JNK 蛋白 (MAPK8)产品概述

Full name:
Mitogen-Activated Protein Kinase 8 蛋白 (MAPK8)
在www.antibodies-online.cn可供30 Mitogen-Activated Protein Kinase 8 (MAPK8) 蛋白的10不同的供货商。 再加上,我们可以发JNK 抗体 (432)JNK 试剂盒 (27)和数多这个蛋白质的别的产品。 总共523 JNK产品已列进来了。
AI849689, Bsk, BSK/DJNK, c-Jun, CG5680, D-JNK, D-junk, DBSK/JNK, dJNK, DJNK/bsk, Dmel\\CG5680, jnk, JNK-46, JNK/SAPK, jnk1, JNK1A2, JNK21B1/2, Junk, mapk8, Prkm8, sapk1, SAPK1c, SAPKa, T10F20.15, zgc:112379
列出全部蛋白 基因 基因ID UniProt
MAPK8 5599 P45983
MAPK8 26419 Q91Y86
MAPK8 116554 P49185


按照种类JNK 蛋白 (MAPK8)


引用最多的JNK 蛋白

  1. Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN2003397 : Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for 2003397

  2. Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN593493 : Sury, McShane, Hernandez-Miranda, Birchmeier, Selbach et al.: Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU ... in Molecular & cellular proteomics : MCP 2015 (PubMed)

  3. Human JNK Protein expressed in Wheat germ - ABIN1310303 : Prause, Christensen, Billestrup, Mandrup-Poulsen: JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. in PLoS ONE 2014 (PubMed)


Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (显示 EGFR 蛋白)) pathway in the lateral epidermis for sustained dpp (显示 TGFb 蛋白) expression in the LE. Specifically, we demonstrate that Egfr (显示 EGFR 蛋白) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling

  2. n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing

  3. malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS (显示 ETS1 蛋白)-domain factor Ets21c and the nuclear receptor Ftz-F1 (显示 NR5A2 蛋白), all acting downstream of Jun-N-terminal kinase.

  4. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.

  5. ROS (显示 ROS1 蛋白)/JNK/p38 (显示 MAPK14 蛋白)/Upd (显示 UROD 蛋白) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  6. Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (显示 NOTCH1 蛋白)-Src (显示 SRC 蛋白) synergy.

  7. This study demonstrated that the mechanism by which Bsk (显示 FRK 蛋白) is required for pruning is through reducing the membrane levels of the adhesion molecule (显示 NCAM1 蛋白) Fasciclin II (显示 NCAM2 蛋白) (FasII)

  8. Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (显示 AMPH 蛋白)-PNP (显示 NP 蛋白)) and magnesium.

  9. PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.

  10. Data show that oxidative stress and neuroinflammation are intrinsic components of TDP-43 (显示 TARDBP 蛋白)-associated neurodegeneration and the balance between cytoprotective JNK and cytotoxic p38 (显示 MAPK14 蛋白) signaling dictates phenotypic outcome to TDP-43 (显示 TARDBP 蛋白) expression in Drosophila.

Human Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Taken together, our data demonstrate that JNK regulates triple-negative breast cancer (TNBC)tumorigenesis by promoting CSC phenotype through Notch1 (显示 NOTCH1 蛋白) signaling via activation of c-Jun (显示 JUN 蛋白) and indicate that JNK/c-Jun/Notch1 (显示 NOTCH1 蛋白) signaling is a potential therapeutic target for TNBC

  2. Here, the authors show that the CDK (显示 CDK4 蛋白) inhibitor p21 (CDKN1A (显示 CDKN1A 蛋白)) maintains the viability of DNA damage-induced senescent cells. Upon p21 (显示 CDKN1A 蛋白) knockdown, senescent cells acquired multiple DNA lesions that activated ataxia telangiectasia mutated (ATM (显示 ATM 蛋白)) and nuclear factor (NF)-kappaB (显示 NFKB1 蛋白) kinase, leading to decreased cell survival. NF-kappaB (显示 NFKB1 蛋白) activation induced TNF-alpha (显示 TNF 蛋白) secretion and JNK activation to mediate death of senescent cells in a...

