anti-Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) 抗体产品概述

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anti-Protein Phosphatase 1, Catalytic Subunit, alpha Isoform 抗体 (PPP1CA)
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别名:
2310003C21Rik, 2900017D14Rik, AI427932, AU017636, dism2, MMPa-2, MPPa-1, PP-1A, PP1A, PP1alpha, PP2C-ALPHA, PP2CA, PP2Calpha, PPP1A, Ppp1c, wu:fc04c08, wu:fc09b07, wu:fc30g11, wu:fe05h08, zgc:85729

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引用最多的anti-Protein Phosphatase 1, Catalytic Subunit, alpha Isoform 抗体

  1. Human Monoclonal PPP1CA Primary Antibody for ELISA, WB - ABIN969360 : Chen, Kesler, Paschal, Balk: Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for 969360

  2. Human Monoclonal PPP1CA Primary Antibody for ELISA, WB - ABIN969359 : Luo, Peterson, Garcia, Coombs, Kofahl, Heinrich, Shabanowitz, Hunt, Yost, Virshup: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. in The EMBO journal 2007 (PubMed)
    Show all 2 references for 969359

  3. Human Monoclonal PPP1CA Primary Antibody for IF, WB - ABIN1108708 : Barker, Jones, da Cruz e Silva, Spurr, Sheer, Cohen: Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. in Genomics 1990 (PubMed)
    Show all 2 references for 1108708

  4. Human Monoclonal PPP1CA Primary Antibody for EIA, IHC (p) - ABIN238369 : Cohen: Protein phosphatase 1--targeted in many directions. in Journal of cell science 2002 (PubMed)
    Show all 2 references for 238369

  5. Human Polyclonal PPP1CA Primary Antibody for IHC, ELISA - ABIN1531470 : Song, Khanna, Lu, Lavin: Cloning and characterization of a human protein phosphatase 1-encoding cDNA. in Gene 1993 (PubMed)

  6. Cow (Bovine) Polyclonal PPP1CA Primary Antibody for WB - ABIN2787782 : Lesage, Beullens, Pedelini, Garcia-Gimeno, Waelkens, Sanz, Bollen: A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. in Biochemistry 2007 (PubMed)

更多抗Protein Phosphatase 1, Catalytic Subunit, alpha Isoform的相互作用对抗体

Mouse (Murine) Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) interaction partners

  1. Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (显示 GNB1 抗体) interact in quiescent platelets; then, Ppp1ca and Plcb3 (显示 PLCB3 抗体) interact during platelet aggregation; thus, Gnb1 (显示 GNB1 抗体) enlists Ppp1ca to modulate G protein-coupled receptor (显示 GPR34 抗体) signaling. (Ppp1ca = protein phosphatase 1 (显示 PPP1CB 抗体), catalytic subunit alpha; Gnb1 (显示 GNB1 抗体) = guanine nucleotide-binding protein (显示 TRIM23 抗体), subunit beta-1; Plcb3 (显示 PLCB3 抗体) = phospholipase C (显示 PLC 抗体), subunit beta-3)

  2. findings demonstrate a novel regulatory circuit in which STING and TBK1 (显示 TBK1 抗体) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (显示 PPM1A 抗体) dephosphorylates STING and TBK1 (显示 TBK1 抗体)

  3. the studies presented here position PPM1A (显示 PPM1A 抗体) as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  4. Ang (显示 ANG 抗体) IV functions via regulating the activity of PP1 (显示 PPP1CC 抗体)

  5. a nuclear envelope-localized mechanism of inactivating TGF-beta (显示 TGFB1 抗体) signaling in which MAN1 (显示 LEMD3 抗体) competes with transcription factors for binding to Smad2 (显示 SMAD2 抗体) and Smad3 (显示 SMAD3 抗体) and facilitates their dephosphorylation by PPM1A (显示 PPM1A 抗体).

  6. Although a non-myristoylated mutation (G2A (显示 GPR132 抗体)) of PPM1A (显示 PPM1A 抗体) and PPM1B (显示 PPM1B 抗体) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (显示 GRK4 抗体).

  7. we found that PPM1A (显示 PPM1A 抗体) mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A (显示 PPM1A 抗体) protein

  8. Cell surface expression of the major amyloid-beta peptide (Abeta (显示 APP 抗体))-degrading enzyme, neprilysin (显示 MME 抗体), depends on phosphorylation by mitogen-activated protein kinase (显示 MAPK1 抗体)/extracellular signal-regulated kinase kinase (MEK (显示 MDK 抗体)) and dephosphorylation by protein phosphatase 1a (显示 PPM1A 抗体).

  9. analysis of selective regulation of NR2B (显示 GRIN2B 抗体) by protein phosphatase-1 (显示 PPP1CB 抗体) for the control of the NMDA receptor in neuroprotection

  10. Protein phosphatase PPM1A (显示 PPM1A 抗体) regulates the nuclear export of Smad2 (显示 SMAD2 抗体)/3 through targeting nuclear exporter RanBP3 (显示 RANBP3 抗体).

