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overexpression correlates with poorer prognosis and interacts with p53 (显示 TP53 蛋白) in oral squamous cell carcinoma
study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
STMN1 gene and miRNA-223 expression profiles in non-tumor liver tissues were predictive of the risk for multicentric hepatocellular carcinoma recurrence.
The crucial role of FOXM1 (显示 FOXM1 蛋白) and STMN1 in TKI-induced enrichment of CSC and drug resistance was demonstrated by knockdown of STMN1 and FOXM1 (显示 FOXM1 蛋白) in NSCLC cells.
Our finding demonstrates that RSK2 (显示 RPS6KA3 蛋白) directly phosphorylates stathmin and regulates microtubule polymerization to provide a pro-invasive and pro-metastatic advantage to cancer cells. Therefore, the RSK2 (显示 RPS6KA3 蛋白)-stathmin pathway represents a promising therapeutic target and a prognostic marker for metastatic human cancers.
stathmin expression was significantly associated with shorter progression-free survival and overall survival for all analyzed cases of endometrial cancer; findings demonstrate that high stathmin expression is a poor prognostic marker in endometrial cancer
Integrin beta1 appears to serve as a partner of Stathmin induction of ERK (显示 EPHB2 蛋白) and Akt (显示 AKT1 蛋白) signaling by inhibiting apoptosis in the cholangiocarcinoma cell.
STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in gastric cancer (GC) and could be a novel therapeutic target in metastatic GC.
STMN1,COF1 (显示 CFL1 蛋白) and PAIRBP1 (显示 SERBP1 蛋白) thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 (显示 THBS2 蛋白) and POSTN (显示 POSTN 蛋白) were connected to low grade tumors with better prognosis
The phosphorylation-specific association of STMN1 with GRP78 (显示 HSPA5 蛋白) promotes breast cancer metastasis.
EGFR (显示 EGFR 蛋白) suppression of mitotic regulators including Rcc2 (显示 RCC2 蛋白) and Stathmin 1 are a mechanism for catagen induction in mouse skin
We identified stathmin as a key molecule aiding in septin (显示 SEPT6 蛋白)-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7 (显示 SEPT7 蛋白)-null fibroblasts
Overexpressing stathmin reduces complement receptor 3 (显示 ITGAM 蛋白)-mediated phagocytosis and cellular activation, implicating a pivotal inhibitory role for stathmin in classically activated macrophages.
Stathmin cooperates with p27(kip1 (显示 CDKN1B 蛋白)) to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression.
The protein profiles during murine embryo implantation were clarified. Stathmin 1 might be a potential regulator of embryo implantation.
Results show an important role for stathmin during adult neurogenesis in the subgranular zone of the mouse hippocampus; propose that stathmin controls the transition from neuronal precursors to early postmitotic neurons
Stathmin mutations disrupt changes in microtubule stability, GluA2 (显示 GRIA2 蛋白) localization, synaptic plasticity and memory.
Stmn deletion does not prolong the lifespan of spinal muscular atrophy-like mice, suggesting that stathmin dysregulation and microtubule disruption are not a cause but rather a consequence of SMA (显示 SMN1 蛋白) pathology.
stathmin expression is dispensable for tumor onset, at least in mice, thus making stathmin a virtually exclusive marker of aggressive disease and a promising therapeutic target for advanced cancers.
results demonstrate the mechanism of stathmin-dependent control of MT dynamics, Rho signaling, and permeability
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.
leukemia-associated phosphoprotein p18
, oncoprotein 18
, phosphoprotein 19
, phosphoprotein p19
, stathmin 1/oncoprotein 18
, transmembrane protein C1orf215
, leukemia associated phosphoprotein p18
, leukemia-associated gene protein
, leukemia-associated cytosolic phosphoprotein stathmin
, stathmin 1 a
, stathmin 1/oncoprotein 18b
, stathmin 1
, stathmin 1 b
, stathmin 1b
, stathmin clone XO35