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|抗原||Mitogen-Activated Protein Kinase 3 (MAPK3) 抗体|
|抗原表位||AA 325-345 其他选择|
|适用||小鸡, 犬, Frog, 人, 小鼠, 大鼠 其他选择|
|标记||This MAPK3 antibody is un-conjugated 其他选择|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|Supplier||Log in to see|
MAPK3抗体详情MAPK3目标详情 使用细节 贮存及处理 ProductDetails: References for anti-MAPK3 antibody (ABIN967700) 图像
|交叉反应||小鼠, 人, 小鸡, 犬, Frog|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|纯化方法||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|免疫原||Rat ERK1 aa. 325-345|
MAPK3目标详情MAPK3抗体详情 使用细节 贮存及处理 ProductDetails: References for anti-MAPK3 antibody (ABIN967700) 图像 回页首
|别名||ERK1 (MAPK3 Antibody 摘要)|
|背景||The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) is activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK1 is a 44 kDa member of the ERK family and shares 85% homology with ERK2 (42 kDa).|
|研究领域||Stem Cells, Alzheimer's Disease, Signaling, Inflammation|
|途径||MAPK Pathway, RTK signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals|
使用细节MAPK3抗体详情 MAPK3目标详情 贮存及处理 ProductDetails: References for anti-MAPK3 antibody (ABIN967700) 图像 回页首
Related Products: ABIN968545, ABIN967389
贮存及处理MAPK3抗体详情 MAPK3目标详情 使用细节 ProductDetails: References for anti-MAPK3 antibody (ABIN967700) 图像 回页首
|缓冲液||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|储存方法||Store undiluted at -20°C.|
ProductDetails: References for anti-MAPK3 antibody (ABIN967700)MAPK3抗体详情 MAPK3目标详情 使用细节 贮存及处理 图像 回页首
Nowak: "Protein kinase C-alpha and ERK1/2 mediate mitochondrial dysfunction, decreases in active Na+ transport, and cisplatin-induced apoptosis in renal cells." in: The Journal of biological chemistry, Vol. 277, Issue 45, pp. 43377-88, 2002
Aguirre-Ghiso, Liu, Mignatti, Kovalski, Ossowski: "Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo." in: Molecular biology of the cell, Vol. 12, Issue 4, pp. 863-79, 2001
Ackerley, Grierson, Brownlees, Thornhill, Anderton, Leigh, Shaw, Miller: "Glutamate slows axonal transport of neurofilaments in transfected neurons." in: The Journal of cell biology, Vol. 150, Issue 1, pp. 165-76, 2000
Wan, Huang: "Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells." in: The Journal of biological chemistry, Vol. 273, Issue 23, pp. 14533-7, 1998
Reszka, Seger, Diltz, Krebs, Fischer: "Association of mitogen-activated protein kinase with the microtubule cytoskeleton." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8881-5, 1995
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