Stathmin 1 蛋白 (STMN1)产品概述

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Stathmin 1 蛋白 (STMN1)
在www.antibodies-online.cn可供28 Stathmin 1 (STMN1) 蛋白的15不同的供货商。 再加上,我们可以发Stathmin 1 抗体 (357)Stathmin 1 试剂盒 (42)和数多这个蛋白质的别的产品。 总共446 Stathmin 1产品已列进来了。
别名:
19k, C1orf215, cb959, fj43c10, Lag, Lap18, LOC100217988, Op18, P18, P19, Pig, Pp17, Pp18, Pp19, Pr22, prosolin, Smn, stathmin, stmn1, stmn1a, wu:fb14e04, wu:fj38b07, wu:fj43c10, zgc:110159, zgc:136942
列出全部蛋白 基因 基因ID UniProt
STMN1 3925 P16949
STMN1 16765 P54227
STMN1 29332 P13668

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引用最多的Stathmin 1 蛋白

  1. Human Stathmin 1 Protein expressed in Escherichia coli (E. coli) - ABIN667094 : Maucuer, Doye, Sobel: A single amino acid difference distinguishes the human and the rat sequences of stathmin, a ubiquitous intracellular phosphoprotein associated with cell regulations. in FEBS letters 1990 (PubMed)
    Show all 3 references for 667094

  2. Human Stathmin 1 Protein expressed in Escherichia coli (E. coli) - ABIN2181791 : Redeker, Lachkar, Siavoshian, Charbaut, Rossier, Sobel, Curmi: Probing the native structure of stathmin and its interaction domains with tubulin. Combined use of limited proteolysis, size exclusion chromatography, and mass spectrometry. in The Journal of biological chemistry 2000 (PubMed)

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Human Stathmin 1 (STMN1) interaction partners

  1. Our finding demonstrates that RSK2 (显示 RPS6KA3 蛋白) directly phosphorylates stathmin and regulates microtubule polymerization to provide a pro-invasive and pro-metastatic advantage to cancer cells. Therefore, the RSK2 (显示 RPS6KA3 蛋白)-stathmin pathway represents a promising therapeutic target and a prognostic marker for metastatic human cancers.

  2. stathmin expression was significantly associated with shorter progression-free survival and overall survival for all analyzed cases of endometrial cancer; findings demonstrate that high stathmin expression is a poor prognostic marker in endometrial cancer

  3. Integrin beta1 appears to serve as a partner of Stathmin induction of ERK (显示 EPHB2 蛋白) and Akt (显示 AKT1 蛋白) signaling by inhibiting apoptosis in the cholangiocarcinoma cell.

  4. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in gastric cancer (GC) and could be a novel therapeutic target in metastatic GC.

  5. STMN1,COF1 (显示 CFL1 蛋白) and PAIRBP1 (显示 SERBP1 蛋白) thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 (显示 THBS2 蛋白) and POSTN (显示 POSTN 蛋白) were connected to low grade tumors with better prognosis

  6. The phosphorylation-specific association of STMN1 with GRP78 (显示 HSPA5 蛋白) promotes breast cancer metastasis.

  7. hese results suggested that STMN1 plays an important role in proliferation and migration of hypopharyngeal squamous cell carcinoma and may be used as a potential prognostic biomarker or therapeutic target of hypopharyngeal squamous cell carcinoma (HSCC) .

  8. High STMN1 expression is associated with invasion in endometrial carcinoma.

  9. High expression of stathmin 1 predicts poor outcome in oral squamous cell carcinoma patients treated by docetaxel-containing regimens.

  10. The expressions of TYMS (显示 TYMS 蛋白), TUBB3 (显示 TUBB3 蛋白) and STMN1 were significantly associated with the clinicopathological characteristics of age, gender and family history of gastric cancer, but not with differentiation, growth patterns, metastasis and TNM (显示 ODZ1 蛋白) staging in patients with gastric cancer.