  3. Results indicate that cordycepin promotes caveolin-1 (CAV1 (显示 CAV1 蛋白))upregulation to enhance c-jun N-terminal kinase (JNK)/forkhead box O3A (显示 FOXO3 蛋白) protein (Foxo3a (显示 FOXO3 蛋白)) signaling pathway activation, inducing apoptosis in lung cancer cells.

  4. The combination of 2-deoxyglucose (2-DG) and ABT-199 initiated cell death through the reduction of myeloid cell leukemia sequence 1 protein (Mcl-1 (显示 MCL1 蛋白)) expression and c-Jun N-terminal kinase 1 (JNK1) activation and subsequent Bcl-xL (显示 BCL2L1 蛋白) protein degradation.

  5. identified the c-Jun N-terminal kinase 1 (JNK1) as the kinase involved in the phosphorylation of NEIL1 (显示 NEIL1 蛋白)

  6. This study suggests that advanced glycation end products (AGEs) and activation of AGEs receptor could induce the proliferation of smooth muscle cells from Saphenous vein but not smooth muscle cells from internal thoracic arteryvia MAP kinase (显示 MAPK1 蛋白) pathway in diabetes mellitus.

  7. The increase in c-Jun N-terminal kinase (c-Jun) and specificity protein 1 (SP1 (显示 SP1 蛋白)) expressions was positively correlated with transforming growth factor beta 1 (TGFbeta1 (显示 TGFB1 蛋白)) in both high glucose-treated renal mesangial cells (HRMCs) and diabetic kidneys.

  8. JNK1 physically and functionally interacted with VDR (显示 CYP27B1 蛋白) and positively regulated VDR (显示 CYP27B1 蛋白) expression at transcriptional and translational levels, which influenced calcitriol-mediated inhibition of cancer cell proliferation.

  9. In conclusion, our findings revealed DIP2 as a novel effector downstream of Bsk (显示 FRK 蛋白) modulating the direction of axon projection.

  10. The release of infectious respiratory syncytial virus (RSV) virions from infected cells was significantly reduced by JNK1/2 siRNA knockdown, implicating JNK1/2 as a key host factor for RSV virus production.

Mouse (Murine) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Study examined whether JNK is present at the presynaptic site and its activity after presynaptic NMDA receptors stimulation; found that JNK, via the JBD domain, acts as a physiological effector on T-SNARE (显示 VTI1B 蛋白) proteins; data suggest that JNK-dependent phosphorylation of T-SNARE (显示 VTI1B 蛋白) proteins may have an important functional role in synaptic plasticity.

  2. JNK signaling, which is inversely correlated with WNT4 (显示 WNT4 蛋白), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin (显示 CDH1 蛋白) junctions between oocytes in mouse ovaries.

  3. It was concluded that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.

  4. JNK1 activation suppresses antifungal immunity in mice. JNK1-deficient mice had a significantly higher survival rate than wild-type control mice in response to Candida albicans infection, and the expression of JNK1 in hematopoietic innate immune cells was critical for this effect.

  5. activation of JNK in the endoplasmic reticulum stress response precedes activation of XBP1 (显示 XBP1 蛋白).

  6. Data suggest that single muscle immobilization induces a shift of myosin heavy chain (MHC) isoforms composition toward a faster contractile phenotype and decreases the polymorphic profile of single fibres, and that activation of p38 and JNK could be a potential mechanism involved in these contractile phenotype modifications during muscle immobilization.

  7. JNK/FoxO1 (显示 FOXO1 蛋白) is involved in the regulation of oxidative stress-induced (显示 SQSTM1 蛋白) cell apoptosis in MGCs

  8. apoE (显示 APOE 蛋白)(-/-) mouse carrying a visceral fat graft from obese dnJNK donors were protected against enhanced systemic inflammation and atherogenesis.

  9. These data provide evidence for involvement of the TNF-alpha (显示 TNF 蛋白)-JNK axis in extracellular matrix remodeling.

  10. Phosphorylation levels of P38 (显示 CRK 蛋白) and JNK in siRNA-TMEM16A (显示 ANO1 蛋白) group were lower than that of the Model group. Thus, TMEM16A (显示 ANO1 蛋白) is one of the critical components of a signal transduction pathway that links renal injury to podocyte apoptosis in DN.

Xenopus laevis Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (显示 CASP3 蛋白)-dependent Proteolysis of JNK1-2 and Bid (显示 BID 蛋白).

