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OS-9 regulates the secretory transport of TRPV4 (显示 TRPV4 蛋白) and appears to protect TRPV4 (显示 TRPV4 蛋白) subunits from the precocious ubiquitination and ER-associated degradation.
Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1 (显示 SLC12A1 蛋白)) prior to glycosylation/processing.
The depletion of OS-9 in 3T3-L1 adipocytes impaired cell function in terms of triacylglycerol storage, and slightly influenced cell differentiation.
The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor (显示 CASR 蛋白).
OS-9 up-regulates occludin (显示 OCLN 蛋白) and claudin-1 (显示 CLDN7 蛋白) by activating the MAP kinase (MAPK (显示 MAPK1 蛋白)) pathway, and thus protects the epithelial barrier function of Caco-2 monolayer under hypoxia condition.
EDEM2 (显示 EDEM2 蛋白) and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog (显示 SHH 蛋白)
Unique regions mediate the interaction between OS-9 and GRP94 (显示 HSP90B1 蛋白).
It delivers mutant neuroserpin (显示 SERPINI1 蛋白) to ERAD by recognition of glycan side chains and provide the first in vivo proof of involvement of ERAD in degradation of mutant neuroserpin (显示 SERPINI1 蛋白).
long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha (显示 HIF1A 蛋白) in pancreatic ductal adenocarcinoma.
Data indicate that the interaction of OS-9 and XTP3-B with CD147(CG) was inhibited by mutations to conserved residues in their lectin domains.
OS-9 plays no direct functional role in HIF degradation since physical interaction of OS-9 with oxygen sensing HIF prolyl hydroxylases cannot occur in vivo due to their different subcellular localization
The OS-9 specifically recognizes Manalpha1,6Manalpha1,6Man residues on the processed C-arm through the continuous double tryptophan (WW) motif.
The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
amplified in osteosarcoma
, osteosarcoma amplified 9, endoplasmic reticulum associated protein
, protein OS-9
, osteosarcoma amplified 9
, amplified in osteosarcoma 9
, endoplasmic reticulum lectin 2
, erlectin 2