MAP2K1 蛋白 (MAP2K1)产品概述

Full name:
Mitogen-Activated Protein Kinase Kinase 1 蛋白 (MAP2K1)
在www.antibodies-online.cn可供22 Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) 蛋白的9不同的供货商。 再加上,我们可以发MAP2K1 抗体 (619)MAP2K1 试剂盒 (31)和数多这个蛋白质的别的产品。 总共711 MAP2K1产品已列进来了。
别名:
ATMEK1, CFC3, F20B18.180, F20B18_180, MAP kinase/ ERK kinase 1, MAPKK1, MEK, mek-2, MEK1, MEKK1, MITOGEN ACTIVATED PROTEIN KINASE KINASE, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1, MKK1, NMAPKK, Prkmk1, si:ch211-242m18.2, wu:fj56a12, wu:fj61b01, zgc:56557
列出全部蛋白 基因 基因ID UniProt
MAP2K1 170851 Q01986
MAP2K1 5604 Q02750
MAP2K1 26395 P31938

显示所有的同义词

按照种类MAP2K1 蛋白 (MAP2K1)

选择适合您要求的种类

引用最多的MAP2K1 蛋白

  1. Mouse (Murine) MAP2K1 Protein expressed in Baculovirus infected Insect Cells - ABIN3216428 : Duesbery, Webb, Leppla, Gordon, Klimpel, Copeland, Ahn, Oskarsson, Fukasawa, Paull, Vande Woude: Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 4 references for 3216428

更多MAP2K1互动伙伴

Human Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. MEK1 is constitutively and mainly phosphorylated at the Thr (显示 TRH 蛋白)-292, Ser (显示 SIGLEC1 蛋白)-298, Thr (显示 TRH 蛋白)-386, and Thr (显示 TRH 蛋白)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (显示 TRH 蛋白)-292, Ser (显示 SIGLEC1 蛋白)-298, Thr (显示 TRH 蛋白)-386, and Thr (显示 TRH 蛋白)-388 residues vary widely during activation and deactivation of the MAPK (显示 MAPK1 蛋白) pathway.

  2. TNFRSF14 (显示 TNFRSF14 蛋白) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.

  3. There was no statistically significant association between BRAF (显示 BRAF 蛋白) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.

  4. High MEK1 expression is associated with inflammation.

  5. Lgr4 (显示 LGR4 蛋白) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) pathways.

  6. somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation

  7. MEK1 mutation is associated with central nervous system metastases of non-small cell lung cancer.

  8. The MAP2K1 mutation analysis of three hairy cell leukemia cases, one hairy cell leukemia-variant case, and three splenic marginal zone lymphoma cases revealed negative results.

  9. Data show that mitogen-activated protein kinase (显示 MAPK1 蛋白) kinases MEK1/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

  10. the purpose of this paper was to investigate MAPK (显示 MAPK1 蛋白) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Lgr4 (显示 LGR4 蛋白) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) pathways.

  2. FGF2 (显示 FGF2 蛋白) is an extracellular inducer of COUP-TFII (显示 NR2F2 蛋白) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (显示 NR2F2 蛋白) expression prior to the onset of osteogenic differentiation

  3. REDD1 (显示 DDIT4 蛋白) is required for normal insulin (显示 INS 蛋白)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (显示 DDIT4 蛋白), and mTOR (显示 FRAP1 蛋白)

  4. blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (显示 LEPR 蛋白) mice

  5. MEK1 and MEK2 (显示 MAP2K2 蛋白) can substitute for each other but a minimum amount of MEK (显示 MDK 蛋白) is critical for placenta development and embryo survival

  6. Aberrant phosphorylation of AKT (显示 AKT1 蛋白) and MEK (显示 MDK 蛋白) signalling pathways was identified in cells carrying mutant huntingtin (显示 HTT 蛋白).

  7. An essential function for MEK1 in macrophages in regulating the ERK1/2 and STAT4 (显示 STAT4 蛋白) pathways in response to TLR4 (显示 TLR4 蛋白) activation.

  8. Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma (显示 PPARG 蛋白)), inhibiting adipogenesis and disrupting ERK (显示 EPHB2 蛋白) signaling.

  9. MEK1 is inhibited by phosphorylation at Thr (显示 TRH 蛋白)-292/286 by Cdk5 (显示 CDK5 蛋白), ERK (显示 EPHB2 蛋白), and Cdk1 (显示 CDK1 蛋白).

  10. The effect of Akt1 (显示 AKT1 蛋白) and Mek1 on extracellular matrix synthesis was reconciled through the activation of p70 S6-kinase (显示 PRKACB 蛋白).

Xenopus laevis Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. in FGFR1 (显示 FGFR1 蛋白) signalling JNK1 (显示 MAPK8 蛋白) phosphorylation depends on ERK2 (显示 MAPK1 蛋白)

  2. The data demonstrate that ERK (显示 MAPK1 蛋白) phosphorylation of UBF prevents DNA bending by its first two HMG (显示 SSRP1 蛋白) boxes, leading to a cooperative unfolding of the enhancesome

  3. We propose that Erk2 MAP kinase (显示 MAPK1 蛋白) phosphorylation of Vg1RBP (显示 IGF2BP3 蛋白) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.

