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anti-DYRK1A (DYRK1A) 抗体产品概述

Full name:
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A 抗体 (DYRK1A)
在www.antibodies-online.cn可供131 Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) 抗体的19不同的供货商。 再加上,我们可以发DYRK1A 试剂盒 (8)DYRK1A 蛋白 (7)和数多这个蛋白质的别的产品。 总共158 DYRK1A产品已列进来了。
别名:
2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, DYRK1, DYRK1A, ENSMUSG00000074897, Gm10783, HP86, mmb, MNB, Mnbh, Mp86, MRD7, PSK47

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引用最多的anti-DYRK1A 抗体

  1. Human Monoclonal DYRK1A Primary Antibody for ELISA, WB - ABIN560675 : Aranda, Alvarez, Turró, Laguna, de la Luna: Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. in Molecular and cellular biology 2008 (PubMed)
    Show all 38 references for ABIN560675

  2. Human Polyclonal DYRK1A Primary Antibody for WB - ABIN1881275 : Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 4 references for ABIN1881275

  3. Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN359711 : Adayev, Chen-Hwang, Murakami, Lee, Bolton, Hwang: Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro. in Biochemistry 2007 (PubMed)
    Show all 4 references for ABIN359711

  4. Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN359712 : Chang, Lin, Yang, Yen, Lai, Chen, Liang, Yu: Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis. in International journal of cancer. Journal international du cancer 2007 (PubMed)
    Show all 4 references for ABIN359712

  5. Human Polyclonal DYRK1A Primary Antibody for EIA, WB - ABIN783434 : Park, Oh, Chung: Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. in BMB reports 2009 (PubMed)

更多抗DYRK1A的相互作用对抗体

Human Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Identify Dyrk1a as a novel negative regulator of D-cyclin (显示 PCNA 抗体)-mediated Rb1 (显示 RB1 抗体)/E2f (显示 E2F1 抗体)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.

  2. The deleterious effect of DYRK1A triplication in the formation of the cerebral cortex begins at the onset of neurogenesis, which is relevant to the search for early therapeutic interventions in Down syndrome.

  3. mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models

  4. Cyclin D1 (显示 CCND1 抗体) Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome.

  5. data indicate that host factor DYRK1A plays a role in the regulation of viral transcription and latency.

  6. Inhibition of DYRK1A and GSK3B (显示 GSK3b 抗体) induces human beta-cell proliferation

  7. A de novo splice site mutation and a de novo nonsense mutation in DYRK1A were identified in two patients with syndromic intellectual disability.

  8. RNA-seq evidence of biallelic expression of DYRK1A and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of DYRK1A is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (显示 WRB 抗体) differentially methylated region (DMR (显示 WDR20 抗体)) in disomic controls or trisomy (Down syndrome) individuals.

  9. Our report represents the largest cohort of individuals with DYRK1A disruptions to date, and is the first attempt to define consistent genotype-phenotype correlations among subjects with 21q22.13 microdeletions and DYRK1A SNVs or small INDELs.

  10. We identified unique truncating and non-synonymous mutations (three nonsense, four frameshift and two missense) in DYRK1A in nine patients and a large chromosomal deletion that encompassed DYRK1A in one patient

Mouse (Murine) Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Identify Dyrk1a as a novel negative regulator of D-cyclin (显示 PCNA 抗体)-mediated Rb1 (显示 RB1 抗体)/E2f (显示 E2F1 抗体)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.

  2. study identifies DYRK1A-STAT (显示 STAT1 抗体) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome

  3. This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.

  4. Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.

  5. the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.

  6. Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis.

  7. these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos.

  8. Show the crucial role of the DYRK1A pathway in the regulation of beta cell mass and carbohydrate metabolism in vivo. Activating the DYRK1A pathway could thus represent an innovative way to increase functional beta cell mass.

  9. DYRK1A has a role in lymphopoiesis; Cyclin D3 (显示 CCND3 抗体) protein stability is negatively regulated during exit from the proliferative phases of B and T cell development

  10. Dyrk1A has a role in phosphorylation and inactivation of GSK3beta (显示 GSK3b 抗体)

Xenopus laevis Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Dyrk1A positively and selectively modulates p120-catenin (显示 CTNND1 抗体) protein levels, thus having an impact on p120-catenin (显示 CTNND1 抗体) and Kaiso (显示 ZBTB33 抗体) (and canonical Wnt (显示 WNT2 抗体)) gene targets such as siamois and wnt11.

DYRK1A 抗原简介

Antigen Summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Alternative names and synonyms associated with DYRK1A

  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) 抗体
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (dyrk1a) 抗体
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a) 抗体
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1a) 抗体
  • 2310043O08Rik 抗体
  • D16Ertd272e 抗体
  • D16Ertd493e 抗体
  • Dyrk 抗体
  • DYRK1 抗体
  • DYRK1A 抗体
  • ENSMUSG00000074897 抗体
  • Gm10783 抗体
  • HP86 抗体
  • mmb 抗体
  • MNB 抗体
  • Mnbh 抗体
  • Mp86 抗体
  • MRD7 抗体
  • PSK47 抗体

Protein level used designations for DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A , dual specificity tyrosine-phosphorylation-regulated kinase 1A , minibrain , protein kinase minibrain homolog , dual specificity tyrosine-phosphorylation-regulated kinase 1A-like , MNB/DYRK protein kinase , dual specificity YAK1-related kinase , hMNB , mnb protein kinase homolog hp86 , serine/threonine kinase MNB , serine/threonine-specific protein kinase , Dual Specificity Yak1-related kinase , MNBH , RP86 , minibrain protein kinase , Protein kinase minibrain homolog

GENE ID SPECIES
100051707 Equus caballus
458545 Pan troglodytes
693812 Macaca mulatta
779733 Xenopus (Silurana) tropicalis
100019775 Monodelphis domestica
100078677 Ornithorhynchus anatinus
100389032 Callithrix jacchus
100479774 Ailuropoda melanoleuca
100562279 Anolis carolinensis
100601498 Nomascus leucogenys
1859 Homo sapiens
13548 Mus musculus
25255 Rattus norvegicus
100350296 Oryctolagus cuniculus
395233 Gallus gallus
100514684 Sus scrofa
446302 Xenopus laevis
487755 Canis lupus familiaris
532989 Bos taurus
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