anti-STAT1 (STAT1) 抗体产品概述

Full name:
anti-Signal Transducer and Activator of Transcription 1, 91kDa 抗体 (STAT1)
在www.antibodies-online.cn可供635 Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) 抗体的38不同的供货商。 再加上,我们可以发STAT1 试剂盒 (46)STAT1 蛋白 (21)和数多这个蛋白质的别的产品。 总共747 STAT1产品已列进来了。
别名:
2010005J02Rik, AA408197, CANDF7, DD6G4-4, dZ182H3.3, H2RSP, IMUP, IMUP-1, IMUP-2, ISGF-3, si:by51f19.1, si:by134g18.2, si:dz73o4.2, si:dz182h3.3, si:dz199m19.1, STAT, STAT1, STAT4, STAT91, XStat1
列出全部抗体 基因 基因ID UniProt
STAT1 72275  
STAT1 25124  
STAT1 6772 P42224

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引用最多的anti-STAT1 抗体

  1. Human Polyclonal STAT1 Primary Antibody for EIA, IHC (p) - ABIN358231 : Garcin, Marq, Iseni, Martin, Kolakofsky: A short peptide at the amino terminus of the Sendai virus C protein acts as an independent element that induces STAT1 instability. in Journal of virology 2004 (PubMed)
    Show all 5 references for 358231

  2. Human Polyclonal STAT1 Primary Antibody for IF (p), IHC (p) - ABIN674889 : Wang, Wang, Song, Chu, Qu: Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015 (PubMed)
    Show all 3 references for 674889

  3. Human Monoclonal STAT1 Primary Antibody for IHC (p), IP - ABIN269146 : Kovarik, Boudny, Kocak, Lauerova, Fait, Vagundova: Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation. in International journal of molecular medicine 2003 (PubMed)
    Show all 2 references for 269146

  4. Cow (Bovine) Polyclonal STAT1 Primary Antibody for IHC, WB - ABIN2780843 : Battle, Lynch, Frank: Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. in Cancer research 2006 (PubMed)
    Show all 2 references for 2780843

  5. Human Polyclonal STAT1 Primary Antibody for IF, IHC - ABIN1533008 : Durbin, Hackenmiller, Simon, Levy: Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. in Cell 1996 (PubMed)
    Show all 2 references for 1533008

  6. Human Polyclonal STAT1 Primary Antibody for ELISA, WB - ABIN1533729 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)

更多抗STAT1的相互作用对抗体

Mouse (Murine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. In cultured macrophages, LPS (显示 TLR4 抗体)-induced expression of monocyte chemoattractant protein (MCP)-1 (显示 CPT1B 抗体) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (显示 NFKBIZ 抗体) activities.

  2. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (显示 MAPK14 抗体), AAT (显示 SERPINA1A 抗体), signal transducer and activator of transcription 1 (STAT1) and activating transcription factor2 (ATF2 (显示 ATF2 抗体))

  3. This secreted effector, toxoplasma inhibitor of STAT1-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2 (显示 CHD4 抗体)/NuRD to STAT1-dependent promoters, resulting in altered chromatin and blocked transcription.

  4. Microbiome depletion as a result of broad-spectrum antibiotic treatment disrupts basal Stat1 signaling and alters T-cell homeostasis, leading to impaired progenitor maintenance and granulocyte maturation.

  5. We revealed that in mouse mesenchymal stem cells IFN-gamma-induced (显示 SAMHD1 抗体) immunoregulation is mediated by early phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT3 (显示 STAT3 抗体), which is significantly enhanced by an extracellular signal-regulated kinase 1/2 (显示 MAPK3 抗体)-dependent mTOR (显示 FRAP1 抗体) inhibition, thereby promoting pSTAT1 nuclear translocation.

  6. these results define a differential regulation of TLR-mediated activation and differentiation of MZ B cells by STAT1 and reveal a STAT1-dependent, but IFN-independent, antibody response during infection and inflammation.

