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MEK2 was essential for the phosphorylation of MKK3 (显示 MAP2K3 蛋白)/MKK6 (显示 MAP2K6 蛋白) and p38 MAPK (显示 MAPK14 蛋白) that directly impacted on cyclin D1 (显示 CCND1 蛋白) expression.
High MEK2 expression is associated with inflammation.
there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (显示 ICAM1 蛋白)), ezrin (EZR (显示 EZR 蛋白)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3 (显示 NANOS3 蛋白)) gene expressions in metabolic syndrome patients.
The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (显示 PTPN11 蛋白)) syndrome
Data show that mitogen-activated protein kinase (显示 MAPK1 蛋白) kinases MEK1 (显示 MAP2K1 蛋白)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.
the purpose of this paper was to investigate MAPK (显示 MAPK1 蛋白) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (显示 MAP2K1 蛋白)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (显示 MAP2K1 蛋白)/2
Endocytosis separates EGF (显示 EGF 蛋白) receptors from endogenous fluorescently labeled HRas (显示 HRAS 蛋白) and diminishes receptor signaling to MAP kinases in endosomes.
MEK1 (显示 MAP2K1 蛋白) levels are upregulated at transcriptional level whereas MEK2 levels are downregulated at posttranslational level.
MEK1/2 inhibitor trametinib showed similar PFS and a response rate as docetaxel in patients with previously treated KRAS-mutant-positive non-small cell lung carcinoma.
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
fluid shear stress induces autocrine TGF-beta (显示 TGFB1 蛋白)/ALK5 (显示 TGFBR1 蛋白)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (显示 MAP2K1 蛋白)/2-mediated signaling.
FGF2 (显示 FGF2 蛋白) is an extracellular inducer of COUP-TFII (显示 NR2F2 蛋白) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (显示 NR2F2 蛋白) expression prior to the onset of osteogenic differentiation
REDD1 (显示 DDIT4 蛋白) is required for normal insulin (显示 INS 蛋白)-stimulated signaling, and a subtle balance exists between MEK1 (显示 MAP2K1 蛋白)/2, REDD1 (显示 DDIT4 蛋白), and mTOR (显示 FRAP1 蛋白)
MEK1 (显示 MAP2K1 蛋白) and MEK2 can substitute for each other but a minimum amount of MEK (显示 MDK 蛋白) is critical for placenta development and embryo survival
MK2 (显示 KCNA2 蛋白)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
MK2 (显示 KCNA2 蛋白) attenuates dendritic cell-mediated Th1 (显示 HAND1 蛋白) differentiation and autoimmune encephalomyelitis.
analysis of p38 (显示 CRK 蛋白)-MK2 (显示 KCNA2 蛋白)-activated Rsk (显示 RPS6KA1 蛋白) signaling in toll (显示 TLR4 蛋白)-like receptor-stimulated dendritic cells
both MEK1 (显示 MAP2K1 蛋白) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract
MK2 (显示 KCNA2 蛋白) is responsible for resistance of p53 (显示 TP53 蛋白)-deficient tumors to cisplatin
the AtMKK2-AtMPK10 (显示 MAPK10 蛋白) MAPK (显示 MAPK1 蛋白) module regulates leaf venation complexity by altering polar auxin transport efficiency
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (显示 MAPK4 蛋白) activation concomitantly with MEKK1 (显示 MAP3K1 蛋白) and MKK2 phosphorylation.
Ca(2 (显示 CA2 蛋白)+) signaling occurred upstream of the MEKK1 (显示 MAP3K1 蛋白)-MKK2 pathway. MEKK1 (显示 MAP3K1 蛋白) was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (显示 MAP3K1 蛋白).
Data indicate that MEKK2 (显示 MAP3K2 蛋白) is required for the mekk1 (显示 MAP3K1 蛋白), mkk1 (显示 MAP2K1 蛋白) mkk2, and mpk4 (显示 MAPK4 蛋白) autoimmune phenotypes.
Data suggest that the MEKK1 (显示 MAP3K1 蛋白)-MKK1 (显示 MAP2K1 蛋白)/MKK2-MPK4 (显示 MAPK4 蛋白) kinase cascade negatively regulates MEKK2 (显示 MAP3K2 蛋白) and activation of MEKK2 (显示 MAP3K2 蛋白) triggers SUMM2-mediated immune responses.
Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
double loss-of-function mutant (mkk1 (显示 MAP2K1 蛋白)/2) of MKK1 (显示 MAP2K1 蛋白) and MKK2 is shown to have marked phenotypes in development and disease
Activation of MPK4 (显示 MAPK4 蛋白) by flg22 is impaired in the mkk1 (显示 MAP2K1 蛋白) mkk2 double mutants, suggesting that MKK1 (显示 MAP2K1 蛋白) and MKK2 function together with MPK4 (显示 MAPK4 蛋白) and MEKK1 (显示 MAP3K1 蛋白) in a MAP kinase (显示 MAPK1 蛋白) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
ERK activator kinase 2
, MAP kinase kinase 2
, MAPK/ERK kinase 2
, MAPKK 2
, MEK 2
, dual specificity mitogen-activated protein kinase kinase 2
, mitogen-activated protein kinase kinase 2, p45
, MAP kinase/Erk kinase
, mitogen activated protein kinase kinase 2
, protein kinase, mitogen activated, kinase 2, p45
, dual specificity mitogen activated protein kinase kinase 2
, mitogen-activated protein kinase kinase type 2