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In lipotoxic hepatocytes, MLK3 activates a MAPK (显示 MAPK1 ELISA试剂盒) signaling cascade, resulting in the activating phosphorylation of STAT1 (显示 STAT1 ELISA试剂盒), and CXCL10 (显示 CXCL10 ELISA试剂盒) transcriptional upregulation.
Data indicate that BTG2 (显示 BTG2 ELISA试剂盒), MAP3K11, RPS6KA1 (显示 RPS6KA1 ELISA试剂盒) and PRDM1 (显示 PRDM1 ELISA试剂盒) as putative targets of microRNA miR (显示 MLXIP ELISA试剂盒)-125b.
Increased expression of MAP3K11 is associated with esophageal cancer.
During hepatocyte lipotoxicity, activated MLK3 induces the release of CXCL10 (显示 CXCL10 ELISA试剂盒)-bearing vesicles from hepatocytes, which are chemotactic for macrophages.
MLK3 serves as a common upstream kinase of AMPK (显示 PRKAA1 ELISA试剂盒) and JNK (显示 MAPK8 ELISA试剂盒) and functions as a direct upstream kinase for AMPK (显示 PRKAA1 ELISA试剂盒) independent of LKB1 (显示 STK11 ELISA试剂盒)
MLK3 represents a newly recognized integral component of HER2 (显示 ERBB2 ELISA试剂盒) biology in HER2 (显示 ERBB2 ELISA试剂盒)+ breast tumors.
MLK3 is a critical factor controlling the activity of kinase networks that control the cellular responses to different concentrations of reactive oxygen species.
Signaling pathways associated with the Pro252His mutation in MLK3 are located in the kinase domain which is an important domain for the regulation of downstream signaling pathways.
CHIP modulates MLK3 protein levels in response to Geldanamycin and stress stimuli, and CHIP-dependent regulation of MLK3 is required for suppression of SKOV3 ovarian cancer cell invasion.
Data indicate URMC-099 as an orally bioavailable, potent mixed lineage kinase 3 MLK3 inhibitor.
In lipotoxic hepatocytes, MLK3 (显示 KCNK7 ELISA试剂盒) activates a MAPK (显示 MAPK1 ELISA试剂盒) signaling cascade, resulting in the activating phosphorylation of STAT1 (显示 STAT1 ELISA试剂盒), and CXCL10 (显示 CXCL10 ELISA试剂盒) transcriptional upregulation.
MAP3K11 might function as an important tumor suppressor neutralized by oncomiR-125b in B-cell leukemia.
During hepatocyte lipotoxicity, activated MLK3 (显示 KCNK7 ELISA试剂盒) induces the release of CXCL10 (显示 CXCL10 ELISA试剂盒)-bearing vesicles from hepatocytes, which are chemotactic for macrophages.
TRB3 (显示 TRIB3 ELISA试剂盒)(-/-) islets show a decrease in both the amplitude and duration of cytokine-stimulated MLK3 (显示 KCNK7 ELISA试剂盒) induction and JNK (显示 MAPK8 ELISA试剂盒) activation.
MLK3 (显示 KCNK7 ELISA试剂盒) limits RhoA (显示 RHOA ELISA试剂盒) activation and injury-induced neointima formation by binding to and inhibiting the activation of p63Rho guanine nucleotide exchange factor (显示 ARHGEF12 ELISA试剂盒), a RhoA (显示 RHOA ELISA试剂盒) activator.
Genetic or pharmacologic inhibition of MLK3 (显示 KCNK7 ELISA试剂盒) blocks fMLP (显示 FPR1 ELISA试剂盒)-mediated motility of neutrophils both in vitro and in vivo, suggesting that MLK3 (显示 KCNK7 ELISA试剂盒) may be a therapeutic target in human diseases characterized by exuberant neutrophil migration.
Data from knockout mice suggest that MLK3 (显示 KCNK7 ELISA试剂盒) plays role in saturated fatty acid-induced activation of MAP kinase (显示 MAPK1 ELISA试剂盒) signaling; MLK3 (显示 KCNK7 ELISA试剂盒) appears to be involved in pathogenesis of obesity, adipose tissue in fl ammation, insulin (显示 INS ELISA试剂盒) resistance, and fatty liver disease.
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 (显示 MAPK8IP1 ELISA试剂盒) scaffold protein (显示 HOMER1 ELISA试剂盒) in cytokine-induced pancreatic beta cell death
These results reveal a novel role for MLK3 (显示 KCNK7 ELISA试剂盒) signaling in the regulation of intestinal epithelial migration in vivo and suggest that MLK3 (显示 KCNK7 ELISA试剂盒) may be an important target for the regulation of intestinal mucosal healing.
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
SH3 domain-containing proline-rich kinase
, mixed lineage kinase 3
, protein-tyrosine kinase PTK1
, src-homology 3 domain-containing proline-rich kinase
, mitogen activated protein kinase kinase kinase 11