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Human Monoclonal PSMA7 Primary Antibody for IF, IHC (p) - ABIN562474
Smith, Qutob, Watson, Beavis, Potts, Welham, Garimella, Lind, Drew, Cawkwell: Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome? in Neoplasia (New York, N.Y.) 2009
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Expression of proteasomal subunit PSMA7 results in potent inhibition of retinoic acid induced gene-1 (RIG)-1 (显示 ROBO3 抗体) and MAVS (显示 MAVS 抗体)-mediated interferon-beta (显示 IFNB1 抗体) promoter activity.
Data indicate that proteasome subunit alpha 6 (PSMA6 (显示 PSMA6 抗体)) direct contacts with proteasome subunit alpha 7 (PSMA7) tetradecamer.
Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit (显示 PSMD14 抗体) 9 (显示 ATP5G1 抗体) (PSMD9 (显示 PSMD9 抗体)), proteasome alpha type 7 subunit (PSMA7) and PSMD13 (显示 PSMD13 抗体) genes.
c-Abl (显示 ABL1 抗体) regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit
PSMA7 functions partially through downregulation NOD1 (显示 NOD1 抗体).
PSMA7 inhibits the proliferation, tumorigenicity and invasion of A549 cells in vitro
CNB (显示 PPP3R1 抗体) binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha (显示 HIF1A 抗体)) via the proteasome pathway.
High expression of PSMA7 was significantly correlated with liver metastasis.
The present study demonstrates that c-Abl (显示 ABL1 抗体) and Arg (abl (显示 ABL1 抗体)-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr (显示 TYR 抗体)-153.
PSMA7 may play an important role in colorectal cancer progression.
cell surface binding of EMAP-II results in its internalization into the cytoplasmic compartment where it interacts with PSMA7, a component of the proteasome degradation pathway. This interaction increases HIF-1alpha (显示 HIF1A 抗体) degradation under hypoxic conditions.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9.
proteasome subunit alpha type 7
, proteasome alpha 7 subunit
, proteasome alpha subunit type 7
, proteasome subunit alpha type-7-like
, proteasome subunit RC6-1
, proteasome subunit alpha type-7
, proteasome subunit XAPC7
, proteasome subunit alpha 4
, proteasome 28 kDa subunit homolog