  2. JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (显示 GUSB 蛋白).

  3. Data show that the death pathway is independent of ERK (显示 MAPK1 蛋白) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (显示 CDK1 蛋白) and JNK.

Arabidopsis thaliana Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. study reports MPK8 connects protein phosphorylation, Ca(2 (显示 CA2 蛋白))+ and ROS (显示 ROS1 蛋白) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (显示 CA2 蛋白))+/CaMs and MAP kinase (显示 MAPK1 蛋白) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (显示 ROS1 蛋白) homeostasis

Zebrafish Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein

  2. P38 (显示 MAPK14 蛋白) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.

  3. A dorsalization pathway that is exerted by Axin (显示 AXIN1 蛋白)/JNK signaling and its inhibitor Aida (显示 AIDA 蛋白) during vertebrate embryogenesis, is defined.

  4. JNK-Mmp13 (显示 MMP13 蛋白) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Caenorhabditis elegans (C. elegans) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (显示 INS 蛋白)-IGF-1 (显示 IGF1 蛋白) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi

  2. JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.

  3. The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.

  4. the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (显示 MAPK1 蛋白) (MAPK (显示 MAPK1 蛋白)) signaling pathway, which is regulated by MLK-1 (显示 MAP3K9 蛋白) MAPK (显示 MAPK1 蛋白) kinase kinase (MAPKKK), MEK-1 (显示 MAP2K1 蛋白) MAPK (显示 MAPK1 蛋白) kinase (MAPKK), and KGB-1 (显示 KCNJ3 蛋白) JNK-like MAPK (显示 MAPK1 蛋白).

蛋白简介JNK (MAPK8)


The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with JNK (MAPK8)

  • basket (bsk)
  • mitogen-activated protein kinase 8 (MAPK8)
  • mitogen-activated protein kinase 8 (Mapk8)
  • mitogen-activated protein kinase 8 (mapk8)
  • mitogen-activated protein kinase 8 (ATMPK8)
  • mitogen-activated protein kinase 8b (mapk8b)
  • Protein JNK-1 (jnk-1)
  • AI849689 蛋白
  • Bsk 蛋白
  • BSK/DJNK 蛋白
  • c-Jun 蛋白
  • CG5680 蛋白
  • D-JNK 蛋白
  • D-junk 蛋白
  • DBSK/JNK 蛋白
  • dJNK 蛋白
  • DJNK/bsk 蛋白
  • Dmel\\CG5680 蛋白
  • jnk 蛋白
  • JNK-46 蛋白
  • JNK/SAPK 蛋白
  • jnk1 蛋白
  • JNK1A2 蛋白
  • JNK21B1/2 蛋白
  • Junk 蛋白
  • mapk8 蛋白
  • Prkm8 蛋白
  • sapk1 蛋白
  • SAPK1c 蛋白
  • SAPKa 蛋白
  • T10F20.15 蛋白
  • zgc:112379 蛋白

Protein level used designations for MAPK8

CG5680-PB , CG5680-PE , CG5680-PF , JNK , JUN kinase , Jun N-terminal kinase , Jun NH2-terminal kinase , Jun-N-terminal kinase , Jun-kinase , bsk-PB , bsk-PE , bsk-PF , c-Jun N-terminal kinase , c-Jun aminoterminal kinase , c-Jun-N-terminal kinase , drosophila JNK , JUN N-terminal kinase , MAP kinase 8 , c-Jun N-terminal kinase 1 , mitogen-activated protein kinase 8 isoform JNK1 alpha1 , mitogen-activated protein kinase 8 isoform JNK1 beta2 , stress-activated protein kinase 1 , stress-activated protein kinase 1c , JNK1 beta1 protein kinase , MAPK 8 , mitogen activated protein kinase 8 , protein kinase mitogen-activated 8 , stress-activated protein kinase JNK1 , SAPK gamma , c-jun NH2-terminal kinase , p54 gamma , jnk1a-1 , mitogen-activated protein kinase 8

44801 Drosophila melanogaster
5599 Homo sapiens
26419 Mus musculus
116554 Rattus norvegicus
379876 Xenopus laevis
838394 Arabidopsis thaliana
65236 Danio rerio
177460 Caenorhabditis elegans
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