Use your antibodies-online credentials, if available.
Select your species
Human STAT3 ELISA Kit for Cell ELISA - ABIN1981839
Kanai, Konda, Nakajima, Izumi, Kanda, Nanakin, Kubohara, Chiba: Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. in Oncogene 2003
Show all 3 Pubmed References
Human STAT3 ELISA Kit for Sandwich ELISA - ABIN625232
Sharma, Yang, Xi, Grotta, Aronowski, Savitz: IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. in Brain research 2011
Show all 2 Pubmed References
Human STAT3 ELISA Kit for Sandwich ELISA - ABIN625245
Tukaj, Grüner, Tukaj, Zillikens, Kasperkiewicz: Calcitriol exerts anti-inflammatory effects in keratinocytes treated with autoantibodies from a patient with bullous pemphigoid. in Journal of the European Academy of Dermatology and Venereology : JEADV 2015
ginsenoside Rb2 (显示 RBL2 ELISA试剂盒) inhibits osteoclast differentiation by blocking NF-kappaB (显示 NFKB1 ELISA试剂盒) and STAT3 signaling pathways.
The activation of STAT3 was much higher in Gal12 (显示 LGALS12 ELISA试剂盒)(-/-) macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10 (显示 IL10 ELISA试剂盒). Adipocytes showed higher insulin (显示 INS ELISA试剂盒) sensitivity when treated with Gal12 (显示 LGALS12 ELISA试剂盒)(-/-) macrophage-conditioned media than those treated with Gal12 (显示 LGALS12 ELISA试剂盒)(+/+) macrophages.
After Dox treatment, the protein expression of p-Jak2 (显示 JAK2 ELISA试剂盒) and p-Stat3 levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2 (显示 JAK2 ELISA试剂盒)/STAT3 pathway was partially involved in MT protection against Dox-induced cardiotoxicity
Studied effect of Coptis Chinensis on glioma cells; results showed Coptis Chinensis induced cell cycle arrest and apoptosis in glioma cells, down-regulated the signal transducer and activator oftranscription 3 (STAT3) phosphorylation levels, and reduced the expression of histone deacetylase 3 (HDAC3 (显示 HDAC3 ELISA试剂盒)).
M1 macrophages with inhibited STAT3, STAT6 (显示 STAT6 ELISA试剂盒) and/or SMAD3 (显示 SMAD3 ELISA试剂盒) effectively restrict tumor growth. The findings justify the development of new anti-tumor cell therapy technology.
Our data suggest that the inhibition of sRAGE on I/R-induced apoptosis is associated with activation and expression of proteasome, including improved proteasome activity and elevated beta1i (显示 PSMB9 ELISA试剂盒) and beta5i expression mediated by STAT3 activation. We predict that sRAGE is a novel intervention to target UPS activation for preventing and treating myocardial apoptosis.
our data indicate that luteolin diminishes the proinflammatory mediators NO, inflammatory cytokines and the expression of their regulatory genes, iNOS (显示 NOS2 ELISA试剂盒) and COX-2 (显示 COX2 ELISA试剂盒), in PRV-infected RAW264.7 cells by inhibiting STAT1 (显示 STAT1 ELISA试剂盒)/3 dependent NF-kappaB (显示 NFKB1 ELISA试剂盒) activation and inducing Nrf2mediated HO-1 (显示 HMOX1 ELISA试剂盒) expression.
activation of beta2-AR accelerated hepatocyte proliferation and improved recellularized liver function by mediating the IL-6 (显示 IL6 ELISA试剂盒)/Stat 3 signalling pathway, indicating that nervous system regulation may be an essential component contributing to the complexity of recellularized liver in tissue engineering
Stat3 mediates the expression of iNOS (显示 NOS2 ELISA试剂盒) to promote IFNgamma/TNFalpha (显示 TNF ELISA试剂盒)-induced muscle atrophy.
BMI1 (显示 BMI1 ELISA试剂盒) and MEL18 (显示 PCGF2 ELISA试剂盒) contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells.
