Use your antibodies-online credentials, if available.
Select your species
Human STAT4 ELISA Kit for Cell ELISA - ABIN1981841
Kaplan, Sun, Hoey, Grusby: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. in Nature 1996
Show all 11 Pubmed References
IL13 (显示 IL13 ELISA试剂盒) AA of rs20541 and STAT4 TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 (显示 IL13 ELISA试剂盒) AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 TT did not respond to high-dose ICSs.
STAT4 mRNA expression was significantly correlated with IFNG (显示 IFNG ELISA试剂盒) mRNA expression.
findings demonstrate that variants in STAT4 play a critical role in HBV infection and clearance in the Chinese Han population.
STAT4 rs7574865G/T polymorphism is associated with rheumatoid arthritis and systemic lupus erythematosus in Mexican women
Results found that activated STAT4 was overexpressed in epithelial cells of ovarian cancer and provide evidence that it promotes ovarian cancer metastasis via tumor-derived Wnt7a (显示 WNT7A ELISA试剂盒)-induced activation of cancer-associated fibroblasts.
STAT4 rs7574865 gene polymorphism is associated with the susceptibility of primary biliary cirrhosis in the Han population of Jiangsu province.
The findings results confirm the important role of STAT4 gene in the predisposition to Systemic sclerosis and its phenotypes, such as the presence of Interstitial Lung disease , cardiac injury , and seropositivity for anti-topoisomerase I (显示 TOP1 ELISA试剂盒) antibodies in the Russian population.
results show specific and dominant contribution of STAT4 in the hematopoietic compartment to metabolic health and inflammation in diet-induced obesity.
reported that SNPs in STAT4, PTPN2 (显示 PTPN2 ELISA试剂盒), PSORS1C1, and TRAF3IP2 (显示 TRAF3IP2 ELISA试剂盒) are associated with response to TNF (显示 TNF ELISA试剂盒)-i treatment in RA patients; however, these findings should be validated in a larger population
This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-alpha (显示 IFNA ELISA试剂盒)/beta signaling and highlights the unique activity of this cytokine to acutely block the expression of an inflammatory cytokine in human T cells.
The results show that STAT4 plays a critical role in mediating both Th1 (显示 HAND1 ELISA试剂盒) and Th2 responses upon immunization with monophosphoryl lipid A.
this study shows that STAT4 regulates the CD8 (显示 CD8A ELISA试剂盒)(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin (显示 INS ELISA试剂盒)-resistant Ldlr (显示 LDLR ELISA试剂盒)(-/-) mice
virus-specific effector and memory CD4 (显示 CD4 ELISA试剂盒) T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 (显示 CD4 ELISA试剂盒) T cells was apparent in mice lacking both transcription factors.
STAT4 has a pro-atherogenic role that is at least partially independent of Th1 (显示 HAND1 ELISA试剂盒) cell-derived interferon-gamma (显示 IFNG ELISA试剂盒)
Modulation of IL-12 (显示 IL12A ELISA试剂盒)/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes
This study found that stathmin (显示 STMN1 ELISA试剂盒) plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin (显示 STMN1 ELISA试剂盒) mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory
STAT4 controls GM-CSF (显示 CSF2 ELISA试剂盒) production by both Th1 (显示 HAND1 ELISA试剂盒) and Th17 cells during experimental autoimmune encephalomyelitis.
Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri (显示 POSTN ELISA试剂盒)-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation.
T-bet- and STAT4-dependent IL-33 (显示 IL33 ELISA试剂盒) receptor expression have roles in directly promoting antiviral Th1 (显示 HAND1 ELISA试剂盒) cell responses
Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma (显示 IFNG ELISA试剂盒) and CD25 (显示 IL2RA ELISA试剂盒) induction through STAT4-independent pathways.
These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
signal transducer and activator of transcription 4