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Findings suggest MALAT1 increases AKAP-9 expression by promoting SRPK1 (显示 SRPK1 ELISA试剂盒)-catalyzed SRSF1 (显示 SRSF1 ELISA试剂盒) phosphorylation in CRC (显示 CALR ELISA试剂盒) cells. These results reveal a novel molecular mechanism by which MALAT1 regulates AKAP-9 expression in CRC (显示 CALR ELISA试剂盒) cells.
AKAP9 gene harbors not only somatic frameshift mutations but also mutational ITH.
results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality.
Study suggests a role of rare missense variants at NRXN1 (显示 NRXN1 ELISA试剂盒) and AKAP9 in schizophrenia susceptibility, probably related to alteration of the excitatory/inhibitory synaptic balance, deserving further investigation
This study demonstrated that two rare AKAP9 variants( rs144662445 and rs149979685) are associated with Alzheimer's disease in African Americans.
AKAP9 has been identified as a Long QT Syndrome Type 1 modifying gene
data indicate that MALAT1 may promote CRC (显示 CALR ELISA试剂盒) tumor development via its target protein AKAP-9
A590T mutation in KCNQ1 (显示 KCNQ1 ELISA试剂盒) C-terminal helix D decreases KCNE1 (显示 KCNE1 ELISA试剂盒) channel trafficking and function but not Yotiao interaction.
AKAP (显示 AKAP1 ELISA试剂盒) proteins, most likely AKAP9, maintain the bronchial epithelial barrier by regulating the E-cadherin (显示 CDH1 ELISA试剂盒) expression at the cell membrane.
in heart, Yotiao brings together PKA, PP1 (显示 PPA1 ELISA试剂盒), PDE4D3, AC9 (显示 ADCY9 ELISA试剂盒), and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation.
AKAP9 and, by inference, the regulation of the microtubule network are critical for blood-testis barrier function and subsequent germ cell development during spermatogenesis
AKAP9 is dispensable for T cell priming and migration into tissues and lymph nodes, but is required for T cell retention in tissues.
We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain.
Overexpression of an AKAP450 fragment containing the CK1delta-binding site inhibits Golgi-derived microtubule nucleation, Golgi distribution of intraflagellar transport protein 20 homologue, and ciliogenesis.
Mutations in Akap9 disrupt Sertoli cell maturation, gap and tight junctions and localization of zona occluden-1 and connexin43 (显示 GJA1 ELISA试剂盒).
in heart, Yotiao brings together PKA, PP1 (显示 PPP1CC ELISA试剂盒), PDE4D3, AC9 (显示 ADCY9 ELISA试剂盒), and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation.
Expression of Akap9 in the mouse striatum is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (显示 UTS2R ELISA试剂盒) of Comt (catechol-O-methyltransferase (显示 COMT ELISA试剂盒)).
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.
A-kinase anchor protein 350 kDa
, A-kinase anchor protein 450 kDa
, A-kinase anchor protein 9
, AKAP 120-like protein
, AKAP9-BRAF fusion protein
, centrosome- and Golgi-localized PKN-associated protein
, kinase N-associated protein
, protein hyperion
, protein kinase A anchoring protein 9
, protein phosphatase 1, regulatory subunit 45
, protein yotiao
, protein kinase A-anchoring protein 9
, GABA-B receptor-interacting scaffolding protein
, hyperion protein, 419 kD isoform
, A kinase (PRKA) anchor protein (yotiao) 9
, a-kinase anchor protein 9
, a-kinase anchor protein 9-like
, A kinase (PRKA) anchor protein 9
, A-kinase anchoring protein AKAP120
, A-kinase anchor protein 120 kDa
, AKAP 120
, myocyte A kinase anchor protein