anti-MAP2K1 (MAP2K1) 抗体产品概述

Full name:
anti-Mitogen-Activated Protein Kinase Kinase 1 抗体 (MAP2K1)
在www.antibodies-online.cn可供646 Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) 抗体的32不同的供货商。 再加上,我们可以发MAP2K1 试剂盒 (32)MAP2K1 蛋白 (26)和数多这个蛋白质的别的产品。 总共744 MAP2K1产品已列进来了。
别名:
ATMEK1, CFC3, F20B18.180, F20B18_180, MAP kinase/ ERK kinase 1, MAPKK1, MEK, mek-2, MEK1, MEKK1, MITOGEN ACTIVATED PROTEIN KINASE KINASE, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1, MKK1, NMAPKK, Prkmk1, si:ch211-242m18.2, wu:fj56a12, wu:fj61b01, zgc:56557

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引用最多的anti-MAP2K1 抗体

  1. Human Monoclonal MAP2K1 Primary Antibody for IP, WB - ABIN2853620 : Riesmeier, Willmitzer, Frommer: Evidence for an essential role of the sucrose transporter in phloem loading and assimilate partitioning. in The EMBO journal 1994 (PubMed)
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  2. Chicken Monoclonal MAP2K1 Primary Antibody for BI, IP - ABIN967762 : Aplin, Stewart, Assoian, Juliano: Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. in The Journal of cell biology 2001 (PubMed)
    Show all 5 references for 967762

  3. Human Polyclonal MAP2K1 Primary Antibody for EIA, IHC (p) - ABIN358157 : Ohren, Chen, Pavlovsky, Whitehead, Zhang, Kuffa, Yan, McConnell, Spessard, Banotai, Mueller, Delaney, Omer, Sebolt-Leopold, Dudley, Leung, Flamme, Warmus, Kaufman, Barrett, Tecle, Hasemann: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. in Nature structural & molecular biology 2004 (PubMed)
    Show all 5 references for 358157

  4. Human Polyclonal MAP2K1 Primary Antibody for IHC (p), WB - ABIN1881525 : Zheng, Fiumara, Li, Georgakis, Snell, Younes, Vauthey, Carbone, Younes: MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival. in Blood 2003 (PubMed)
    Show all 5 references for 1881525

  5. Human Polyclonal MAP2K1 Primary Antibody for EIA - ABIN358538 : Naegele, Morley: Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress. in The Journal of biological chemistry 2004 (PubMed)
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  6. Human Monoclonal MAP2K1 Primary Antibody for WB - ABIN967599 : Eblen, Slack, Weber, Catling: Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. in Molecular and cellular biology 2002 (PubMed)
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  7. Human Polyclonal MAP2K1 Primary Antibody for IHC (p), WB - ABIN197388 : Zebisch, Staber, Delavar, Bodner, Hiden, Fischereder, Janakiraman, Linkesch, Auner, Emberger, Windpassinger, Schimek, Hoefler, Troppmair, Sill: Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia. in Cancer research 2006 (PubMed)
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  8. Human Polyclonal MAP2K1 Primary Antibody for WB - ABIN197066 : Burroughs, Oh, Barrett, DiAugustine et al.: Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible ... in Molecular cancer research : MCR 2003 (PubMed)
    Show all 2 references for 197066

  9. Human Polyclonal MAP2K1 Primary Antibody for IHC (p), WB - ABIN196944 : Shen, Ouyang, Qu, Alonso, Sperzel, Mustelin, Kaplan, Feng: Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. in Molecular and cellular biology 2002 (PubMed)
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更多抗MAP2K1的相互作用对抗体

Human Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Data show that combined therapy using HER2 (显示 ERBB2 抗体) inhibitor and BRAF (显示 BRAF 抗体)/MEK inhibitor presented more significant redifferentiation effect on papillary thyroid cancer cells harboring BRAFV600E than BRAF (显示 BRAF 抗体)/MEK inhibitor alone.