  7. B cell-intrinsic IFN-gamma (显示 IFNG 抗体) receptor (IFN-gammaR (显示 IFNGR1 抗体)) and STAT1 signaling are required for Spontaneously developed germinal centers and follicular T helper cell (Tfh cell) development.

  8. Inhibitor-sensitive tyrosine kinase (显示 TYRO3 抗体) controls the population heterogeneity of basal STAT1 activity in Ube1l (显示 UBA7 抗体) deficient fibroblasts.

  9. The studies presented here reveal that the ability of IFN-gamma (显示 IFNG 抗体) to inhibit parasite replication in astrocytes in vitro is dependent on signal transducer and activator of transcription 1 (STAT1) and that mice that specifically lack STAT1 in astrocytes are unable to limit parasite replication in the central nervous system (CNS).

  10. We found that STAT-1(-/-) MRL lpr (显示 FAS 抗体) mice, but not IRF-9 (显示 IRF9 抗体)(-/-) or IFNAR-2 (显示 IFNAR2 抗体)(-/-) mice, developed interstitial nephritis characterized by infiltration with RORgammat-positive lymphocytes, macrophages, and eosinophils. Despite pronounced interstitial kidney disease and abnormal kidney function, STAT-1(-/-) mice had decreased proteinuria, glomerulonephritis, and autoantibody production.

Human Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. MFSD2B, CCL20 (显示 CCL20 抗体) and STAT1, or STARD7 (显示 STARD7 抗体) and ZNF512 (显示 ZNF512 抗体) genes may be risk or protect factors in prognosis of ADC (显示 ADC 抗体); HTR2B (显示 HTR2B 抗体), DPP4 (显示 DPP4 抗体), and TGFBRAP1 (显示 TGFBRAP1 抗体) genes may be risk factors in prognosis of SQC (显示 QPCT 抗体).

  2. In cultured macrophages, LPS (显示 IRF6 抗体)-induced expression of monocyte chemoattractant protein (MCP)-1 (显示 CCL2 抗体) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (显示 NFKBIZ 抗体) activities.

  3. Functional analysis of NK cells shows a significant impairment of cytolytic and degranulation activities in chronic mucocutaneous candidiasis patients with STAT1 GOF mutations

  4. Mechanistic investigations reveal that AJUBA (显示 AJUBA 抗体) specifically binds the FERM domain of JAK1 (显示 JAK1 抗体) to dissociate JAK1 (显示 JAK1 抗体) from the IFNgamma recepter, resulting in an inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA (显示 AJUBA 抗体) in CRC (显示 CALR 抗体) specimens is negatively correlated with the levels of IFIT2 (显示 IFIT2 抗体) and pSTAT1

  5. Low STAT1 expression is associated with Pancreatic cancer.

  6. STAT1 and IRF1 (显示 IRF1 抗体) collaborate to induce interferon-gamma (显示 IFNG 抗体) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 and IRF1 (显示 IRF1 抗体) at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.

  7. IFITM1 (显示 IFITM1 抗体) suppression blocks proliferation and invasion of aromatase (显示 CYP19A1 抗体) inhibitor-resistant breast cancer in vivo by JAK (显示 JAK3 抗体)/STAT1-mediated induction of p21 (显示 CDKN1A 抗体).

  8. This study reports a new role for SETD2 (显示 SETD2 抗体) in promoting IFNalpha-induced antiviral immune response by directly methylating STAT1 on lysine 525 and catalyzing H3K36me3 on the promoters of some IFN-stimulated genes (ISGs such as ISG15 (显示 ISG15 抗体)) to activate gene transcription. Thus, SETD2 (显示 SETD2 抗体) enhances host antiviral immunity by strengthening IFNalpha signaling both post-translationally and epigenetically.

  9. STAT1 gain-of-function mutations underlie Autosomal dominant chronic mucocutaneous candidiasis, as well as an unexpectedly wide range of other clinical features, including not only a variety of infectious and autoimmune diseases, but also cerebral aneurysms and carcinomas that confer a poor prognosis.

