Use your antibodies-online credentials, if available.
individuals with loss-of-function GNB5 alleles had more severe symptoms, including substantial developmental delay, speech defects, severe hypotonia, pathological gastro-esophageal reflux, retinal disease, and sinus-node dysfunction, whereas related heterozygotes harboring missense variants presented with a clinically milder phenotype
Results suggest that D2R (显示 DRD2 ELISA试剂盒) can interact with and stabilize the Gb5 protein, independently of R7 G protein signaling (RGS (显示 PITX2 ELISA试剂盒)) proteins.
The intrinsic resistance to TRAIL-triggered apoptosis of colon cancer cells is overcome by antagonization of Gbeta5.
Type 5 G protein beta subunit (显示 GNB3 ELISA试剂盒) (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9 (显示 RGS ELISA试剂盒)) with membrane anchors
Gbeta5's function in vision is reviewed.
under certain conditions, RGS9 (显示 RGS ELISA试剂盒) and Gbeta5 may possibly function as betagamma dimer
From yeast two hybrid screening with HBX as bait, human guanine nucleotide binding protein beta subunit 5L (GNbeta5) was isolated from the cDNA library constructed in this study as a new hepatitis b X protein-interacting protein.
cytoplasmic RGS7 (显示 RGS7 ELISA试剂盒)*Gbeta5*R7BP (显示 RGS7BP ELISA试剂盒) heterotrimers and RGS7 (显示 RGS7 ELISA试剂盒)*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor (显示 ADRA1A ELISA试剂盒) signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP (显示 RGS7BP ELISA试剂盒).
G-protein beta5 short splice variant isoform is indispensable for outer plexiform layer integrity and normal light responses of the retina in transgenic mice.
cytosolic chaperonin (显示 HSPD1 ELISA试剂盒) complex-dependent mechanism exists for Gbeta5-RGS7 (显示 RGS7 ELISA试剂盒) assembly that utilizes the co-chaperone activity of PhLP1 in a unique way.
The complex of G protein regulator RGS9-2 (显示 RGS ELISA试剂盒) and Gbeta (显示 SUCLG2 ELISA试剂盒)(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum.
Expression of the Gbeta5/R7-RGS (显示 PITX2 ELISA试剂盒) protein complex in pituitary and pancreatic islet cells.
Gbeta5/RGS6 (显示 RGS6 ELISA试剂盒) (guanine nucleotide binding protein (显示 TRIM23 ELISA试剂盒) beta5/regulator of G-protein signaling 6 (显示 RGS6 ELISA试剂盒)) complex modulates timing of parasympathetic influence on atrial myocytes and heart rate.
Elimination of Gbeta5-RGS (显示 PITX2 ELISA试剂盒) complexes led to a striking level of hyperactivity that far exceeds activity levels previously observed in animal models.
We conclude that even a partial reduction in Gbeta5-R7 level can perturb normal animal metabolism and behavior.
Gbeta5 regulates dendritic arborization and/or synapse formation during development, in part by effects on gene expression; mice lacking Gbeta5 have a markedly abnormal neurologic phenotype.
regulator of G-protein signalling 7 binding protein (显示 RGS7BP ELISA试剂盒) contributes significantly to the nuclear localization of endogenous G beta(5)/R7-RGS (显示 PITX2 ELISA试剂盒) complex in brain
study found that RGS7-Gbeta5 complexes bound to G protein-gated potassium channels and facilitated their functional coupling to GABA(B) receptors in neurons
Disruption of the Gbeta5 gene in mice abolishes expression of Gbeta5-L in the retina and also greatly reduces the expression level of RGS9-1, indicating a complex containing RGS9-1-Gbeta5-L is essential for normal G-protein deactivation and rod function
photoreceptors R9AP (显示 RGS9BP ELISA试剂盒) determines the stability of the RGS9 (显示 RGS ELISA试剂盒).Gbeta5 complex, and therefore all three proteins, RGS9 (显示 RGS ELISA试剂盒), Gbeta5 , and R9AP (显示 RGS9BP ELISA试剂盒), are obligate members of the regulatory complex that speeds the rate at which transducin (显示 GNAT1 ELISA试剂盒) hydrolyzes GTP (显示 AK3 ELISA试剂盒).
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist.
G protein, beta subunit 5L
, G protein, beta-5 subunit
, guanine nucleotide-binding protein subunit beta-5
, guanine nucleotide-binding protein, beta subunit 5L
, transducin beta chain 5
, guanine nucleotide binding protein, beta 5
, guanine nucleotide binding protein (G protein), beta polypeptide 5
, guanine nucleotide-binding protein, beta-5 subunit
, guanine nucleotide binding protein beta 5