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Authors report that miR (显示 MLXIP ELISA试剂盒)-199a-5p and let-7c cooperatively and efficiently inhibit HCC (显示 FAM126A ELISA试剂盒) cell migration and invasion by targeting the metastasis promoter MAP4K3 and MAP4K3-mediated drug sensitization.
This report details the first structure of GLK (显示 GCK ELISA试剂盒); comparison of its activation loop sequence and P-loop structure to that of Map4k4 (显示 MAP4K4 ELISA试剂盒) suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors.
ITGB3 (显示 ITGB3 ELISA试剂盒) and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells.
MAP4K3 expression is required for leucine-induced mTORC1 activation in human primary fibroblasts.
Significantly higher median frequencies of circulating GLK (显示 GCK ELISA试剂盒)-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001).
Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A (显示 PPP2R4 ELISA试剂盒)(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling.
MAP4K3 orchestrates activation of BAX (显示 BAX ELISA试剂盒) via the concerted posttranscriptional modulation of PUMA (显示 BBC3 ELISA试剂盒), BAD, and BIM (显示 BCL2L11 ELISA试剂盒).
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
MAPK/ERK kinase kinase kinase 3
, MEK kinase kinase 3
, germinal center kinase-like kinase
, germinal center kinase-related protein kinase
, MEKKK 3
, mitogen activated protein kinase kinase kinase kinase 3