Human Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) interaction partners

  1. establish PPM1A (显示 PPM1A 抗体) as a novel repressor of the SMAD3 (显示 SMAD3 抗体) pathway in renal fibrosis

  2. Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (显示 EIF2S1 抗体) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (显示 ATF4 抗体) expression. (eIF2a (显示 EIF2S1 抗体) = eukaryotic initiation factor-2alpha (显示 EIF2S1 抗体); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (显示 ATF4 抗体) = activating transcription factor 4 (显示 ATF4 抗体))

  3. Report a tumor-suppressive function of PPM1A (显示 PPM1A 抗体) and an independent relationship to Smad4 (显示 SMAD4 抗体) in pancreatic ductal adenocarcinoma.

  4. Protein phosphatase 1 (显示 PPP1CB 抗体) (PP1 (显示 PPA1 抗体)) forms stable complexes with PP1 (显示 PPA1 抗体)-interacting proteins (PIPs (显示 GPRASP1 抗体)) that guide the phosphatase throughout its life cycle and control its fate and function.

  5. The authors found that RNA recognition motif 1 (RRM1 (显示 RRM1 抗体)) in SRSF1 (显示 SRSF1 抗体) binds PP1 (显示 PPA1 抗体) and represses its catalytic function through an allosteric mechanism.

  6. this study shows a pivotal role for PP1 (显示 PPA1 抗体) in impeding IRF7 (显示 IRF7 抗体)-mediated IFN-alpha (显示 IFNA 抗体) production in host immune responses

  7. hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha (显示 PPM1A 抗体) between the active and inactive states

  8. In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A (显示 PPM1A 抗体); P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.

  9. The data support a model where Cdc7 (显示 CDC7 抗体) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (显示 CDC7 抗体) and PP1a/Cdk1 (显示 CDK1 抗体) to the regulation of once-per-cell cycle DNA replication in mammalian cells.

  10. These results indicate that PP1 (显示 PPA1 抗体) is recruited to the extracellular calcium-dependent E-cadherin (显示 CDH1 抗体)-catenin-PIP5K1a (显示 PIP5K1A 抗体) complex in the plasma membrane to activate PIP5K1a (显示 PIP5K1A 抗体), which is required for PLC (显示 HSPG2 抗体)-g1 activation leading to keratinocyte differentiation.

Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA)

  • protein phosphatase 1, catalytic subunit, alpha isozyme (ppp1ca) 抗体
  • protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA) 抗体
  • protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca) 抗体
  • protein phosphatase 1, catalytic subunit, alpha isoform a (ppp1caa) 抗体
  • protein phosphatase 1, catalytic subunit, alpha isozyme (Ppp1ca) 抗体
  • protein phosphatase 1, catalytic subunit, beta isozyme (Ppp1cb) 抗体
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a) 抗体
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A) 抗体
  • 2310003C21Rik 抗体
  • 2900017D14Rik 抗体
  • AI427932 抗体
  • AU017636 抗体
  • dism2 抗体
  • MMPa-2 抗体
  • MPPa-1 抗体
  • PP-1A 抗体
  • PP1A 抗体
  • PP1alpha 抗体
  • PP2C-ALPHA 抗体
  • PP2CA 抗体
  • PP2Calpha 抗体
  • PPP1A 抗体
  • Ppp1c 抗体
  • wu:fc04c08 抗体
  • wu:fc09b07 抗体
  • wu:fc30g11 抗体
  • wu:fe05h08 抗体
  • zgc:85729 抗体

Protein level used designations for PPP1CA

Protein phosphatase type 1 alpha, catalytic subunit , protein phosphatase 1, catalytic subunit, alpha isoform , PP-1A , serine/threonine-protein phosphatase PP1-alpha catalytic subunit , ppp1ca , protein phosphatase 1, catalytic subunit, alpha , serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit , protein phosphatase-1d , PP-1B , protein phosphatase 1, catalytic subunit, beta isoform , protein phosphatase-1a , serine/threonine-protein phosphatase PP1-beta catalytic subunit , Mpp alpha , PP2C-alpha , protein phosphatase 1A , protein phosphatase 2C isoform alpha , protein phosphatase IA , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , IA , protein phosphatase 2C alpha

GENE ID SPECIES
379914 Xenopus laevis
745709 Pan troglodytes
100059233 Equus caballus
100145598 Xenopus (Silurana) tropicalis
19045 Mus musculus
407980 Danio rerio
5499 Homo sapiens
24668 Rattus norvegicus
516175 Bos taurus
403609 Canis lupus familiaris
100009298 Oryctolagus cuniculus
25594 Rattus norvegicus
19042 Mus musculus
5494 Homo sapiens
281994 Bos taurus
100009431 Oryctolagus cuniculus
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