Mouse (Murine) Stathmin 1 (STMN1) interaction partners

  1. EGFR (显示 EGFR 蛋白) suppression of mitotic regulators including Rcc2 (显示 RCC2 蛋白) and Stathmin 1 are a mechanism for catagen induction in mouse skin

  2. We identified stathmin as a key molecule aiding in septin (显示 SEPT6 蛋白)-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7 (显示 SEPT7 蛋白)-null fibroblasts

  3. Overexpressing stathmin reduces complement receptor 3 (显示 ITGAM 蛋白)-mediated phagocytosis and cellular activation, implicating a pivotal inhibitory role for stathmin in classically activated macrophages.

  4. Stathmin cooperates with p27(kip1 (显示 CDKN1B 蛋白)) to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression.

  5. The protein profiles during murine embryo implantation were clarified. Stathmin 1 might be a potential regulator of embryo implantation.

  6. Results show an important role for stathmin during adult neurogenesis in the subgranular zone of the mouse hippocampus; propose that stathmin controls the transition from neuronal precursors to early postmitotic neurons

  7. Stathmin mutations disrupt changes in microtubule stability, GluA2 (显示 GRIA2 蛋白) localization, synaptic plasticity and memory.

  8. Stmn deletion does not prolong the lifespan of spinal muscular atrophy-like mice, suggesting that stathmin dysregulation and microtubule disruption are not a cause but rather a consequence of SMA (显示 SMN1 蛋白) pathology.

  9. stathmin expression is dispensable for tumor onset, at least in mice, thus making stathmin a virtually exclusive marker of aggressive disease and a promising therapeutic target for advanced cancers.

  10. results demonstrate the mechanism of stathmin-dependent control of MT dynamics, Rho signaling, and permeability

蛋白简介Stathmin 1 (STMN1)

蛋白简介

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Stathmin 1 (STMN1)

  • stathmin 1 (stmn1-a)
  • stathmin 1 (STMN1)
  • stathmin 1 (stmn1)
  • stathmin 1b (stmn1b)
  • stathmin 1a (stmn1a)
  • stathmin 1/oncoprotein 18 (LOC100217988)
  • stathmin 1/oncoprotein 18 (LOC100229194)
  • stathmin (stmn1)
  • stathmin 1 (Stmn1)
  • 19k 蛋白
  • C1orf215 蛋白
  • cb959 蛋白
  • fj43c10 蛋白
  • Lag 蛋白
  • Lap18 蛋白
  • LOC100217988 蛋白
  • Op18 蛋白
  • P18 蛋白
  • P19 蛋白
  • Pig 蛋白
  • Pp17 蛋白
  • Pp18 蛋白
  • Pp19 蛋白
  • Pr22 蛋白
  • prosolin 蛋白
  • Smn 蛋白
  • stathmin 蛋白
  • stmn1 蛋白
  • stmn1a 蛋白
  • wu:fb14e04 蛋白
  • wu:fj38b07 蛋白
  • wu:fj43c10 蛋白
  • zgc:110159 蛋白
  • zgc:136942 蛋白

Protein level used designations for Stathmin 1 蛋白 (STMN1)

oncoprotein 18 , stathmin 1 a , stathmin 1/oncoprotein 18 , fj38b07 , stathmin 1/oncoprotein 18b , stathmin 1 , stathmin , leukemia-associated phosphoprotein p18 , metablastin , phosphoprotein 19 , phosphoprotein p19 , prosolin , transmembrane protein C1orf215 , leukemia associated phosphoprotein p18 , leukemia-associated gene protein , leukemia-associated cytosolic phosphoprotein stathmin , stathmin-1

GENE ID SPECIES
380364 Xenopus laevis
456650 Pan troglodytes
493340 Xenopus (Silurana) tropicalis
550548 Danio rerio
678630 Danio rerio
100217988 Taeniopygia guttata
100229194 Taeniopygia guttata
100528882 Ictalurus punctatus
3925 Homo sapiens
16765 Mus musculus
29332 Rattus norvegicus
100732759 Cavia porcellus
396057 Gallus gallus
494463 Sus scrofa
616317 Bos taurus
478175 Canis lupus familiaris
101113917 Ovis aries
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