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PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells
Myt1 (显示 MYT1 ELISA试剂盒) is inactivated by MEK1 (显示 MAP2K1 ELISA试剂盒) mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis.
MYT1 (显示 MYT1 ELISA试剂盒) binds to TSAP6 (显示 STEAP3 ELISA试剂盒) in tumor cells and has a role in cell cycle regulation
Myt1 (显示 MYT1 ELISA试剂盒) is phosphorylated by polo-like kinase 1 (显示 PLK1 ELISA试剂盒)
the induction of Cdc2 (显示 CDK1 ELISA试剂盒) phosphorylation due to the increase of Wee1 (显示 WEE1 ELISA试剂盒) and Myt1 (显示 MYT1 ELISA试剂盒) as well as the reduction of Cdc2 (显示 CDK1 ELISA试剂盒) and cyclin B1 (显示 CCNB1 ELISA试剂盒) are involved in 1,25[OH]2VD3-induced G2/M arrest of keratinocytes.
The results show that Myt1 (显示 MYT1 ELISA试剂盒)-mediated suppression of Cdc2 (显示 CDK1 ELISA试剂盒) activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis in Hela cells.
Data show that CDK1 (显示 CDK1 ELISA试剂盒) and cyclin B synergize during oocyte maturation to inhibit Myt1 ensuring meiotic progression.
Study propose a model in which the appearance of active MPF (显示 MSLN ELISA试剂盒) complexes following increased Cyclin B synthesis causes Myt1 inhibition, upstream of the MPF (显示 MSLN ELISA试剂盒)/Cdc25 (显示 CDC25C ELISA试剂盒) amplification loop.
Autophosphorylation of Myt1 is a novel inhibitory mechanism that adds another layer of complexity to the phosphorylation-dependent mechanism of Myt1 regulation.
XRINGO-activated CDKs can phosphorylate specific residues in the regulatory domain of Myt1.
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
, protein kinase Myt1
, protein kinase, membrane associated tyrosine/threonine 1
, membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase-like
, myt1 kinase
, MYT1 kinase
, membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase