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Human MAP2K1 ELISA Kit for Sandwich ELISA - ABIN419235
El-Ansary, Hassan, Qasem, Das: Identification of Biomarkers of Impaired Sensory Profiles among Autistic Patients. in PLoS ONE 2016
Rat (Rattus) MAP2K1 ELISA Kit for Sandwich ELISA - ABIN433773
Du, Wang, Wang: Role of RhoA/MERK1/ERK1/2/iNOS signaling in ocular ischemic syndrome. in Graefe's archive for clinical and experimental ophthalmology 2016
High MEK1 expression is associated with neuroblastoma (显示 ARHGEF16 ELISA试剂盒).
mutations in MAP2K1, which are frequently associated with neurological complications and intellectual disability, can be associated with a milder clinical and neurocognitive profile more typical of individuals with Noonan syndrome. Variability of expression may arise from a complex interplay between RAS/MAPK (显示 MAPK1 ELISA试剂盒) pathway genotype, epigenetics, medical and obstetric factors, and environmental influences.
High MEK1 expression is associated with infant acute lymphoblastic leukemia.
Data show that combined therapy using HER2 (显示 ERBB2 ELISA试剂盒) inhibitor and BRAF (显示 BRAF ELISA试剂盒)/MEK inhibitor presented more significant redifferentiation effect on papillary thyroid cancer cells harboring BRAFV600E than BRAF (显示 BRAF ELISA试剂盒)/MEK inhibitor alone.
MEK1 is constitutively and mainly phosphorylated at the Thr (显示 TRH ELISA试剂盒)-292, Ser (显示 SIGLEC1 ELISA试剂盒)-298, Thr (显示 TRH ELISA试剂盒)-386, and Thr (显示 TRH ELISA试剂盒)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (显示 TRH ELISA试剂盒)-292, Ser (显示 SIGLEC1 ELISA试剂盒)-298, Thr (显示 TRH ELISA试剂盒)-386, and Thr (显示 TRH ELISA试剂盒)-388 residues vary widely during activation and deactivation of the MAPK (显示 MAPK1 ELISA试剂盒) pathway.
TNFRSF14 (显示 TNFRSF14 ELISA试剂盒) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.
There was no statistically significant association between BRAF (显示 BRAF ELISA试剂盒) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.
High MEK1 expression is associated with inflammation.
Lgr4 (显示 LGR4 ELISA试剂盒) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) pathways.
somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation
Cdk5 (显示 CDK5 ELISA试剂盒) may play an important role in endoplasmic reticulum stress induced podocyte apoptosis through MEKK1/JNK (显示 MAPK8 ELISA试剂盒) pathway in diabetic nephropathy.
Erk5 (显示 MAPK7 ELISA试剂盒) MAP kinase (显示 MAPK1 ELISA试剂盒) is activated in response to PDGF (显示 PDGFA ELISA试剂盒)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (显示 MAP3K2 ELISA试剂盒), Mek1/2, Mek5 (显示 MAP2K5 ELISA试剂盒), PI3-kinase (显示 PIK3CA ELISA试剂盒) and protein kinase C (PKC (显示 PKC ELISA试剂盒)).
High MEK1 expression is associated with Melanoma Metastasis.
cartilage-specific inactivation of miR322 in mice linked the loss of miR (显示 MLXIP ELISA试剂盒)-322 to decreased MEK1 levels and to increased RAF (显示 RAF1 ELISA试剂盒)/MEK (显示 MDK ELISA试剂盒)/ERK (显示 EPHB2 ELISA试剂盒) pathway activation.
fluid shear stress induces autocrine TGF-beta (显示 TGFB1 ELISA试剂盒)/ALK5 (显示 TGFBR1 ELISA试剂盒)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.
FGF2 (显示 FGF2 ELISA试剂盒) is an extracellular inducer of COUP-TFII (显示 NR2F2 ELISA试剂盒) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (显示 NR2F2 ELISA试剂盒) expression prior to the onset of osteogenic differentiation
REDD1 (显示 DDIT4 ELISA试剂盒) is required for normal insulin (显示 INS ELISA试剂盒)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (显示 DDIT4 ELISA试剂盒), and mTOR (显示 FRAP1 ELISA试剂盒)
blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (显示 LEPR ELISA试剂盒) mice
MEK1 and MEK2 (显示 MAP2K2 ELISA试剂盒) can substitute for each other but a minimum amount of MEK (显示 MDK ELISA试剂盒) is critical for placenta development and embryo survival
in FGFR1 (显示 FGFR1 ELISA试剂盒) signalling JNK1 (显示 MAPK8 ELISA试剂盒) phosphorylation depends on ERK2 (显示 MAPK1 ELISA试剂盒)
The data demonstrate that ERK (显示 MAPK1 ELISA试剂盒) phosphorylation of UBF prevents DNA bending by its first two HMG (显示 SSRP1 ELISA试剂盒) boxes, leading to a cooperative unfolding of the enhancesome
We propose that Erk2 MAP kinase (显示 MAPK1 ELISA试剂盒) phosphorylation of Vg1RBP (显示 IGF2BP3 ELISA试剂盒) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.
Extracellular signal-regulated kinase (ERK (显示 MAPK1 ELISA试剂盒)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.
KSR (显示 KSR1 ELISA试剂盒) interacts with a regulatory Raf (显示 RAF1 ELISA试剂盒) molecule in cis (显示 CISH ELISA试剂盒) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (显示 RAF1 ELISA试剂盒) molecule in trans
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Data indicate that MEKK2 (显示 MAP3K2 ELISA试剂盒) is required for the mekk1 (显示 MAP3K1 ELISA试剂盒), mkk1 mkk2 (显示 MAP2K2 ELISA试剂盒), and mpk4 (显示 MAPK4 ELISA试剂盒) autoimmune phenotypes.
Data suggest that the MEKK1 (显示 MAP3K1 ELISA试剂盒)-MKK1/MKK2 (显示 MAP2K2 ELISA试剂盒)-MPK4 (显示 MAPK4 ELISA试剂盒) kinase cascade negatively regulates MEKK2 (显示 MAP3K2 ELISA试剂盒) and activation of MEKK2 (显示 MAP3K2 ELISA试剂盒) triggers SUMM2-mediated immune responses.
miR (显示 MYLIP ELISA试剂盒)-1826 plays an important role as tumor suppressor via CTNNB1 (显示 CTNNB1 ELISA试剂盒)/MEK1/VEGFC (显示 VEGFC ELISA试剂盒) downregulation in bladder cancer.
ETS1 (显示 ETS1 ELISA试剂盒) is probably mediating high CIP2A (显示 KIAA1524 ELISA试剂盒) expression in human cancers with increased EGFR (显示 EGFR ELISA试剂盒)-MEK1/2-ERK (显示 MAPK1 ELISA试剂盒) pathway activity
An analysis of the interation of MEKK1 (显示 MAP3K1 ELISA试剂盒) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.
These results suggest that the formation of SUMO-1 (显示 SUMO1 ELISA试剂盒) foci is regulated by the MEK-ERK (显示 MAPK1 ELISA试剂盒) pathway and may induce apoptosis.
AtMEK1 is a crucial mediator in plant stress signal transduction.
double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (显示 MAP2K2 ELISA试剂盒) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (显示 MAP3K1 ELISA试剂盒) and mpk4 (显示 MAPK4 ELISA试剂盒) mutants
Activation of MPK4 (显示 MAPK4 ELISA试剂盒) by flg22 is impaired in the mkk1 mkk2 (显示 MAP2K2 ELISA试剂盒) double mutants, suggesting that MKK1 and MKK2 (显示 MAP2K2 ELISA试剂盒) function together with MPK4 (显示 MAPK4 ELISA试剂盒) and MEKK1 (显示 MAP3K1 ELISA试剂盒) in a MAP kinase (显示 MAPK1 ELISA试剂盒) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
ERK activator kinase 1
, MAP kinase kinase 1
, MAP kinase/Erk kinase 1
, MAPK/ERK kinase 1
, MAPKK 1
, dual specificity mitogen-activated protein kinase kinase 1
, mitogen-activated protein kinase kinase 1
, MEK 1
, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
, dual specificity mitogen activated protein kinase kinase 1
, mitogen activated protein kinase kinase 1
, protein kinase, mitogen activated, kinase 1, p45
, MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2)