This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Alias Symbols: TRF2, TRBF2
Protein Interaction Partner: UBC, TERF2IP, TINF2, EP300, SLX4, RPA3, RPA2, RPA1, BMI1, DCLRE1B, BLM, ATM, VCP, NBN, MRE11A, HMGA1, RAD50, TOP3A, HSP90AA1, TEP1, SF3B2, TOP2A, TFAP4, OCM2, NUMA1, NCL, NASP, HMGN2, HMGN1, HMGB1, H2AFX, XRCC6, CTBP1, ASS1, APEX1, ANXA5, DDX39A, HMGN3, D