G-rich sequences in the STAT3 gene could form G-quadruplexes under near physiological conditions.
nuclear localization of pSTAT3 in leukemic cells may have a role in hematopoietic stem cell transplant-associated large granular lymphocytic leukemia
CD36 (显示 CD36 ELISA试剂盒)/STAT3 SNPs linked to cardiovascular disease may modulate the effects of different diets on biochemical and inflammatory markers among these subjects.
Acquired lapatinib-resistant HER2 (显示 ERBB2 ELISA试剂盒)-positive breast cancer cells had elevated IL-6 (显示 IL6 ELISA试剂盒), and that elevated IL-6 (显示 IL6 ELISA试剂盒) maintained the stemness population and property within these resistant cells through the activation of STAT3.
STAT3/STAT1 (显示 STAT1 ELISA试剂盒) ratios are better clinical predictors in Colorectal carcinoma as compared to STAT3 or STAT1 (显示 STAT1 ELISA试剂盒) levels alone.
Multilayer OMIC data analysis uncovered methylation hallmarks in genetically defined Medullary thyroid carcinoma (MTC (显示 MT1A ELISA试剂盒)) and revealed JAK (显示 JAK3 ELISA试剂盒)/Stat (显示 STAT1 ELISA试剂盒) signaling effector STAT3 as a potential therapeutic target for the treatment of RET (显示 RET ELISA试剂盒)(M918T) MTCs
Suggest a positive feedback mechanism via the STAT1 (显示 STAT1 ELISA试剂盒)/3 pathway sustains cytokine production and reveal a reciprocal regulatory role of JAK (显示 JAK3 ELISA试剂盒)/STAT (显示 STAT1 ELISA试剂盒) in TNFalpha (显示 TNF ELISA试剂盒)-mediated senescence.
the EGFR (显示 EGFR ELISA试剂盒)/STAT3 pathway contributed to CDDP-induced CEBPD (显示 CEBPD ELISA试剂盒) expression in UCUB cells. Gefitinib and S3I-201 treatment significantly reduced the expression of CEBPD (显示 CEBPD ELISA试剂盒) and enhanced the sensitivity of CDDP-resistant UCUB cells to CDDP and paclitaxel
Primary open angle glaucoma in type 2 diabetes: Implications of the IL-10 (显示 IL10 ELISA试剂盒)/STAT3-mediated anti-inflammatory response
Our study supports the development of strategies targeting STAT3 inhibition in combination with conventional chemotherapy for patients with high-risk neuroblastoma (显示 ARHGEF16 ELISA试剂盒)
STA3 (显示 ARHGEF3 ELISA试剂盒) facilitates TLR4 (显示 TLR4 ELISA试剂盒)-dependent IL-6 (显示 IL6 ELISA试剂盒) and IL-8 (显示 IL8 ELISA试剂盒) production via IL-6 (显示 IL6 ELISA试剂盒) receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (显示 IL6 ELISA试剂盒) (IL), in the presence of its soluble receptor (显示 IFNAR1 ELISA试剂盒) (sIL (显示 STIL ELISA试剂盒)-6R), induces activation of JAK1 (显示 JAK1 ELISA试剂盒), JAK2 (显示 JAK2 ELISA试剂盒), and STAT1 (显示 STAT1 ELISA试剂盒)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (显示 VEGFA ELISA试剂盒) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (显示 NOX1 ELISA试剂盒)-mediated activation of STAT3.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (显示 CCND2 ELISA试剂盒) and PSEN1 (显示 PSEN1 ELISA试剂盒) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (显示 LIF ELISA试剂盒) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (显示 FTH1 ELISA试剂盒)-supplemented media.
Data suggest that IL-6 (interleukin 6 (显示 IL6 ELISA试剂盒)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (显示 IL6 ELISA试剂盒)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (显示 JAK1 ELISA试剂盒) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (显示 MMP2 ELISA试剂盒) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (显示 CDC25A ELISA试剂盒) expression during oogenesis. Accordingly, restoring Cdc25a (显示 CDC25A ELISA试剂盒) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (显示 PTPN9 ELISA试剂盒) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (显示 GATA1 ELISA试剂盒) and ZBP-89 (显示 ZNF148 ELISA试剂盒).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (显示 SOCS3 ELISA试剂盒) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (显示 RAB1A ELISA试剂盒) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (显示 PRCP ELISA试剂盒) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3