  2. MEK1 is constitutively and mainly phosphorylated at the Thr (显示 TRH 抗体)-292, Ser (显示 SIGLEC1 抗体)-298, Thr (显示 TRH 抗体)-386, and Thr (显示 TRH 抗体)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (显示 TRH 抗体)-292, Ser (显示 SIGLEC1 抗体)-298, Thr (显示 TRH 抗体)-386, and Thr (显示 TRH 抗体)-388 residues vary widely during activation and deactivation of the MAPK (显示 MAPK1 抗体) pathway.

  3. TNFRSF14 (显示 TNFRSF14 抗体) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.

  4. There was no statistically significant association between BRAF (显示 BRAF 抗体) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.

  5. High MEK1 expression is associated with inflammation.

  6. Lgr4 (显示 LGR4 抗体) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 (显示 MAPK1/3 抗体) and Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) pathways.

  7. somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation

  8. MEK1 mutation is associated with central nervous system metastases of non-small cell lung cancer.

  9. The MAP2K1 mutation analysis of three hairy cell leukemia cases, one hairy cell leukemia-variant case, and three splenic marginal zone lymphoma cases revealed negative results.

  10. Data show that mitogen-activated protein kinase (显示 MAPK1 抗体) kinases MEK1/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. fluid shear stress induces autocrine TGF-beta (显示 TGFB1 抗体)/ALK5 (显示 TGFBR1 抗体)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.

  2. Lgr4 (显示 LGR4 抗体) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 (显示 MAPK1/3 抗体) and Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) pathways.

  3. FGF2 (显示 FGF2 抗体) is an extracellular inducer of COUP-TFII (显示 NR2F2 抗体) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (显示 NR2F2 抗体) expression prior to the onset of osteogenic differentiation

  4. REDD1 (显示 DDIT4 抗体) is required for normal insulin (显示 INS 抗体)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (显示 DDIT4 抗体), and mTOR (显示 FRAP1 抗体)

  5. blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (显示 LEPR 抗体) mice

  6. MEK1 and MEK2 (显示 MAP2K2 抗体) can substitute for each other but a minimum amount of MEK (显示 MDK 抗体) is critical for placenta development and embryo survival

  7. Aberrant phosphorylation of AKT (显示 AKT1 抗体) and MEK (显示 MDK 抗体) signalling pathways was identified in cells carrying mutant huntingtin (显示 HTT 抗体).

  8. An essential function for MEK1 in macrophages in regulating the ERK1/2 (显示 MAPK1/3 抗体) and STAT4 (显示 STAT4 抗体) pathways in response to TLR4 (显示 TLR4 抗体) activation.

  9. Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma (显示 PPARG 抗体)), inhibiting adipogenesis and disrupting ERK (显示 EPHB2 抗体) signaling.

  10. MEK1 is inhibited by phosphorylation at Thr (显示 TRH 抗体)-292/286 by Cdk5 (显示 CDK5 抗体), ERK (显示 EPHB2 抗体), and Cdk1 (显示 CDK1 抗体).

Xenopus laevis Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. in FGFR1 (显示 FGFR1 抗体) signalling JNK1 (显示 MAPK8 抗体) phosphorylation depends on ERK2 (显示 MAPK1 抗体)

  2. The data demonstrate that ERK (显示 MAPK1 抗体) phosphorylation of UBF prevents DNA bending by its first two HMG (显示 SSRP1 抗体) boxes, leading to a cooperative unfolding of the enhancesome

  3. We propose that Erk2 MAP kinase (显示 MAPK1 抗体) phosphorylation of Vg1RBP (显示 IGF2BP3 抗体) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.

Rabbit Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Extracellular signal-regulated kinase (ERK (显示 MAPK1 抗体)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.

  2. KSR (显示 KSR1 抗体) interacts with a regulatory Raf (显示 RAF1 抗体) molecule in cis (显示 CISH 抗体) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (显示 RAF1 抗体) molecule in trans

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) interaction partners

  1. Data indicate that MEKK2 (显示 MAP3K2 抗体) is required for the mekk1 (显示 MAP3K1 抗体), mkk1 mkk2 (显示 MAP2K2 抗体), and mpk4 (显示 MAPK4 抗体) autoimmune phenotypes.

