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Human SIRT1 ELISA Kit for Sandwich ELISA - ABIN420531
Kilic, Gok, Bacaksiz, Izmirli, Elibol-Can, Uysal: SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases. in PLoS ONE 2014
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Rat (Rattus) SIRT1 ELISA Kit for Sandwich ELISA - ABIN434855
Rizk, El-Maraghy, Nassar: A novel role for SIRT-1 in L-arginine protection against STZ induced myocardial fibrosis in rats. in PLoS ONE 2014
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Li, Feng, Xing, Wang, Du, Xu, Cao, Wang, Fan, Liu, Fan: Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1. in International journal of molecular sciences 2014
Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.
SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.
SIRT1 knock-out embryos display reduced Mat2a (显示 MAT2A ELISA试剂盒) expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice.
The present study demonstrates that the aging heart is characterized by contractile dysfunction associated with increased oxidative stress and endoplasmic reticulum stress and Sirtuin 1 might have the ability to protect the aging hearts from the inhibition of endoplasmic reticulum-mediated apoptosis.
SIRT1 has the ability to effectively regulate the wear particle-induced inflammatory responses, apoptosis, osteolysis in particle-stimulated osteoblasts and particle-induced osteolysis animal models.
Taken together, our data indicated that increased expression of miR (显示 MLXIP ELISA试剂盒)-181b potentially contributes to altered lipid metabolism in NAFLD (显示 TSC2 ELISA试剂盒). Downregulation of miR (显示 MLXIP ELISA试剂盒)-34a may be a therapeutic strategy against NAFLD (显示 TSC2 ELISA试剂盒) by regulating its target SIRT1.
data demonstrate that resveratrol requires neuronal SIRT1 to elicit ischemic tolerance and identify a novel role for SIRT1 in the regulation of glycolytic function in brain.
The Sirt7 (显示 SIRT7 ELISA试剂盒) mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (显示 DNMT1 ELISA试剂盒) and another member of the sirtuin family, Sirt1.
findings reveal an unexpected mechanism for SIRT3 (显示 SIRT3 ELISA试剂盒) regulation via SIRT1-mediated deacetylation. Improving mitochondrial SIRT3 (显示 SIRT3 ELISA试剂盒) functions by inhibiting SIRT3 (显示 SIRT3 ELISA试剂盒) acetylation may offer a new therapeutic approach for obesity- and aging-related diseases associated with mitochondrial dysfunction.
THe data of this study supported that estrogen protects against ischemic stroke through preventing neuron death via the SIRT1-dependent AMPK (显示 PRKAA1 ELISA试剂盒) pathway
Models for post-menopausal and aging-related osteoporosis, respectively, show significant improvements in bone mass upon treatment with SIRT1 agonist, SRT1720. SIRT1 whole-body knockout (KO) mice, as well as osteoblast and osteoclast specific KOs, show a low bone mass phenotype. Results suggest that SIRT1 acts as a positive regulator of in vivo bone mass.
Genistein increases SIRT1 expression in renal cells after renal ischemia/reperfusion induced injury. These data indicate that SIRT1 may contribute to the protective effects of genistein on tubular damage and the loss of renal function in ischemia/reperfusion injury.
Association between SIRT1 variation and pediatric obesity in Korean children with a gender difference.
The results suggested that inhibition of glycolysis using sub-lethal doses of 2-DG down-regulated the expression of VEGF (显示 VEGFA ELISA试剂盒) and also significantly reduced its biological activity. Further mechanistic studies revealed that the down regulation of VEGF (显示 VEGFA ELISA试剂盒) gene expression by 2-DG was due to an increase in SIRT-1 activity
The present results suggest that resveratrol and EPA, but not DHA, markedly activated the SIRT1 gene expression in THP1 (显示 GLI2 ELISA试剂盒) cells, and that high glucose medium could inhibit the basic gene expression, but not powerful resveratrol-induced gene expression, in those cells.
Accordingly, our results demonstrated that NAMPT (显示 NAMPT ELISA试剂盒) is a prognostic marker in melanoma, and the identificationofNAMPT-E2F2 (显示 E2F2 ELISA试剂盒)-SIRT1 pathway establishes another link between NAMPT (显示 NAMPT ELISA试剂盒) and apoptosis events in melanoma, with therapeutic implications for this deadly cancer.
These data suggest that SIRT1 activates HBG expression through facilitating LCR looping to the HBG promoter, inhibiting the expression of transcriptional suppressors of HBG, and indirectly increasing histone acetylation in the HBG promoter.
Levels of miR106a are modulated during cellular migration, causing a change in the levels of SIRT-1 mRNA by affecting its stability and the levels of SIRT-1 in turn can regulate the levels of MMP9 (显示 MMP9 ELISA试剂盒).
Study demonstrated a functional role of the SIRT1/miR (显示 MLXIP ELISA试剂盒)-15b-5p/ACOX1 (显示 ACOX1 ELISA试剂盒) axis in CRC (显示 CALR ELISA试剂盒) metastasis.
These studies suggest SIRT1/PGC-1alpha (显示 PPARGC1A ELISA试剂盒) as underlying pathways contributing to AMD (显示 AMD1 ELISA试剂盒) pathophysiology.
SIRT1 protected LECs from oxidative stress via the inhibition of the p53 (显示 TP53 ELISA试剂盒) pathway. SIRT1 or SIRT1 activators could potentially be used to prevent ocular aging and cataract in the future.
Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.
SIRT1, p53 (显示 TP53 ELISA试剂盒) and NF-kappaB (显示 NFKB1 ELISA试剂盒) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
the expression of SIRT1 is associated with the Mt number in oocytes
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (显示 PNPLA2 ELISA试剂盒)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (显示 PPARG ELISA试剂盒) to that of ATGL (显示 PNPLA2 ELISA试剂盒) in adipocytes.
CDK5 (显示 CDK5 ELISA试剂盒)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
SIRT1 and LKB1 (显示 STK11 ELISA试剂盒)/AMPK (显示 PRKAA1 ELISA试剂盒) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.
Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (显示 FOXO1 ELISA试剂盒).
The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein
Downregulation of miR (显示 MYLIP ELISA试剂盒)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Sirt1 regulates the expression of FABP3 (显示 FABP3 ELISA试剂盒) gene in adipocytes, and PPAR gamma (显示 PPARG ELISA试剂盒) apparently plays an important role in this process.
The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.
Downregulation of SIRT1 and FoxO1 (显示 FOXO1 ELISA试剂盒) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.
Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.
5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits
The expression profile of sirtuin 1 and sirtuin 3 (显示 SIRT3 ELISA试剂盒) in the liver, muscle, and adipose tissue of calves and bulls is reported.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
, NAD-dependent deacetylase sirtuin-1
, NAD-dependent protein deacetylase sirtuin-1
, SIR2-like protein 1
, regulatory protein SIR2 homolog 1
, sir2-like 1
, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
, sirtuin type 1
, sirtuin (silent mating type information regulation 2 homolog) 1
, NAD-dependent deacetylase sirtuin 1