  10. Six different heterozygous mutations in STAT1 were detected in the seven patients (Patients 3 and 4 shared identical mutations). Three of these mutations were recurrent variants (p.R274Q, p.K388E and p.P329L), whereas the other three (p.N357D, p.M202T, and p.T437I), involving both the coiled coil domain (CCD (显示 RUNX2 抗体)) and DNA binding domain (DBD), have not been reported previously.

Pig (Porcine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (显示 IFNA 抗体) response by inducing STAT1 degradation.

  2. this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets

  3. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (显示 JAK3 抗体)-STAT1) signaling pathway.

  4. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (显示 STAT2 抗体) nuclear translocation.

  5. Nsp1beta inhibits interferon-activated (显示 MNDA 抗体) STAT1/STAT2 (显示 STAT2 抗体) signal transduction by inducing karyopherin-alpha1 degradation.

  6. STAT1 is involved in mediating the action of ghrelin (显示 GHRL 抗体) on ovarian cell functions.

  7. the majority of the STAT1/STAT2 (显示 STAT2 抗体)/IRF9 (显示 IRF9 抗体) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

  8. Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.

  9. Nitric oxide-dependent increase in caspase-8 (显示 CASP8 抗体) mRNA levels is associated with phosphorylation of STAT-1 at Ser (显示 SIGLEC1 抗体)-727 and STAT1 binding to the caspase-8 (显示 CASP8 抗体) promoter in cultured lung endothelial cells.

  10. Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.

Cow (Bovine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Report interferon-tau dependent STAT1 regulation of SOCS (显示 CISH 抗体) genes in bovine endometrium during estrus cycle and embryo implantation.

  2. the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate

  3. results show for the first time that interleukin-6 (显示 IL6 抗体) (IL), in the presence of its soluble receptor (显示 IFNAR1 抗体) (sIL (显示 STIL 抗体)-6R), induces activation of JAK1 (显示 JAK1 抗体), JAK2 (显示 JAK2 抗体), and STAT1/STAT3 (显示 STAT3 抗体) proteins in bovine articular chondrocytes

  4. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (显示 CSN2 抗体) synthesis and fat metabolism.

  5. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (显示 STAT2 抗体).

STAT1 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT1

  • signal transducer and activator of transcription 1, 91kDa (STAT1) 抗体
  • RIKEN cDNA 2200002D01 gene (2200002D01Rik) 抗体
  • signal transducer and activator of transcription 1 (Stat1) 抗体
  • signal transducer and activator of transcription 1, 91kDa (stat1) 抗体
  • signal transducer and activator of transcription 4 (stat4) 抗体
  • 2010005J02Rik 抗体
  • AA408197 抗体
  • CANDF7 抗体
  • DD6G4-4 抗体
  • dZ182H3.3 抗体
  • H2RSP 抗体
  • IMUP 抗体
  • IMUP-1 抗体
  • IMUP-2 抗体
  • ISGF-3 抗体
  • si:by51f19.1 抗体
  • si:by134g18.2 抗体
  • si:dz73o4.2 抗体
  • si:dz182h3.3 抗体
  • si:dz199m19.1 抗体
  • STAT 抗体
  • STAT1 抗体
  • STAT4 抗体
  • STAT91 抗体
  • XStat1 抗体

Protein level used designations for STAT1

signal transducer and activator of transcription 1-alpha/beta , HAI-2 related small protein , signal transducer and activator of transcription-1 , transcription factor ISGF-3 components p91/p84 , signal transducer and activator of transcription 4 , signal transducer and activator of transcription 1 , transcription factor ISGF-3 , activator of transcription , signal transduction

GENE ID SPECIES
100307049 Ovis aries
72275 Mus musculus
20846 Mus musculus
25124 Rattus norvegicus
6772 Homo sapiens
424044 Gallus gallus
488449 Canis lupus familiaris
396655 Sus scrofa
510814 Bos taurus
398324 Xenopus laevis
100343893 Oryctolagus cuniculus
368519 Danio rerio
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