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anti-PAK2 (PAK2) 抗体产品概述

Full name:
anti-P21-Activated Kinase 2 抗体 (PAK2)
在www.antibodies-online.cn可供174 P21-Activated Kinase 2 (PAK2) 抗体的25不同的供货商。 再加上,我们可以发PAK2 试剂盒 (12)PAK2 蛋白 (11)和数多这个蛋白质的别的产品。 总共210 PAK2产品已列进来了。
别名:
5330420P17Rik, A130002K10Rik, AI836325, cb422, D16Ertd269e, gamma-PAK, kinase, mKIAA4182, PAK-2, pak2, Pak3, PAK65, PAKgamma, PAKI, si:dz198m22.1, wu:fb71h01, zgc:91798

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引用最多的anti-PAK2 抗体

  1. Human Polyclonal PAK2 Primary Antibody for EIA, IHC (p) - ABIN500439 : Jaffer, Chernoff: p21-activated kinases: three more join the Pak. in The international journal of biochemistry & cell biology 2002 (PubMed)
    Show all 4 references for ABIN500439

  2. Human Polyclonal PAK2 Primary Antibody for EIA, IHC (p) - ABIN500441 : Ang, Patel, Yin, Sundaram, Fritchie, Zhao, Liu, Freemerman, Wilkerson, Walter, Weissler, Shockley, Couch, Zanation, Hackman, Chera, Harris, Miller, Thorne, Hayward, Funkhouser, Olshan, Shores, Makowski, Hayes: High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011 (PubMed)
    Show all 4 references for ABIN500441

  3. Human Monoclonal PAK2 Primary Antibody for ICC, IHC - ABIN969338 : Chu, Wu, Liao, Pardo, Zhao, Li, Mendenhall, Pali, Shen, Yu, Taylor, Aversa, Molineaux, Payan, Masuda: A novel role for p21-activated protein kinase 2 in T cell activation. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
    Show all 2 references for ABIN969338

  4. Human Monoclonal PAK2 Primary Antibody for ELISA, ICC - ABIN2869426 : Machuy, Campa, Thieck, Rudel: c-Abl-binding protein interacts with p21-activated kinase 2 (PAK-2) to regulate PDGF-induced membrane ruffles. in Journal of molecular biology 2007 (PubMed)
    Show all 2 references for ABIN2869426

  5. Human Polyclonal PAK2 Primary Antibody for IHC (p), WB - ABIN318772 : Roig, Traugh: Cytostatic p21 G protein-activated protein kinase gamma-PAK. in Vitamins and hormones 2001 (PubMed)
    Show all 2 references for ABIN318772

  6. Human Polyclonal PAK2 Primary Antibody for IHC (p), WB - ABIN392433 : Benner, Dennis, Masaracchia: Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation. in The Journal of biological chemistry 1995 (PubMed)
    Show all 2 references for ABIN392433

  7. Human Polyclonal PAK2 Primary Antibody for EIA, IHC (p) - ABIN360318 : Martin, Bollag, McCormick, Abo: A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. in The EMBO journal 1995 (PubMed)
    Show all 2 references for ABIN360318

  8. Human Polyclonal PAK2 Primary Antibody for IHC, ELISA - ABIN1532071 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

  9. Human Polyclonal PAK2 Primary Antibody for IP, WB - ABIN253074 : Qu, Misaghi, Izrael-Tomasevic, Newton, Gilmour, Lamkanfi, Louie, Kayagaki, Liu, Kömüves, Cupp, Arnott, Monack, Dixit: Phosphorylation of NLRC4 is critical for inflammasome activation. in Nature 2012 (PubMed)

更多抗PAK2的相互作用对抗体

Zebrafish P21-Activated Kinase 2 (PAK2) interaction partners

  1. EphrinB ligands B2a and B3b, the Ephb4a (显示 EPHB4 抗体) receptor and the Pak2a kinase are required for the development of pharyngeal pouches and the segmentation of the posterior facial skeleton.

  2. Essential in vivo role for betaPix (显示 ARHGEF7 抗体) and Pak2a during embryonic development and a previously unrecognized pathway specifically involved in cerebrovascular stabilization. [BetaPix (显示 ARHGEF7 抗体) AND Pak2a]

  3. Data provide evidence for a critical function of Pak2 in vascular integrity and demonstrate a severe disease phenotype resulting from loss of Pak2 function.

Human P21-Activated Kinase 2 (PAK2) interaction partners

  1. We found that overexpression of miR (显示 MLXIP 抗体)-137 inhibited the proliferation of melanoma cells, which could be phenocopied by knockdown of PAK2 using siRNAs.

  2. PAK2 is a direct effector of TSC1 (显示 TSC1 抗体)-TSC2 (显示 TSC2 抗体)-RHEB (显示 RHEB 抗体) signaling and a new target for rational drug therapy in TSC (显示 SLC12A3 抗体).

  3. Nef exploits PAK2 in a stepwise mechanism in which its kinase activity cooperates with an adaptor function for the exocyst complex to inhibit host cell actin dynamics.

