Use your antibodies-online credentials, if available.
miR (显示 MLXIP ELISA试剂盒)-34c-3p may regulate triple-negative breast cancer progression by directly targeting the 3'-untranslated region of mitogen-activated protein kinase kinase kinase 2 (MAP3K2).
Study found miR (显示 MLXIP ELISA试剂盒)-186 expression significantly decreased in lung cancer tissues and cells and MAP3K2 expression increased in the same cancer tissues. Also, results confirmed that MAP3K2 is a target gene of miR (显示 MLXIP ELISA试剂盒)-186 and both expression correlated with prognosis.
SMYD3 (显示 SMYD3 ELISA试剂盒)-mediated methylation of MAP3K2 increases mutant K-Ras (显示 HRAS ELISA试剂盒)-induced activation of ERK1/2 (显示 MAPK1/3 ELISA试剂盒). (Review)
Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2
HBXIP (显示 HBXIP ELISA试剂盒) activated ERK1/2 (显示 MAPK1/3 ELISA试剂盒) through up-regulating MEKK2.
MEKK2 has a novel function as a regulator of ubiquitylation-dependent paxillin (显示 PXN ELISA试剂盒) redistribution in breast tumour cells.
EBV microRNA BART (显示 BSND ELISA试剂盒) 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells.
Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2/3-MEK5 (显示 MAP2K5 ELISA试剂盒)-ERK5 (显示 MAPK7 ELISA试剂盒) signaling.
methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas
results strongly support a role for MEKK2 as a regulator of signaling that modulates breast tumor cell spread area and migration through control of focal adhesion stability
FGF2 (显示 FGF2 ELISA试剂盒)/MEKK2 pathway mediates an alternative nonclassical pathway for beta-catenin (显示 CTNNB1 ELISA试剂盒) activation, and this pathway is a key regulator of bone formation by osteoblasts
Stk38 (显示 STK38 ELISA试剂盒) protein kinase (显示 CDK7 ELISA试剂盒) has a role in inhibiting TLR9 (显示 TLR9 ELISA试剂盒)-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
MEKK2 is regulated through a phosphorylation-dependent association with 14-3-3 (显示 YWHAQ ELISA试剂盒), a group of adapters that modulate dimerization and association between proteins
MEKK2 signaling contributes to right ventricular hypertrophy and altered myocardial inflammatory gene expression in response to hypoxia-induced pulmonary hypertension.
MEKK2 alone can suppress T-cell TGF-beta (显示 TGFB1 ELISA试剂盒) responses. MEKK2 or MEKK3 (显示 MAP3K3 ELISA试剂盒) can cause ERK1/2 (显示 MAPK1/3 ELISA试剂盒) to phosphorylate SMAD2 (显示 SMAD2 ELISA试剂盒)/3 and suppress R-SMAD (显示 SMAD1 ELISA试剂盒)-dependent transcription. MEKK2 and MEKK3 (显示 MAP3K3 ELISA试剂盒) play overlapping roles in regulating Th-cell differentiation via TGF-beta (显示 TGFB1 ELISA试剂盒)
Data show that HDAC4 (显示 HDAC5 ELISA试剂盒) binds and promotes the deacetylation and activation of a key MAP3 kinase, MEKK2.
Data from experiments with Mekk2(-/-) mice show that MEKK2 may be required for controlling the strength of T cell receptor/CD3 (显示 CD3E ELISA试剂盒) signaling.
PB1 domain mediates the association of MEKK2 and MEKK3 (显示 MAP3K3 ELISA试剂盒) with MEK5 (显示 MAP2K5 ELISA试剂盒) and that the respective PB1 domains of these kinases are critical for regulation of the ERK5 (显示 MAPK7 ELISA试剂盒) pathway.
Rap1 (显示 TERF2IP ELISA试剂盒) and MEKK2 are critical upstream signaling molecules mediating BDNF (显示 BDNF ELISA试剂盒) stimulation of ERK5 (显示 MAPK7 ELISA试剂盒) in central nervous system neurons
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.
mitogen-activated protein kinase kinase kinase 2
, MAP/ERK kinase kinase 2
, MAPK/ERK kinase kinase 2
, MEK kinase 2
, MEKK 2
, mitogen activated protein kinase kinase kinase 2
, protein kinase MEKK2b