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Data indicate that mitogen-activated protein kinase kinase 6 (MKK6) levels were substantially higher in monocytes than in neutrophils.
Data show significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls.
uncover a new mechanism of deactivation of MKK6-p38 (显示 CRK ELISA试剂盒) and substantiate a novel regulatory role of FBXO31 (显示 FBXO5 ELISA试剂盒) in stress response
Serine phosphorylation of p66shc (显示 SHC1 ELISA试剂盒) is carried out by active MKK6. beta-Amyloid-induced ROS (显示 ROS1 ELISA试剂盒) production and apoptosis increased in the presence of MKK6 and p66shc (显示 SHC1 ELISA试剂盒), which directly associate.
The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1 (显示 MAP3K5 ELISA试剂盒), and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.
crystal structure of human non-phosphorylated MAP2K6 (npMAP2K6) complexed with an ATP analogue was determined at 2.6 A resolution and represents an auto-inhibition state of MAP2K6
Data suggest aberrant MAP2K protein (MKK3 (显示 MAP2K3 ELISA试剂盒), MKK4 (显示 MAP2K4 ELISA试剂盒), MKK6, and MKK7 (显示 MAP2K7 ELISA试剂盒)) expression indicates that altered cellular signal transduction mediated via JNK (显示 MAPK8 ELISA试剂盒) and p38 (显示 CRK ELISA试剂盒) may be common in bladder cancer.
the balance between MKK6 and MKK3 (显示 MAP2K3 ELISA试剂盒) mediates p38 MAPK (显示 MAPK14 ELISA试剂盒) associated resistance to cisplatin in NSCLC
activation by mechanical stretch induces HMGB1 (显示 HMGB1 ELISA试剂盒) and cytokine expression in A549 cells
Results suggest that the p38alpha (显示 MAPK14 ELISA试剂盒), MAPK (显示 MAPK1 ELISA试剂盒), and MKK6 play prominent roles in IL-1beta (显示 IL1B ELISA试剂盒) and C/EBP-beta (显示 CEBPB ELISA试剂盒)-mediated C3 gene expression in astrocytes.
MAP2K6 functions in mouse testis determination, via positive effects on Sry (显示 SRY ELISA试剂盒), and a minor role for MAP2K3 (显示 MAP2K3 ELISA试剂盒).
MKK3 (显示 MAP2K3 ELISA试剂盒) and MKK6 differentially regulate bone loss due to estrogen withdrawal. MKK3 (显示 MAP2K3 ELISA试剂盒) directly mediates osteoclastogenesis while MKK6 likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.
Activation of distinct p38MAPK (显示 MAPK14 ELISA试剂盒) isoforms is regulated by the selective and synchronized action of two kinases, MKK3 (显示 MAP2K3 ELISA试剂盒) and MKK6, in response to cell stress.
MKK6 is downreglated in peripheral CD4 (显示 CD4 ELISA试剂盒)(+)T cells
p38alpha (显示 MAPK14 ELISA试剂盒) can negatively regulate the stability of the MKK6 mRNA and thus control the steady-state concentration of one of its upstream activators
Involvement of MKK6 in apoptotic cell death in thymocytes.
MKK6 is one of three different protein kinases which activate p38 MAPK (显示 MAPK14 ELISA试剂盒) in vitro.
MKK3 (显示 MAP2K3 ELISA试剂盒) and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses
increased activity of Sox9 (显示 SOX9 ELISA试剂盒) accounts at least in part for the phenotype caused by constitutive activation of MKK6 in chondrocytes
These results indicate that TAK1 (显示 NR2C2 ELISA试剂盒) and MKK6 constitute the p38 (显示 CRK ELISA试剂盒) signalling pathway to participate to Oc differentiation by RANKL (显示 TNFSF11 ELISA试剂盒) through p65 (显示 NFkBP65 ELISA试剂盒) phosphorylation and NFATc1 (显示 NFATC1 ELISA试剂盒) induction.
Arabidopsis MPK4 (显示 MAPK4 ELISA试剂盒) can interact with and be phosphorylated by the cytokinesis-related MAP kinase (显示 MAPK1 ELISA试剂盒) kinase, AtMKK6.
AtMKK6-AtMPK13 (显示 MAPK1/3 ELISA试剂盒) module positively regulates lateral root formation.
Plants with mutations in the MKK6/ANQ gene exhibit severe defects in cytokinesis.
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
MAPK/ERK kinase 6
, MAPKK 6
, MEK 6
, SAPK kinase 3
, dual specificity mitogen-activated protein kinase kinase 6
, protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
, stress-activated protein kinase kinase 3
, MAP kinase kinase 6
, mitogen activated protein kinase kinase 6
, protein kinase, mitogen activated, kinase 6
, mitogen-activated protein kinase kinase 3