anti-CDK5RAP2 (CDK5RAP2) 抗体产品概述

Full name:
anti-CDK5 Regulatory Subunit Associated Protein 2 抗体 (CDK5RAP2)
在www.antibodies-online.cn可供30 CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) 抗体的9不同的供货商。 再加上,我们可以发CDK5RAP2 试剂盒 (1)和数多这个蛋白质的别的产品。 总共32 CDK5RAP2产品已列进来了。
2900018K03Rik, an, C48, Cep215, EGFL5, MCPH3, mKIAA1633
列出全部抗体 基因 基因ID UniProt
CDK5RAP2 55755 Q96SN8
CDK5RAP2 214444 Q8K389
CDK5RAP2 286919  



最受欢迎的抗anti-CDK5RAP2 (CDK5RAP2) 抗体


抗Human CDK5RAP2 抗体:

抗Mouse (Murine) CDK5RAP2 抗体:

抗Rat (Rattus) CDK5RAP2 抗体:

所有可销售的anti-CDK5RAP2 抗体


引用最多的anti-CDK5RAP2 抗体

  1. Human Polyclonal CDK5RAP2 Primary Antibody for IP, WB - ABIN152186 : Lizarraga, Margossian, Harris, Campagna, Han, Blevins, Mudbhary, Barker, Walsh, Fleming: Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. in Development (Cambridge, England) 2010 (PubMed)
    Show all 4 references for 152186

  2. Human Polyclonal CDK5RAP2 Primary Antibody for IHC, ELISA - ABIN1534333 : Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: DNA sequence and analysis of human chromosome 9. ... in Nature 2004 (PubMed)


Human CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) interaction partners

  1. results suggest that EB1 (显示 MAPRE2 抗体) cooperates with CDK5RAP2 and perhaps other SXIP-containing +TIPs in tracking growing microtubule tips.

  2. CDK5RAP2 may play a role in primary microcephaly and interacts with components of the Hippo signaling pathway

  3. Three siblings with isolated agenesis of corpus callosum carry compound heterozygous variants, p.[Gly94Arg];[Asn1232Ser], in CDK5RAP2 gene.

  4. stabilization of the centrosome-spindle pole interface by the CEP215-HSET (显示 KIFC1 抗体) complex could promote survival of cancer cells containing supernumerary centrosomes.

  5. mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms

  6. These results show that Cep169 targets microtubule tips and regulates stability of microtubules with CDK5RAP2.

  7. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM (显示 PCMT1 抗体)) preventing centriole separation following disengagement, PCNT (显示 PCNT 抗体) cleavage mediates Cep215 removal from core of the PCM (显示 PCMT1 抗体) to inhibit centriole disengagement and duplication

  8. LRRK1 regulates mitotic spindle orientation downstream of PLK1 (显示 PLK1 抗体) through CDK5RAP2-dependent centrosome maturation.

  9. The CEP215-pericentrin (显示 PCNT 抗体) interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis.

  10. DPP4, CDK5RAP2, and CCR6 are risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.

Mouse (Murine) CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) interaction partners

  1. mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms

  2. this study revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in part accountable for the lack of microcephaly in the mice.

  3. In Cdk5rap2-depleted neural embryonic stem cells there is an increase in cell death in differentiating cells.

  4. Mouse expression pattern of CDK5RAP2 is similar to that seen in humans and is in concordance with pathology suggested by neuroimaging studies in humans and mouse

  5. This study demonistrated that CDK5RAP2 is a key molecule that mediates functional interaction and is essential for centrosomal targeting of Aurora-A (显示 AURKA 抗体).

  6. These results indicate that CDK5RAP2 is required to maintain centriole engagement and cohesion, thereby restricting centriole replication.

  7. Cdk5rap2 is highly expressed in the neural progenitor pool and its loss results in a depletion of apical progenitors and increased cell-cycle exit leading to premature neuronal differentiation

  8. The an mutation is a genomic inversion of exon 4 of Cdk5rap2, resulting in an in-frame deletion of exon 4 from the mRNA. Cdk5rap2(an/an) neuronal precursors exit the cell cycle prematurely and many undergo apoptosis.

CDK5RAP2 抗原简介

Antigen Summary

This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CDK5RAP2

  • CDK5 regulatory subunit associated protein 2 (CDK5RAP2) 抗体
  • CDK5 regulatory subunit associated protein 2 (cdk5rap2) 抗体
  • CDK5 regulatory subunit associated protein 2 (Cdk5rap2) 抗体
  • 2900018K03Rik 抗体
  • an 抗体
  • C48 抗体
  • Cep215 抗体
  • EGFL5 抗体
  • MCPH3 抗体
  • mKIAA1633 抗体

Protein level used designations for CDK5RAP2

CDK5 regulatory subunit-associated protein 2 , EGF-like-domain, multiple 5 , CDK5 regulatory subunit associated protein 2 , CDK5 regulatory subunit-associated protein 2-like , CDK5 activator-binding protein C48 , centrosomal protein 215 kDa

508100 Bos taurus
612705 Canis lupus familiaris
771445 Gallus gallus
100156240 Sus scrofa
733952 Xenopus (Silurana) tropicalis
100071839 Equus caballus
100459050 Pongo abelii
55755 Homo sapiens
214444 Mus musculus
286919 Rattus norvegicus
464695 Pan troglodytes
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