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Human STAT5A ELISA Kit for Cell ELISA - ABIN1981843
Park, Lee, Frank, Razani, Nguyen, Parlow, Russell, Hulit, Pestell, Lisanti: Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. in Molecular biology of the cell 2002
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This is the first report of a survival disadvantage of EBV+ patients with CLL, and the first time that STAT5b (显示 STAT5B ELISA试剂盒) expression is correlated with survival. The correlation of STAT5 expression with the presence of the virus, along with our survival correlations defines a subgroup of patients with CLL that may benefit from anti-STAT (显示 STAT1 ELISA试剂盒) agents.
STAT5 signaling axis drives abnormal cell proliferation in autosomal dominant polycystic kidney disease.
O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. A mutated hyperactive gain-of-function (GOF) STAT5 without O-GlcNAcylation resulted in decreased tyrosine phosphorylation, oligomerization and transactivation potential and complete loss of oncogenic transformation capacity.
p65 (显示 GORASP1 ELISA试剂盒) activation triggered by TCR signaling could promote SNRPA (显示 SNRPA ELISA试剂盒) transcription and 3' UTR (显示 UTS2R ELISA试剂盒) shortening of STAT5B (显示 STAT5B ELISA试剂盒). Thus we propose that the alternative polyadenylation switching of STAT5B (显示 STAT5B ELISA试剂盒) induced by TCR activation is mediated by SNRPA (显示 SNRPA ELISA试剂盒).
this study shows that musculin (显示 MSC ELISA试剂盒) inhibits human T-helper 17 cell response to interleukin 2 (显示 IL2 ELISA试剂盒) by controlling STAT5B (显示 STAT5B ELISA试剂盒) activity
STAT5 interacted with minichromosome maintenance (MCM) complex, suggesting that STAT5 directly facilitates viral DNA replication by recruiting the helicase complex of the cellular DNA replication machinery to viral DNA replication centers.
Molecular interactions of EphA4 (显示 EPHA4 ELISA试剂盒), growth hormone receptor (显示 GHR ELISA试剂盒), Jak2 (显示 JAK2 ELISA试剂盒), and STAT5B (显示 STAT5B ELISA试剂盒) have been described.
High STAT5 phosphorylation is associated with systemic lupus erythematosus.
NPM1 (显示 NPM1 ELISA试剂盒) downregulation by P-STAT5 is mediated by impairing the BRCA1-BARD1 (显示 BARD1 ELISA试剂盒) ubiquitin ligase, which controls the stability of NPM1 (显示 NPM1 ELISA试剂盒). In turn, decreased NPM1 (显示 NPM1 ELISA试剂盒) levels led to suppression of p53 (显示 TP53 ELISA试剂盒) expression, resulting in enhanced cell survival.
All merkel cell carcinoma (MCC) cases with a good outcome expressed pSTAT5B, whereas all MCC cases with a poor outcome did not express pSTAT5B; hence, pSTAT5B expression may be an indicator of positive prognosis in patients with MCC.
Instead, we find that STAT5B (显示 STAT5B ELISA试剂盒) is dominant over STAT5A in CD4 (显示 CD4 ELISA试剂盒)(+) 'helper' T cells for both effector and regulatory (Treg) responses and, therefore, uniquely necessary for immunological tolerance.
Data indicate that obesity-induced insulin (显示 INS ELISA试剂盒) resistance and lipotoxicity can be treated with ginsenoside Rg3, which acts though the STAT5-PPAR gamma (显示 PPARG ELISA试剂盒) pathway in vivo and in vitro.
STAT5a regulates miR (显示 MLXIP ELISA试剂盒)-135a transcription by binding to both miR (显示 MLXIP ELISA试剂盒)-135a-1 and miR135a-2 promoter elements
These studies establish the importance of STAT5 in macrophages during ductal morphogenesis in the mammary gland and demonstrate that altering STAT5 function in macrophages can affect the development of tissue-specific disease.
findings show that Stat5 is required for CD103 (显示 ITGAE ELISA试剂盒)(+) dendritic cell and alveolar macrophage development.These findings demonstrate the critical importance of Stat5 signaling in maintaining lung homeostasis, and underscore the importance of resident macrophages in moderating tissue damage and excess inflammation.
STAT5 target genes such as Oncostatin M (显示 OSM ELISA试剂盒) were highly expressed in FLT3 (显示 FLT3 ELISA试剂盒)-ITD(+) myeloid but not in FLT3 (显示 FLT3 ELISA试剂盒)-ITD(+) lymphoid progenitor cells; lineage-specific STAT5 activation in hematopoietic progenitor cells predicts the FLT3 (显示 FLT3 ELISA试剂盒)(+)-mediated leukemic phenotype in mice.
findings reveal an essential role for STAT5 in maintaining lipid homeostasis in white adipose tissue and provide a rationale for future studies into the potential of STAT5 manipulation to improve outcomes in metabolic diseases.
deregulation of local signal transducer and activator of transcription 5 signaling augments high fat diet-induced lipid accumulation in both muscle and liver.
Data show that CUZD1 (显示 CUZD1 ELISA试剂盒) interacts with a complex containing JAK1 (显示 JAK1 ELISA试剂盒)/JAK2 (显示 JAK2 ELISA试剂盒) and STAT5, downstream transducers of prolactin (显示 PRL ELISA试剂盒) signaling in the mammary gland.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found
Results indicate that SNPs in STAT5A and JAK2 (显示 JAK2 ELISA试剂盒) genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts.
INVESTIGATION OF STAT5A, FSHR (显示 FSHR ELISA试剂盒) AND LHR (显示 LHCGR ELISA试剂盒) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells.
STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 (显示 FGF2 ELISA试剂盒) gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
Base sequence variation in STAT5A-noncoding region was studied.
The association of fertilization rate with STAT5A polymorphisms was evaluated in ocytes. Associations were found for 6 and 2 SNP. 5 SNP showed associations with both embryonic survival and fertilization rate compared with 1 SNP.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
mammary gland factor STAT5A
, mammary gland factor
, signal transducer and activator of transcription 5
, STAT5A, Mammary Gland Factor
, signal transducer and activator of transcription 5A
, signal transducer and activator of transcription 5A-like
, signal transducer and activator of transcription 5B
, signal transducer and activator of transcription 5B L homeolog