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Activation loop phosphorylation of ERK3/ERK4 by group I p21 (显示 CDKN1A 抗体)-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 (显示 MAPKAPK5 抗体) signaling pathway.
Data defined a novel MK5 (显示 MAPKAPK5 抗体) interaction motif (FRIEDE) within both ERK4 and ERK3 that is essential for binding to the C-terminal region of MK5 (显示 MAPKAPK5 抗体).
Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5 (显示 MAPKAPK5 抗体). Interaction of ERK4 with MAPKAPK-5 (显示 MAPKAPK5 抗体) leads to translocation of MAPKAPK-5 (显示 MAPKAPK5 抗体) to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3.
Results uncover a unique role for ERK3 (显示 RYK 抗体), dependent on its kinase activity, during T cell development and show that this atypical MAPK (显示 MAPK1 抗体) is essential to sustain CD4 (显示 CD4 抗体)(+) CD8 (显示 CD8A 抗体)(+) (DP) thymocytes survival during RAG-mediated rearrangements.
The atypical MAPK (显示 MAPK1 抗体) ERK3 (显示 RYK 抗体) is a new and important regulator of T cell receptor-induced T cell activation.
Data suggest that ERK3 (显示 RYK 抗体) is crucial for spindle stability and required for the metaphase-anaphase transition in mouse oocyte maturation.
Data suggest that Erk4 is dispensable for mouse embryonic development and reveals that Erk3 (显示 RYK 抗体) and Erk4 have acquired specialized functions through evolutionary diversification.
a critical role for Erk3 (显示 RYK 抗体) in the establishment of fetal growth potential and pulmonary function in the mouse
Data show that in contrast to ERK3 (显示 RYK 抗体), ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5 (显示 MAPKAPK5 抗体). Interaction of ERK4 with MAPKAPK-5 (显示 MAPKAPK5 抗体) leads to translocation of MAPKAPK-5 (显示 MAPKAPK5 抗体) to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3 (显示 RYK 抗体).
Data show that MPK4 phosphorylation of MYB75 increases its stability and is essential for light-induced anthocyanin accumulation. Our findings reveal an important role for a MAPK (显示 MAPK1 抗体) pathway in light signal transduction.
ASR3 functions as a transcriptional repressor regulated by microbe-associated molecular patterns-activated MPK4 to fine-tune plant immune gene expression.
Mitogen-activated protein kinase 4 is a salicylic acid-independent regulator of growth but not of photosynthesis in Arabidopsis
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 activation concomitantly with MEKK1 (显示 MAP3K1 抗体) and MKK2 (显示 MAP2K2 抗体) phosphorylation.
Data indicate that MEKK2 (显示 MAP3K2 抗体) is required for the mekk1 (显示 MAP3K1 抗体), mkk1 (显示 MAP2K1 抗体) mkk2 (显示 MAP2K2 抗体), and mpk4 autoimmune phenotypes.
Arabidopsis MPK4 can interact with and be phosphorylated by the cytokinesis-related MAP kinase (显示 MAPK1 抗体) kinase, AtMKK6 (显示 MAP2K6 抗体).
MPK4 activity was found to compromise effector-triggered immunity conditioned by the Toll Interleukin-1 Receptor-nucleotide binding (NB)-Leu-rich repeat (LRR) receptors RPS4 and RPP4 but not by the coiled coil-NB-LRR receptors RPM1 and RPS2.
Data suggest that the MEKK1 (显示 MAP3K1 抗体)-MKK1 (显示 MAP2K1 抗体)/MKK2 (显示 MAP2K2 抗体)-MPK4 kinase cascade negatively regulates MEKK2 (显示 MAP3K2 抗体) and activation of MEKK2 (显示 MAP3K2 抗体) triggers SUMM2-mediated immune responses.
Findings show that seedling survival of prolonged oxygen deprivation was improved in transgenics that ectopically overexpress MPK3 (显示 MAPK3 抗体), MPK4 and MPK6 (显示 MAPK6 抗体).
MKS1 function and subcellular location requires an intact N-terminus important for both MPK4 and WRKY33 interactions
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.
, MAP kinase 4
, MAP kinase isoform p63
, extracellular signal-regulated kinase 4
, MAPK 4
, mitogen activated protein kinase 4