  4. Cytoplasmic Pak2 may promote cell proliferation in normal endometrium during menstrual cycle.

  5. Further analyses show that HDAC6 (显示 HDAC6 抗体) may promote growth of GBM cells through inhibition of SMAD2 (显示 SMAD2 抗体) phosphorylation to downregulate p21 (显示 CDKN1A 抗体)

  6. Pak1 (显示 PAK1 抗体) and Pak2 counteract centrosome separation in a kinase-dependent manner.

  7. Findings indicate that repression of microRNA miR (显示 MLXIP 抗体)-134 and consequent up-regulation of p21-activated kinase 2 (Pak2) might contribute to paclitaxel resistance.

  8. Inhibition of PAK activation at late G2-phase centrosomes caused by Rac1 inactivation coincides with impeded activation of Aurora A (显示 AURKA 抗体) and the CyclinB (显示 CCNB1 抗体)/Cdk1 (显示 CDK1 抗体) complex and delayed mitotic entry.

  9. Data show that group I p21 (显示 CDKN1A 抗体)-activated kinases (Paks) Pak1 (显示 PAK1 抗体) and Pak2 were much more abundant than Pak3 in meningioma.

  10. Results identified Pak2 as a possibly important mediator of ovarian cancer cell migration on extracellular matrix.

Mouse (Murine) P21-Activated Kinase 2 (PAK2) interaction partners

  1. Mechanistic insights into the role of Pak2 in hematopoietic stem cells migration and homing.

  2. Pak2 disruption decreased the survival and proliferation of multicytokine stimulated immature progenitors.

  3. The data suggest that Pak2 controls thymic Natural Killer T-cell development by providing a signal that links Egr2 (显示 EGR2 抗体) to induce PLZF (显示 ZBTB16 抗体), in part by regulating signaling lymphocyte activation molecule (显示 SLAMF1 抗体) 6 expression.

  4. In adult endothelial cells, Pak2 depletion leads to severe apoptosis and acute angiogenesis defects, and in adult mice, endothelial Pak2 deletion leads to increased vascular permeability.

  5. Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance

  6. Failure to induce proper actin cytoskeletal remodeling impaired PLCgamma1 and Erk1/2 signaling in the absence of Pak2, uncovering the critical function of Pak2 as an essential regulator that governs the actin cytoskeleton-dependent signaling

  7. thrombin (显示 F2 抗体) induces monocyte/macrophage migration via PAR1 (显示 F2R 抗体)-Galpha12 (显示 GNA12 抗体)-dependent Pyk2 (显示 PTK2B 抗体)-mediated Gab1 (显示 GAB1 抗体) and p115 RhoGEF (显示 ARHGEF1 抗体) interactions, leading to Rac1- and RhoA (显示 RHOA 抗体)-targeted Pak2 activation.

  8. p21 (显示 D4S234E 抗体)-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

  9. Pak2, but not Pak1 (显示 PAK1 抗体), negatively regulates RhoA (显示 RHOA 抗体) via phosphorylation of the guanine nucleotide exchange factor (显示 ARHGEF12 抗体) GEF-H1 (显示 ARHGEF2 抗体) at an inhibitory site, leading to increased GEF-H1 (显示 ARHGEF2 抗体) microtubule binding and loss of RhoA (显示 RHOA 抗体) stimulation

  10. Full-length PAK-2 rather than the caspase-activated PAK-2p34 is required for normal embryonic development.

Cow (Bovine) P21-Activated Kinase 2 (PAK2) interaction partners

  1. Basement membrane proteins promote PAK2 Ser (显示 SIGLEC1 抗体)-20 phosphorylation through enhanced eNOS (显示 NOS3 抗体) activation and NO production.

PAK2 抗原简介

Antigen Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

Alternative names and synonyms associated with PAK2

  • p21 (CDKN1A)-activated kinase 2a (pak2a) 抗体
  • p21 protein (Cdc42/Rac)-activated kinase 2 (pak2) 抗体
  • p21 protein (Cdc42/Rac)-activated kinase 2 (PAK2) 抗体
  • p21 protein (Cdc42/Rac)-activated kinase 2 (Pak2) 抗体
  • 5330420P17Rik 抗体
  • A130002K10Rik 抗体
  • AI836325 抗体
  • cb422 抗体
  • D16Ertd269e 抗体
  • gamma-PAK 抗体
  • kinase 抗体
  • mKIAA4182 抗体
  • PAK-2 抗体
  • pak2 抗体
  • Pak3 抗体
  • PAK65 抗体
  • PAKgamma 抗体
  • PAKI 抗体
  • si:dz198m22.1 抗体
  • wu:fb71h01 抗体
  • zgc:91798 抗体

Protein level used designations for PAK2

p21 (CDKN1A)-activated kinase 2 , p21-activated kinase 2 , redhead , rhd , serine/threonine-protein kinase PAK 2 , p21 activated kinase 2 , PAK-2 , S6/H4 kinase , gamma-PAK , p58 , p21-activated kinase I , p21-activated protein kinase I

GENE ID SPECIES
266749 Danio rerio
399090 Xenopus laevis
460965 Pan troglodytes
5062 Homo sapiens
224105 Mus musculus
29432 Rattus norvegicus
513673 Bos taurus
612814 Canis lupus familiaris
424860 Gallus gallus
100009535 Oryctolagus cuniculus
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