide-binding protein gamma 2
, g gamma-I
, guanine nucleotide binding protein gamma 2
, guanine nucleotide-binding protein G(I)/G(O) gamma-2 subunit
, guanine nucleotide binding protein (G protein), gamma 2 subunit