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Noguchi, Naziruddin, Shimoda, Fujita, Chujo, Takita, Peng, Sugimoto, Itoh, Tamura, Olsen, Kobayashi, Onaca, Levy, Matsumoto: Comparison of fresh and cultured islets from human and porcine pancreata. in Transplantation proceedings 2010
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Human JNK ELISA Kit for Cell ELISA - ABIN1981833
Hinton, Henderson, Blanks, Rudnicka, Miller: Monoclonal antibodies react with neuronal subpopulations in the human nervous system. in The Journal of comparative neurology 1988
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Shintani, Hollingsworth, Wheelock, Johnson: Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. in Cancer research 2006
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aken together, these results reveal that inactivation of Rpd3 (显示 HDAC1 ELISA试剂盒) independently regulates JNK and Yki (显示 YAP1 ELISA试剂盒) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (显示 HDAC1 ELISA试剂盒) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (显示 JAK3 ELISA试剂盒)/STAT (显示 STAT1 ELISA试剂盒) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (显示 EGFR ELISA试剂盒)) pathway in the lateral epidermis for sustained dpp (显示 TGFb ELISA试剂盒) expression in the LE. Specifically, we demonstrate that Egfr (显示 EGFR ELISA试剂盒) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (显示 SCRIB ELISA试剂盒)) tumors requires bZIP protein Fos, the ETS (显示 ETS1 ELISA试剂盒)-domain factor Ets21c and the nuclear receptor Ftz-F1 (显示 NR5A2 ELISA试剂盒), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (显示 ROS1 ELISA试剂盒)/JNK/p38 (显示 MAPK14 ELISA试剂盒)/Upd (显示 UROD ELISA试剂盒) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (显示 NOTCH1 ELISA试剂盒)-Src (显示 SRC ELISA试剂盒) synergy.
This study demonstrated that the mechanism by which Bsk (显示 FRK ELISA试剂盒) is required for pruning is through reducing the membrane levels of the adhesion molecule (显示 NCAM1 ELISA试剂盒) Fasciclin II (显示 NCAM2 ELISA试剂盒) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (显示 AMPH ELISA试剂盒)-PNP (显示 NP ELISA试剂盒)) and magnesium.
ERK1 (显示 MAPK3 ELISA试剂盒) Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun (显示 JUN ELISA试剂盒) Activity and Cell Transformation.
TGM2 (显示 TGM2 ELISA试剂盒) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (显示 FOSB ELISA试剂盒)/JNK signaling pathways in cultured monocytes.
NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys (显示 LYZ ELISA试剂盒) 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7 (显示 MAP2K7 ELISA试剂盒), thus disrupting JNK phosphorylation and activation.
The surface immune molecule CD274 (显示 CD274 ELISA试剂盒) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (显示 CD274 ELISA试剂盒)/JNK/Cyclin D2 (显示 CCND2 ELISA试剂盒) pathway promotes the cell cycle entry of LIC.
These data implicate HTRA1 (显示 HTRA1 ELISA试剂盒) as a negative regulator of mesenchymal stem cell adipogenesis.
Our findings indicate that GADD45 (显示 GADD45A ELISA试剂盒) essentially suppresses the MKK7 (显示 MAP2K7 ELISA试剂盒)-JNK pathway and suggest that differentially expressed GADD45 (显示 GADD45A ELISA试剂盒) family members fine-tune stress-inducible JNK activity.
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
post-translational modification facilitates the mobilization of SIRT6 (显示 SIRT6 ELISA试剂盒) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (显示 PARP1 ELISA试剂盒)) to DNA break sites and for efficient repair of double-strand break.
PRDM5 (显示 PRDM5 ELISA试剂盒) promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression and strategies targeting PRDM5 (显示 PRDM5 ELISA试剂盒) may be promising for the therapy of melanoma.
This study showed that the induction level of IL-32 (显示 IL32 ELISA试剂盒) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (显示 IRF6 ELISA试剂盒)-induced IL-32 (显示 IL32 ELISA试剂盒) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (显示 TLR4 ELISA试剂盒)/JNK/AKT (显示 AKT1 ELISA试剂盒)/CREB (显示 CREB1 ELISA试剂盒) signaling pathway.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
transgenic mice overexpressing sPLA2 -IIA (显示 PLA2G2A ELISA试剂盒) keratinocytes showed enhanced activation of EGFR (显示 EGFR ELISA试剂盒) and JNK1/2 that led to c-Jun (显示 JUN ELISA试剂盒) activation.
p53 (显示 TP53 ELISA试剂盒) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
We crossed Ptf1a (显示 PTF1A ELISA试剂盒)(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a (显示 PTF1A ELISA试剂盒)(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 (显示 CCL20 ELISA试剂盒) secretion
BOC (显示 BOC ELISA试剂盒) interacts with ABL (显示 ABL1 ELISA试剂盒) and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
The authors have found that JNK signaling is required for proper vascular morphogenesis and the normal formation of collateral arteries in muscle.
JNK1-mediated NLRP3 (显示 NLRP3 ELISA试剂盒) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (显示 NLRP3 ELISA试剂盒) inflammasome activation.
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (显示 CASP3 ELISA试剂盒)-dependent Proteolysis of JNK1-2 and Bid (显示 BID ELISA试剂盒).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (显示 GUSB ELISA试剂盒).
Data show that the death pathway is independent of ERK (显示 MAPK1 ELISA试剂盒) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (显示 CDK1 ELISA试剂盒) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (显示 CA2 ELISA试剂盒))+ and ROS (显示 ROS1 ELISA试剂盒) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (显示 CA2 ELISA试剂盒))+/CaMs and MAP kinase (显示 MAPK1 ELISA试剂盒) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (显示 ROS1 ELISA试剂盒) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (显示 MAPK14 ELISA试剂盒) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (显示 AXIN1 ELISA试剂盒)/JNK signaling and its inhibitor Aida (显示 AIDA ELISA试剂盒) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (显示 MMP13 ELISA试剂盒) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (显示 INS ELISA试剂盒)-IGF-1 (显示 IGF1 ELISA试剂盒) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (显示 MAPK1 ELISA试剂盒) (MAPK (显示 MAPK1 ELISA试剂盒)) signaling pathway, which is regulated by MLK-1 MAPK (显示 MAPK1 ELISA试剂盒) kinase kinase (MAPKKK), MEK-1 (显示 MAP2K1 ELISA试剂盒) MAPK (显示 MAPK1 ELISA试剂盒) kinase (MAPKK), and KGB-1 (显示 KCNJ3 ELISA试剂盒) JNK-like MAPK (显示 MAPK1 ELISA试剂盒).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8