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Human MAP3K5 ELISA Kit for Sandwich ELISA - ABIN416968
Padmini, Tharani: Heat-shock protein 70 modulates apoptosis signal-regulating kinase 1 in stressed hepatocytes of Mugil cephalus. in Fish physiology and biochemistry 2014
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Apoptosis signal-regulating kinase 1 (ASK1) expression was dramatically suppressed and correlated with hepatocyte nuclear factor 4alpha (HNF4alpha (显示 HNF4A ELISA试剂盒)) levels in hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) tissues.
ASK1 phosphorylated and stabilized TLX (显示 CD46 ELISA试剂盒), which led induction of HIF-1alpha (显示 HIF1A ELISA试剂盒), and its downstream VEGF-A (显示 VEGFA ELISA试剂盒) in an Akt (显示 AKT1 ELISA试剂盒) dependent manner.
CD40 (显示 CD40 ELISA试剂盒) activation resulted in down-regulation of Thioredoxin (Trx)-1 (显示 TXN ELISA试剂盒) to permit ASK1 activation and apoptosis. Although soluble receptor (显示 IFNAR1 ELISA试剂盒) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 (显示 CD40 ELISA试剂盒) agonist and pharmacological inhibition of Trx-1 (显示 MLL ELISA试剂盒) was functionally equivalent to the signal triggered by mCD40L
These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis.
from the two catalytic cysteines of TRX1 (显示 MLL ELISA试剂盒) the residue C32 (显示 CKLF ELISA试剂盒) is responsible for the high-affinity binding of TRX1 (显示 MLL ELISA试剂盒) to the ASK1-TRX (显示 VAC14 ELISA试剂盒)-binding domain in reducing conditions
Shotgun mass spectrometry and manual validation identified 12 distinct ASK1 phosphosites. Targeted parallel reaction monitoring assays were used to track the phosphorylation dynamics of each confirmed site in response to treatment.
phosphorus NMR and time-resolved tryptophan fluorescence measurements suggest that 14-3-3zeta (显示 YWHAZ ELISA试剂盒) interacts with the kinase domain of ASK1 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation.
ASK1 MAP kinase (显示 MAPK1 ELISA试剂盒) signaling cascade is an important regulator of chondrocyte terminal differentiation.
Pretreatment by IRE1 (显示 ERN1 ELISA试剂盒) agonist tunicamycin or JNK (显示 MAPK8 ELISA试剂盒) agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1 (显示 ERN1 ELISA试剂盒)-ASK1-JNK (显示 MAPK8 ELISA试剂盒) pathway
Our results thus suggest that GSK-3beta (显示 GSK3b ELISA试剂盒) is a key factor involved in ASK1 activation and reactive oxygen species-induced cell death.
PBL27 interacts with both CERK1 and the MAPK (显示 MAPK1 ELISA试剂盒) kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK (显示 MAPK1 ELISA试剂盒) kinase activation and disease resistance to Alternaria brassicicola.
The results of this investigation indicate ASK1 inhibition prolongs keratinocyte and blastemal cell activation leading to ear regeneration.
Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
These results demonstrate that trans-fatty acids promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA (显示 F3 ELISA试剂盒)-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of trans-fatty acids-induced atherosclerosis.
Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (显示 AKT1 ELISA试剂盒)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (显示 AKT1 ELISA试剂盒) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.
ASK1 mediates astrocyte activation and leads to glial scar formation after cerebral ischaemia.
ASK1 mediates 3-NP toxicity and regulates C1q level through the astrocyte TGF-beta (显示 TGFB1 ELISA试剂盒).
ASK1 signalling regulates brown and beige (显示 LYST ELISA试剂盒) adipocyte function.
blocking MPTP (显示 PTPN2 ELISA试剂盒)-mediated TNF (显示 TNF ELISA试剂盒) signaling through intrathecal administration of TNF (显示 TNF ELISA试剂盒)-neutralizing antibody prevented Trx1 (显示 TXN ELISA试剂盒) oxidation and downstream ASK1-p38 MAPK (显示 MAPK14 ELISA试剂盒) activation
PP2A and AIP1 (显示 PDCD6IP ELISA试剂盒) cooperatively induce activation of ASK1-JNK (显示 MAPK8 ELISA试剂盒) signaling and vascular endothelial cell apoptosis.
These results indicate an important regulatory role of ASK1 in porcine circovirus type 2-induced apoptotic responses.
MAP3K5 is expressed in the heart, liver, spleen, lung, kidney, muscle, fat, pancrea, ileum, and stomach tissues of pigs.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells\; MAPKKK5 does not activate MAPK/ERK.
, MAP/ERK kinase kinase 5
, MAPK/ERK kinase kinase 5
, MEK kinase 5
, MEKK 5
, apoptosis signal regulating kinase 1
, apoptosis signal-regulating kinase 1
, mitogen activated protein kinase kinase kinase 5
, mitogen-activated protein kinase kinase kinase 5
, mitogen-activated protein kinase kinase kinase 5 pseudogene