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In thyroid hemiagenesis, genomic examinations revealed the presence of four recurrent defects (three deletions and one duplication) affecting highly conservative proteasome genes PSMA1 (显示 PSMA1 ELISA试剂盒), PSMA3 (显示 PSMA3 ELISA试剂盒), and PSMD3.
this study shows that haplotypes consisting of single nucleotide polymorphisms harboring PSMD3, CSF3 (显示 CSF3 ELISA试剂盒) and MED24 (显示 MED22 ELISA试剂盒) genes are associated with asthma in Slovenian patients
A strong association between genetic variant rs2305482 in PSMD3 on chromosome 17 and IFN-induced neutropenia.
HNF1A (显示 HNF1A ELISA试剂盒) gene was associated with C-reactive protein (显示 CRP ELISA试剂盒), and the region including PSMD3 and CSF3 (显示 CSF3 ELISA试剂盒) genes was associated with white blood cell count.
Our study suggests that PSMD3 variants are associated with insulin (显示 INS ELISA试剂盒) resistance in populations of different ancestries and that these relationships may also be modified by dietary factors.
Study identified significantly white blood cell count (WBC) level associated SNPs of three separate genes GSDMA, MED24 (显示 MED22 ELISA试剂盒), and PSMD3 in European continent (EA) subjects.
The significant contribution of PSMD3-CSF3 (显示 CSF3 ELISA试剂盒) and PLCB4 (显示 PLCb4 ELISA试剂盒) loci to the regulation of neutrophil count, is demonstrated.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count.
26S proteasome non-ATPase regulatory subunit 3
, 26S proteasome regulatory subunit RPN3
, 26S proteasome regulatory subunit S3
, proteasome subunit p58
, tissue specific transplantation antigen 2
, tissue specific transplantation antigen P91A
, transplantation antigen P91A
, tum-P91A antigen
, proteasome 26S non-ATPase subunit 3