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High MEK1 expression is associated with liver cancer.
The BRAF/MAP2K1-mut LCH cells had a more immature state than BRAF/MAP2K1-wt LCH cells. Authors also found the BRAFV600E and MAP2K1 mutations were significantly associated with pERK expression.
There are no other biomarkers correlated with treatment responses following MEK1/2 inhibition.
High MEK1 expression is associated with neuroblastoma (显示 ARHGEF16 蛋白).
mutations in MAP2K1, which are frequently associated with neurological complications and intellectual disability, can be associated with a milder clinical and neurocognitive profile more typical of individuals with Noonan syndrome. Variability of expression may arise from a complex interplay between RAS/MAPK (显示 MAPK1 蛋白) pathway genotype, epigenetics, medical and obstetric factors, and environmental influences.
High MEK1 expression is associated with infant acute lymphoblastic leukemia.
Data show that combined therapy using HER2 (显示 ERBB2 蛋白) inhibitor and BRAF (显示 BRAF 蛋白)/MEK inhibitor presented more significant redifferentiation effect on papillary thyroid cancer cells harboring BRAFV600E than BRAF (显示 BRAF 蛋白)/MEK inhibitor alone.
MEK1 is constitutively and mainly phosphorylated at the Thr (显示 TRH 蛋白)-292, Ser (显示 SIGLEC1 蛋白)-298, Thr (显示 TRH 蛋白)-386, and Thr (显示 TRH 蛋白)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (显示 TRH 蛋白)-292, Ser (显示 SIGLEC1 蛋白)-298, Thr (显示 TRH 蛋白)-386, and Thr (显示 TRH 蛋白)-388 residues vary widely during activation and deactivation of the MAPK (显示 MAPK1 蛋白) pathway.
TNFRSF14 (显示 TNFRSF14 蛋白) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.
There was no statistically significant association between BRAF (显示 BRAF 蛋白) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.
data suggest that, although short-term suppression of Mek1/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Cdk5 (显示 CDK5 蛋白) may play an important role in endoplasmic reticulum stress induced podocyte apoptosis through MEKK1/JNK (显示 MAPK8 蛋白) pathway in diabetic nephropathy.
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
High MEK1 expression is associated with Melanoma Metastasis.
cartilage-specific inactivation of miR322 in mice linked the loss of miR (显示 MLXIP 蛋白)-322 to decreased MEK1 levels and to increased RAF (显示 RAF1 蛋白)/MEK (显示 MDK 蛋白)/ERK (显示 EPHB2 蛋白) pathway activation.
fluid shear stress induces autocrine TGF-beta (显示 TGFB1 蛋白)/ALK5 (显示 TGFBR1 蛋白)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.
Lgr4 (显示 LGR4 蛋白) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) pathways.
FGF2 (显示 FGF2 蛋白) is an extracellular inducer of COUP-TFII (显示 NR2F2 蛋白) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (显示 NR2F2 蛋白) expression prior to the onset of osteogenic differentiation
REDD1 (显示 DDIT4 蛋白) is required for normal insulin (显示 INS 蛋白)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (显示 DDIT4 蛋白), and mTOR (显示 FRAP1 蛋白)
blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (显示 LEPR 蛋白) mice
in FGFR1 (显示 FGFR1 蛋白) signalling JNK1 (显示 MAPK8 蛋白) phosphorylation depends on ERK2 (显示 MAPK1 蛋白)
The data demonstrate that ERK (显示 MAPK1 蛋白) phosphorylation of UBF prevents DNA bending by its first two HMG (显示 SSRP1 蛋白) boxes, leading to a cooperative unfolding of the enhancesome
We propose that Erk2 MAP kinase (显示 MAPK1 蛋白) phosphorylation of Vg1RBP (显示 IGF2BP3 蛋白) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.
Extracellular signal-regulated kinase (ERK (显示 MAPK1 蛋白)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.
KSR (显示 KSR1 蛋白) interacts with a regulatory Raf (显示 RAF1 蛋白) molecule in cis (显示 CISH 蛋白) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (显示 RAF1 蛋白) molecule in trans
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Genetic and biochemical evidences not only show that MEK1-MPK6 (显示 MAPK6 蛋白) cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1-MPK6 (显示 MAPK6 蛋白) cascade functions via working downstream of H2O2 and upstream of NO.
Data indicate that MEKK2 (显示 MAP3K2 蛋白) is required for the mekk1 (显示 MAP3K1 蛋白), mkk1 mkk2 (显示 MAP2K2 蛋白), and mpk4 (显示 MAPK4 蛋白) autoimmune phenotypes.
Data suggest that the MEKK1 (显示 MAP3K1 蛋白)-MKK1/MKK2 (显示 MAP2K2 蛋白)-MPK4 (显示 MAPK4 蛋白) kinase cascade negatively regulates MEKK2 (显示 MAP3K2 蛋白) and activation of MEKK2 (显示 MAP3K2 蛋白) triggers SUMM2-mediated immune responses.
miR (显示 MYLIP 蛋白)-1826 plays an important role as tumor suppressor via CTNNB1 (显示 CTNNB1 蛋白)/MEK1/VEGFC (显示 VEGFC 蛋白) downregulation in bladder cancer.
ETS1 (显示 ETS1 蛋白) is probably mediating high CIP2A (显示 KIAA1524 蛋白) expression in human cancers with increased EGFR (显示 EGFR 蛋白)-MEK1/2-ERK (显示 MAPK1 蛋白) pathway activity
An analysis of the interation of MEKK1 (显示 MAP3K1 蛋白) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.
These results suggest that the formation of SUMO-1 (显示 SUMO1 蛋白) foci is regulated by the MEK-ERK (显示 MAPK1 蛋白) pathway and may induce apoptosis.
AtMEK1 is a crucial mediator in plant stress signal transduction.
double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (显示 MAP2K2 蛋白) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (显示 MAP3K1 蛋白) and mpk4 (显示 MAPK4 蛋白) mutants
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
ERK activator kinase 1
, MAP kinase kinase 1
, MAP kinase/Erk kinase 1
, MAPK/ERK kinase 1
, MAPKK 1
, dual specificity mitogen-activated protein kinase kinase 1
, mitogen-activated protein kinase kinase 1
, MEK 1
, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
, dual specificity mitogen activated protein kinase kinase 1
, mitogen activated protein kinase kinase 1
, protein kinase, mitogen activated, kinase 1, p45
, MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2)