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The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 (显示 BUB1B ELISA试剂盒) and Bub3, for which the BubR1 (显示 BUB1B ELISA试剂盒) Gle2 (显示 RAE1 ELISA试剂盒) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 (显示 BUB1B ELISA试剂盒) and BUB3 by BUB1 (显示 BUB1 ELISA试剂盒) is dispensable for SAC (显示 ADCY10 ELISA试剂盒) activation
a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments
the mechanisms of BUB3 in mitotic checkpoint signaling
Data show sequential multisite regulation of the microtubule-associated protein KNL1 (显示 CASC5 ELISA试剂盒)-kinase-adaptor complex BUB1 (显示 BUB1 ELISA试剂盒)/BUB3 interaction.
Data indicate that cell cycle protein Bub3-mediated kinetochore recruitment of BubR1 (显示 BUB1B ELISA试剂盒) kinase enhances mitotic checkpoint signaling.
Results suggest that these USP7 (显示 USP7 ELISA试剂盒)-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC (显示 ADCY10 ELISA试剂盒)) component Bub3.
Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC (显示 ADCY10 ELISA试剂盒) kinase Bub1 (显示 BUB1 ELISA试剂盒). Crucially, they also cause a checkpoint defect, showing that recognition of phosphorylated targets by Bub3 is required for checkpoint signaling
Results showed that neither variants in BUB3 nor variants in MAD2L1 (显示 MAD2L1 ELISA试剂盒) caused any significant effect on the risk of breast cancer
Mutations in BUB1 (显示 BUB1 ELISA试剂盒) and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age.
Data show that Zfp207 binds to Bub3 to form a complex and maintains its protein level in oocytes, and that overexpression of Bub3 is able to partially rescue the occurrence of aneuploid eggs in Zfp207-depleted oocytes.
as a member of the spindle assembly checkpoint, Bub3 is required for regulation of both meiosis I and II, and is potentially involved in kinetochore-microtubule attachment in mammalian oocytes
Cenpa (显示 CENPA ELISA试剂盒), Cenpb (显示 CENPB ELISA试剂盒), and Bub3, but not Cenpc (显示 CENPC1 ELISA试剂盒), interacted with PARP-1 (显示 PARP1 ELISA试剂盒)
Haploinsufficiency of Bub3 causes a slight increase in chromosome instability but is not clearly associated with a noticeable rise in the probability of tumor formation.
subpopulation of dynein, containing the DYNLT3 (显示 DYNLT3 ELISA试剂盒) light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
BUB3 budding uninhibited by benzimidazoles 3 homolog
, budding uninhibited by benomyl
, budding uninhibited by benzimidazoles 3 homolog
, mitotic checkpoint component
, mitotic checkpoint protein BUB3
, WD repeat protein Bub3
, WD repeat type I transmembrane protein A72.5