Rabbit Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Extracellular signal-regulated kinase (ERK (显示 MAPK1 蛋白)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.

  2. KSR (显示 KSR1 蛋白) interacts with a regulatory Raf (显示 RAF1 蛋白) molecule in cis (显示 CISH 蛋白) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (显示 RAF1 蛋白) molecule in trans

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Data indicate that MEKK2 (显示 MAP3K2 蛋白) is required for the mekk1 (显示 MAP3K1 蛋白), mkk1 mkk2 (显示 MAP2K2 蛋白), and mpk4 (显示 MAPK4 蛋白) autoimmune phenotypes.

  2. Data suggest that the MEKK1 (显示 MAP3K1 蛋白)-MKK1/MKK2 (显示 MAP2K2 蛋白)-MPK4 (显示 MAPK4 蛋白) kinase cascade negatively regulates MEKK2 (显示 MAP3K2 蛋白) and activation of MEKK2 (显示 MAP3K2 蛋白) triggers SUMM2-mediated immune responses.

  3. miR (显示 MYLIP 蛋白)-1826 plays an important role as tumor suppressor via CTNNB1 (显示 CTNNB1 蛋白)/MEK1/VEGFC (显示 VEGFC 蛋白) downregulation in bladder cancer.

  4. ETS1 (显示 ETS1 蛋白) is probably mediating high CIP2A (显示 KIAA1524 蛋白) expression in human cancers with increased EGFR (显示 EGFR 蛋白)-MEK1/2-ERK (显示 MAPK1 蛋白) pathway activity

  5. An analysis of the interation of MEKK1 (显示 MAP3K1 蛋白) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.

  6. This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.

  7. These results suggest that the formation of SUMO-1 (显示 SUMO1 蛋白) foci is regulated by the MEK-ERK (显示 MAPK1 蛋白) pathway and may induce apoptosis.

  8. AtMEK1 is a crucial mediator in plant stress signal transduction.

  9. double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (显示 MAP2K2 蛋白) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (显示 MAP3K1 蛋白) and mpk4 (显示 MAPK4 蛋白) mutants

  10. Activation of MPK4 (显示 MAPK4 蛋白) by flg22 is impaired in the mkk1 mkk2 (显示 MAP2K2 蛋白) double mutants, suggesting that MKK1 and MKK2 (显示 MAP2K2 蛋白) function together with MPK4 (显示 MAPK4 蛋白) and MEKK1 (显示 MAP3K1 蛋白) in a MAP kinase (显示 MAPK1 蛋白) cascade to negatively regulate innate immune responses in plants.

蛋白简介MAP2K1

蛋白简介

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Alternative names and synonyms associated with MAP2K1

  • mitogen activated protein kinase kinase 1 (Map2k1)
  • mitogen-activated protein kinase kinase 1 (MAP2K1)
  • mitogen-activated protein kinase kinase 1 (Map2k1)
  • mitogen-activated protein kinase kinase 1 (map2k1)
  • mitogen-activated protein kinase kinase 1 (MEK1)
  • ATMEK1 蛋白
  • CFC3 蛋白
  • F20B18.180 蛋白
  • F20B18_180 蛋白
  • MAP kinase/ ERK kinase 1 蛋白
  • MAPKK1 蛋白
  • MEK 蛋白
  • mek-2 蛋白
  • MEK1 蛋白
  • MEKK1 蛋白
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 蛋白
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 蛋白
  • MKK1 蛋白
  • NMAPKK 蛋白
  • Prkmk1 蛋白
  • si:ch211-242m18.2 蛋白
  • wu:fj56a12 蛋白
  • wu:fj61b01 蛋白
  • zgc:56557 蛋白

Protein level used designations for MAP2K1

ERK activator kinase 1 , MAP kinase kinase 1 , MAP kinase/Erk kinase 1 , MAPK/ERK kinase 1 , MAPKK 1 , dual specificity mitogen-activated protein kinase kinase 1 , mitogen-activated protein kinase kinase 1 , MEK 1 , protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) , dual specificity mitogen activated protein kinase kinase 1 , mitogen activated protein kinase kinase 1 , protein kinase, mitogen activated, kinase 1, p45 , MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2) , MEK1

GENE ID SPECIES
170851 Rattus norvegicus
5604 Homo sapiens
478347 Canis lupus familiaris
26395 Mus musculus
379991 Xenopus laevis
415549 Gallus gallus
533199 Bos taurus
406728 Danio rerio
100009316 Oryctolagus cuniculus
100233191 Sus scrofa
828713 Arabidopsis thaliana
450188 Pan troglodytes
MAP2K1 蛋白 (MAP2K1) 精选生产商
您还需要查找其他产品吗?