Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) ELISA试剂盒产品概述

Full name:
Origin Recognition Complex, Subunit 1-Like (Yeast) ELISA试剂盒 (ORC1L)
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别名:
AA545195, CG10667, Dmel\\CG10667, DmOrc1, DmOrc1p, dORC1, HSORC1, MmORC1, ORC, orc1, Orc1l, PARC1, rDmORC, xorc1
list all ELISA KIts 基因 基因ID UniProt
 ORC1L ORC1L 4998 Q13415
小鼠 ORC1L ORC1L 18392 Q9Z1N2
大鼠 ORC1L ORC1L 313479 Q80Z32

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适于 Origin Recognition Complex, Subunit 1-Like (Yeast) 相互作用对的更多 ELISA 试剂盒

Fruit Fly (Drosophila melanogaster) Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. analyses show that orc1 allele newly identified is female sterile and possesses a unique feature of phenotypes that are distinct in different modes of DNA replication

  2. Orc1 functioned in silencing before duplication and Orc1 and Sir2 (显示 SIRT1 ELISA试剂盒) may have an ancient history of cooperating to generate chromatin structures, with Sir2 (显示 SIRT1 ELISA试剂盒) deacetylating histones and Orc1 binding to these deacetylated nucleosomes

Human Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. Orc1 acts as a nucleating center for origin recognition complex assembly and then pre-replication complex assembly by binding to mitotic chromosomes, followed by gradual removal from chromatin during the G1 phase.

  2. ORC1 harbors a G-rich RNA/ssDNA-binding domain, which may be involved in the preferential binding to G-quadruplex-formable RNA/DNA by ORC. Structure modeling predicts the structural similarity between the G-rich RNA/ssDNA-binding domain of ORC1 and part of mammalian DNA methyltransferase 1 (显示 DNMT1 ELISA试剂盒).

  3. ORC1 associated with transcription start sites of coding or noncoding RNAs. Transcription levels at the ORC1 sites directly correlated with replication timing.

  4. results identify the BAH (显示 ASPH ELISA试剂盒) domain as a novel methyl-lysine-binding module, thereby establishing the first direct link between histone methylation and the metazoan DNA replication machinery, and defining a pivotal aetiological role for the canonical H4K20me2 mark, via ORC1, in primordial dwarfism

  5. Orc1 harbors a PACT (显示 RBBP6 ELISA试剂盒) centrosome-targeting domain and a separate domain that differentially inhibits the protein kinase (显示 CDK7 ELISA试剂盒) activities of Cyclin E (显示 CCNE1 ELISA试剂盒)-CDK2 (显示 CDK2 ELISA试剂盒) and Cyclin A (显示 CCNA2 ELISA试剂盒)-CDK2 (显示 CDK2 ELISA试剂盒)

  6. Data show that purified Epstein-Barr nuclear antigen 1 EBNA1 recruits purified Human Orc1 and Cdc6 (显示 CDC6 ELISA试剂盒) onto replication origin oriP.

  7. A lethal phenotype was seen in four individuals with compound heterozygous ORC1 mutations

  8. As cells moved through the cell cycle, the local-ization of ORC1 shifted, suggesting changes in thelocalization of ORC-bound origin sequences.

  9. Mutations in ORC1, encoding a subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. These mutations disrupt ORC1 functions including pre-replicative complex formation and origin activation.

  10. Data show that Orc1 specifically binds hypo-phosphorylated Rb and that this interaction is competitive with the binding of Rb to E2F1 (显示 E2F1 ELISA试剂盒).

Mouse (Murine) Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. mouse Orc1, Orc2, and Orc3 (显示 ORC3 ELISA试剂盒) each exist in two alternative-splicing variants and naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation

Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) 抗原简介

Antigen Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L)

  • Origin recognition complex subunit 1 (Orc1) Elisa Kit
  • origin recognition complex subunit 1 (LOC100689425) Elisa Kit
  • origin recognition complex, subunit 1 (ORC1) Elisa Kit
  • origin recognition complex, subunit 1 (orc1) Elisa Kit
  • origin recognition complex, subunit 1 (Orc1) Elisa Kit
  • AA545195 Elisa Kit
  • CG10667 Elisa Kit
  • Dmel\\CG10667 Elisa Kit
  • DmOrc1 Elisa Kit
  • DmOrc1p Elisa Kit
  • dORC1 Elisa Kit
  • HSORC1 Elisa Kit
  • MmORC1 Elisa Kit
  • ORC Elisa Kit
  • orc1 Elisa Kit
  • Orc1l Elisa Kit
  • PARC1 Elisa Kit
  • rDmORC Elisa Kit
  • xorc1 Elisa Kit

Protein level used designations for ORC1L

CG10667-PA , Orc1-PA , origin recognition complex 1 , origin recognition complex subunit 1 , origin recognition complex, subunit 1 homolog , replication control protein 1 , origin recognition complex protein 1 , origin recognition complex, subunit 1-like

GENE ID SPECIES
35686 Drosophila melanogaster
100689425 Cricetulus griseus
4998 Homo sapiens
398063 Xenopus laevis
513523 Bos taurus
18392 Mus musculus
313479 Rattus norvegicus
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