anti-人 PTPN6 抗体 for Immunofluorescence

Recommended PTPN6 Antibody (supplied by: Log in to see )

抗原
Protein-tyrosine Phosphatase 1C (PTPN6) 抗体
  • SHP
  • SHP-1
  • Shp1
  • HCP
  • HCPH
  • HPTP1C
  • PTP-1C
  • SH-PTP1
  • SHP-1L
  • SHP1
  • Hcph
  • Ptp1C
  • hcp
  • me
  • motheaten
  • Ptph6
  • Shp-1
  • DRPLA
  • protein tyrosine phosphatase, non-receptor type 6
  • nuclear receptor subfamily 0, group B, member 2
  • PTPN6
  • Nr0b2
  • Ptpn6
抗原表位
AA 492-597
26
24
15
10
8
6
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
适用
犬, 人, 小鼠, 大鼠
204
90
85
6
3
2
2
2
1
1
1
1
1
宿主
小鼠
133
39
33
克隆类型
单克隆
标记
This PTPN6 antibody is un-conjugated
8
8
7
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
应用范围
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
148
84
58
35
35
29
17
10
8
6
5
4
2
1
选项
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产品编号 ABIN967766
产品在该地区无法提供。
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.14905 ABIN967767 IF IP IHC WB Mouse IgG1 AA 492-597 Log in to see 52-PTP1C-SHP1 5
12.14905 ABIN1882123 IF IHC (p) WB Rabbit AA 247-277, Center Log in to see Polyclonal 2
12.14905 ABIN4348608 ICC IF IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 1
12.14905 ABIN1870549 IF IHC Rabbit IgG pTyr536 Log in to see Polyclonal
12.14905 ABIN1874455 IF IHC WB Rabbit IgG Log in to see Polyclonal
12.14905 ABIN2404230 IF IHC WB Rabbit IgG Log in to see Polyclonal
12.14905 ABIN3020460 IF IHC Rabbit pTyr536 Log in to see Polyclonal
1 ABIN197592 IF IHC (p) WB Rabbit Tyr536 Log in to see Polyclonal 4
1 ABIN319255 IF IHC (p) Rabbit pTyr536 Log in to see Polyclonal 4
1 ABIN363036 IF IHC WB Rabbit IgG AA 534-538 Log in to see Polyclonal 2
1 ABIN362408 IF IHC Rabbit IgG pTyr536 Log in to see Polyclonal 4
1 ABIN114550 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY6
1 ABIN114551 EIA IHC (fro) IF WB Mouse IgG2a Log in to see PTY10
1 ABIN2882770 IF IHC Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN1842510 IF IHC WB Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN452174 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY11
1 ABIN452175 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY15
1 ABIN5531900 IF IHC (p) WB Rabbit Ig Fraction AA 247-277 Log in to see Polyclonal
1 ABIN2888224 IF IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN1959784 IF IHC (p) Rabbit pTyr536 Log in to see Polyclonal

General

抗原 Protein-tyrosine Phosphatase 1C (PTPN6) 抗体
抗原表位 AA 492-597
(26), (24), (15), (10), (8), (6), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 犬, 人, 小鼠, 大鼠
(204), (90), (85), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1)
宿主 小鼠
(133), (39), (33)
克隆类型 (克隆位点)
单克隆   ( )
标记 This PTPN6 antibody is un-conjugated
(8), (8), (7), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
应用范围 Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(148), (84), (58), (35), (35), (29), (17), (10), (8), (6), (5), (4), (2), (1)
Pubmed 5个引用可参考
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PTPN6抗体详情

PTPN6目标详情 使用细节 贮存及处理 References for anti-PTPN6 antibody (ABIN967766) 图像
交叉反应 犬, 大鼠, 小鼠
产品特性 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
免疫原 Human PTP1C aa.. 492-597
克隆位点 52-PTP1C-SHP1
亚型 IgG1

PTPN6目标详情

PTPN6抗体详情 使用细节 贮存及处理 References for anti-PTPN6 antibody (ABIN967766) 图像 回页首
抗原
别名 PTP1C (PTPN6 Antibody 摘要)
背景 PTP1C (SH-PTP1, SHP-1, or HCP) is a protein-tyrosine phosphatase (PTP) that is expressed in epithelial and hematopoietic cells. It contains two N-terminal SH2 domains and a C-terminal phosphatase domain. While its distribution is primarily cytosolic, exposure to various stimuli induces movement of PTP1C to other cellular locations to allow interaction with its substrates. This enzyme associates with the IL-3, IL-4, erythropoietin, and stem cell factor receptors and may regulate their signaling pathways by dephosphorylation of their receptors or their downstream effectors. Motheaten mice, which possess a nonfunctional PTP1C gene, display multiple hematopoietic abnormalities including increased proliferation and activation of myeloid cells. Studies involving these mice have clearly implicated PTP1C in negative regulation of CSF-1 (colony stimulating factor-1) mitogenic signaling and have demonstrated a role for PTP1C as an intermediate between Ras and the MAP kinase pathway.
分子量 68 kDa
途径 JAK/STAT Signaling, TCR Signaling, TLR signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2

使用细节

PTPN6抗体详情 PTPN6目标详情 贮存及处理 References for anti-PTPN6 antibody (ABIN967766) 图像 回页首
说明

Related Products: ABIN968537, ABIN967389

限制 仅限研究用

贮存及处理

PTPN6抗体详情 PTPN6目标详情 使用细节 References for anti-PTPN6 antibody (ABIN967766) 图像 回页首
状态 Liquid
浓度 250 μg/mL
缓冲液 Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store undiluted at -20° C.

References for anti-PTPN6 antibody (ABIN967766)

PTPN6抗体详情 PTPN6目标详情 使用细节 贮存及处理 图像 回页首
有引用在:

Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, 2002

Keilhack, Müller, Böhmer, Frank, Weidner, Birchmeier, Ligensa, Berndt, Kosmehl, Günther, Müller, Birchmeier, Böhmer: "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1." in: The Journal of cell biology, Vol. 152, Issue 2, pp. 325-34, 2001

Lund-Johansen, Davis, Bishop, de Waal Malefyt: "Flow cytometric analysis of immunoprecipitates: high-throughput analysis of protein phosphorylation and protein-protein interactions." in: Cytometry, Vol. 39, Issue 4, pp. 250-9, 2000

Liu, Hill, Chernoff: "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)." in: The Journal of biological chemistry, Vol. 271, Issue 49, pp. 31290-5, 1997

Kenner, Anyanwu, Olefsky, Kusari: "Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling." in: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 19810-6, 1996

图像

PTPN6抗体详情 PTPN6目标详情 使用细节 贮存及处理 References for anti-PTPN6 antibody (ABIN967766) 回页首
厂商提供的图像
Western Blotting (WB) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody (ABIN967766) Western blot analysis of PTP1C on Jurkat cell lysate. Lane 1: 1:500, lane 2: 1:1000, ...
Immunofluorescence (IF) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody (ABIN967766) Immunofluorescent staining on HL60 cells.