  2. Data suggest that the MEKK1 (显示 MAP3K1 抗体)-MKK1/MKK2 (显示 MAP2K2 抗体)-MPK4 (显示 MAPK4 抗体) kinase cascade negatively regulates MEKK2 (显示 MAP3K2 抗体) and activation of MEKK2 (显示 MAP3K2 抗体) triggers SUMM2-mediated immune responses.

  3. miR (显示 MYLIP 抗体)-1826 plays an important role as tumor suppressor via CTNNB1 (显示 CTNNB1 抗体)/MEK1/VEGFC (显示 VEGFC 抗体) downregulation in bladder cancer.

  4. ETS1 (显示 ETS1 抗体) is probably mediating high CIP2A (显示 KIAA1524 抗体) expression in human cancers with increased EGFR (显示 EGFR 抗体)-MEK1/2-ERK (显示 MAPK1 抗体) pathway activity

  5. An analysis of the interation of MEKK1 (显示 MAP3K1 抗体) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.

  6. This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.

  7. These results suggest that the formation of SUMO-1 (显示 SUMO1 抗体) foci is regulated by the MEK-ERK (显示 MAPK1 抗体) pathway and may induce apoptosis.

  8. AtMEK1 is a crucial mediator in plant stress signal transduction.

  9. double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (显示 MAP2K2 抗体) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (显示 MAP3K1 抗体) and mpk4 (显示 MAPK4 抗体) mutants

  10. Activation of MPK4 (显示 MAPK4 抗体) by flg22 is impaired in the mkk1 mkk2 (显示 MAP2K2 抗体) double mutants, suggesting that MKK1 and MKK2 (显示 MAP2K2 抗体) function together with MPK4 (显示 MAPK4 抗体) and MEKK1 (显示 MAP3K1 抗体) in a MAP kinase (显示 MAPK1 抗体) cascade to negatively regulate innate immune responses in plants.

MAP2K1 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Alternative names and synonyms associated with MAP2K1

  • mitogen activated protein kinase kinase 1 (Map2k1) 抗体
  • mitogen-activated protein kinase kinase 1 (MAP2K1) 抗体
  • mitogen-activated protein kinase kinase 1 (Map2k1) 抗体
  • mitogen-activated protein kinase kinase 1 (map2k1) 抗体
  • mitogen-activated protein kinase kinase 1 (MEK1) 抗体
  • ATMEK1 抗体
  • CFC3 抗体
  • F20B18.180 抗体
  • F20B18_180 抗体
  • MAP kinase/ ERK kinase 1 抗体
  • MAPKK1 抗体
  • MEK 抗体
  • mek-2 抗体
  • MEK1 抗体
  • MEKK1 抗体
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 抗体
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 抗体
  • MKK1 抗体
  • NMAPKK 抗体
  • Prkmk1 抗体
  • si:ch211-242m18.2 抗体
  • wu:fj56a12 抗体
  • wu:fj61b01 抗体
  • zgc:56557 抗体

Protein level used designations for MAP2K1

ERK activator kinase 1 , MAP kinase kinase 1 , MAP kinase/Erk kinase 1 , MAPK/ERK kinase 1 , MAPKK 1 , dual specificity mitogen-activated protein kinase kinase 1 , mitogen-activated protein kinase kinase 1 , MEK 1 , protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) , dual specificity mitogen activated protein kinase kinase 1 , mitogen activated protein kinase kinase 1 , protein kinase, mitogen activated, kinase 1, p45 , MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2) , MEK1

GENE ID SPECIES
170851 Rattus norvegicus
5604 Homo sapiens
478347 Canis lupus familiaris
26395 Mus musculus
379991 Xenopus laevis
415549 Gallus gallus
533199 Bos taurus
406728 Danio rerio
100009316 Oryctolagus cuniculus
100233191 Sus scrofa
828713 Arabidopsis thaliana
450188 Pan troglodytes
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